Dose-Response Relationships to Pancreozymin in Normal Subjects and Patients with Chronic Pancreatitis

Hormone-elicited enzyme release by the small intestinal wall

“…The dose range in which the enzyme release occurs appears to be well within the range reported to elicit pancreatic enzyme secretion in dogs and man on a per kg body weight basis (Hanscom and Littman, 1963;Preshaw, Adashek, Cooke, and Grossman, 1965). The CCK-PZ-elicited release of enzymes was further increased by the effect of bile in the intestinal lumen; this increase was observed both when the common bile duct was patent (Table I, Fig.…”

Secretory response of the human pancreas to continuous intravenous infusion of pancreozymin-cholecystokinin (Cecekin).

“…(5-1 to laneous disease is shown in Figure 3 3-9 4-5 5-2 5-8 6 11 163 212 198 205 76 327 315 321 323 428 392 410 6 274 330 318 324 351 426 333 379 489 414 368 391 522 386 288 337 8 88 163 168 165 164 68 96 82 139 108 108 108 176 110 110 110 1 2 2 2 17 62 70 66 130 203 219 211 249 238 230 234 293 257 239 248 243 262 286 274 8 342 138 109 123 119 58 51 54 287 335 514 424 361 207 376 291 15 12 13 257 263 284 273 280 261 281 271 275 264 258 261 14 198 279 208 251 281 260 214 237 280 295 264 279 220 270 252 261 8 16 84 126 105 149 255 245 250 336 395 221 4-0 2-6 14-4 13-9 14.1 10-3 5-2 8-2 6-7 11*2 10-1 9-6 9-8 16-9 10-7 10-1 10-4 0-8 0-6 0-4 0.5 6-6 40-1 19-5 29-8 19-3 17-2 14-6 15-8 16-3 14-0 13-3 13-6 16-2 12-5 1 1.5 12-0 11-5 11-3 11-1 11-2 6-2 25-6 10-2 11-2 10-7 17-2 7-9 6-4 7-1 29-3 27-7 34-5 31-2 24-7 12-7 28-4 20-5 3.7 3.4 3.5 14-0 14-0 13-8 13-9 15-2 12-5 14-4 13-4 15-4 14-5 13-8 14-1 found between the activity of the enzymes of bovine pancreatic fluid obtained by pancreatic duct cannulation and the protein content of the pancreatic fluid (Keller, Cohen, and Neurath, 1958). It has been suggested by Hanscom and Littman (1963) that a similar relationship between enzyme and protein concentration may apply to human duodenal fluid. There is also evidence that the various pancreatic enzymes are produced at any given time in a constant proportion to one another (Grossman, Greengard, and Ivy, 1943).…”

Validity of polyethyleneglycol in the study of the total pancreatic secretion in man after stimulation by secretin, pancreozymin, or food.

“…The decreasing values for the integrated endogenous intestinal flow and, to a minor degree of amylase secretion, in the later periods following pancreozymin are in fair accord wtih the short time of action of injected pancreozymin (Werner and Mutt, 1954;Dreiling and Janowitz, 1962;Hanscom and Littman, 1963).…”