Validity of polyethyleneglycol in the study of the total pancreatic secretion in man after stimulation by secretin, pancreozymin, or food.

Pancreatic enzymes in human duodenal juice--a comparison of responses in secretin pancreozymin and Lundh Borgstrom tests.

“…1), the delayed volume response to secretin in the quantitative study (Table 3, Fig. 5), as previously encountered by Worning (1967), must be considered to be anomalous. Both pure secretin and Boots secretin have been shown to inhibit duodenal motility (Dinoso et al, 1966;Chey et al, 1967;Osnes, 1975) and it is likely that this effect, like the effect on flow rate of pancreatic juice, is greatest soon after intravenous injection.…”

“…In addition, low lipase and amylase concentrations in two subjects with active duodenal ulceration (Table 2) were probably related to irreversible inactivation of these enzymes by unusually low duodenal pH, while trypsin, which is more stable, remained unaffected. The use of nonabsorbable markers to measure pancreatic enzyme secretion fell into disrepute after Worning's experimental (Worning and Amdrup, 1965) and clinical (Worning, 1967) studies from which he concluded that uneven mixing of marker in intestinal contents leads to over-estimation of intestinal volume-an interpretation that has been criticised by Jacobson (1966) and Fordtran (1966). Uniform mixing of marker and secretions is indeed an essential prerequisite-thus the powerful stimulant effect of CCK.PZ on duodenal peristalsis (Dahlgren, 1966; should ensure that marker dilution truly reflects secretory events after intravenous pancreozymin and endogenous CCK.PZ released by the meal.…”