Dose-response relationship for chromosome aberrations induced by X-rays or 50 MeV protons in human peripheral lymphocytes

Todorov, S.; Grigor'ev, Yu.G.; Rizhov, N. I.; Ivanov, B.; Malyutina, T. S.; Mileva, M.

doi:10.1016/0027-5107(72)90035-8

Cited by 13 publications

(4 citation statements)

References 14 publications

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“…The RBE values obtained range between ~1.0 and ~1.2 for doses up to ~5 Gy. Significantly higher RBE values were reported in studies using low energy protons (Schmid et al 1997, Mognato et al 2003 while others reported RBE values below 1.0 for lower LET values (Todorov et al 1972). For inter-chromosome exchanges in human fibroblasts the RBE was reported as <1.0 as well (0.4 keV μm −1 protons relative to 137 Cs) (Wu et al 1997).…”

Section: Chromosome Aberrationsmentioning

confidence: 82%

“…Data on chromosome aberrations include chromosome aberrations in root tips (Larsson and Kihlman 1960) and chromosome aberrations in human peripheral blood lymphocytes (Todorov et al 1972, Takatsuji et al 1983, Edwards et al 1985, Matsubara et al 1990, Rimpl et al 1990, Schmid et al 1997, Wu et al 1997, Mognato et al 2003, Govorun et al 2006. Higher aberration frequencies were reported for protons.…”

Section: Chromosome Aberrationsmentioning

confidence: 99%

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Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

2014

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Proton therapy treatments are based on a proton RBE (relative biological effectiveness) relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within tumors and normal tissues disregards the evidence that proton RBE varies with linear energy transfer (LET), physiological and biological factors, and clinical endpoint. Based on the available experimental data from published literature, this review analyzes relationships of RBE with dose, biological endpoint and physical properties of proton beams. The review distinguishes between endpoints relevant for tumor control probability and those potentially relevant for normal tissue complication. Numerous endpoints and experiments on sub-cellular damage and repair effects are discussed. Despite the large amount of data, considerable uncertainties in proton RBE values remain. As an average RBE for cell survival in the center of a typical spread-out Bragg peak (SOBP), the data support a value of ~1.15 at 2 Gy/fraction. The proton RBE increases with increasing LETd and thus with depth in an SOBP from ~1.1 in the entrance region, to ~1.15 in the center, ~1.35 at the distal edge and ~1.7 in the distal fall-off (when averaged over all cell lines, which may not be clinically representative). For small modulation widths the values could be increased. Furthermore, there is a trend of an increase in RBE as (α/β)x decreases. In most cases the RBE also increases with decreasing dose, specifically for systems with low (α/β)x. Data on RBE for endpoints other than clonogenic cell survival are too diverse to allow general statements other than that the RBE is, on average, in line with a value of ~1.1. This review can serve as a source for defining input parameters for applying or refining biophysical models and to identify endpoints where additional radiobiological data are needed in order to reduce the uncertainties to clinically acceptable levels.

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Section: Chromosome Aberrationsmentioning

confidence: 82%

Section: Chromosome Aberrationsmentioning

confidence: 99%

Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

2014

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“…Comparison with the microdosimetric data on the same beams are reported in [5]. The data were compared with those reported in literature for human lymphocytes of peripheral blood irradiated with 50 and 7.5 MeV protons [7,24]. Good agreement was found with the data at 50 MeV for chromosome breaks as far as frequency values and their dependence on the dose: indeed the dose-response curve is described by a linear function with a K value of about 0.15 (Gy) -1.…”

Section: Dose-effect Curvesmentioning

confidence: 99%

“…To this end, a series of experiments have been conducted at the cyclotron at Milan University using proton beams in the L.E.T. interval between 1 and 10 KeV/gm of tissue where the data at present available are very limited [7,8,15,24,25]. Data on the survival effect [3], the micronuclei and polynuclei formations [4] in cultured human cells and microdosimetric analysis [6] have been already reported.…”

Section: Introductionmentioning

confidence: 98%

Chromosome aberrations induced by protons up to 31 MeV in cultured human cells

Bettega

Dubini

Conti

et al. 1981

Radiat Environ Biophys

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Chromosome aberrations were induced in cultured human cells by proton beams of 31, 12, and 8 MeV. The frequencies of isochromatid breaks and dicentrics have been analysed as a function of proton energy and dose. Both effects are largely dependent on proton energy; isochromatid breaks increased linearly with the dose, whereas dicentrics show a definite parabolic behaviour. The experimental data were fitted to the analytic form Y = KDn and Y = alpha D + beta D2 and the best fitted values of the parameters are reported and discussed. The values of RBE for the isochromatid breaks are in the ratio 1.7:1.3:1 for 8, 12, and 31 MeV respectively. In the case of the dicentrics the RBE values are dose-dependent function of the type CD-n. The three distributions of dicentrics among the cells do not fit a Poisson distribution.

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Biomedical and behavioral issues

Seedhouse¹

2009

Martian Outpost

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Dose-response relationship for chromosome aberrations induced by X-rays or 50 MeV protons in human peripheral lymphocytes

Cited by 13 publications

References 14 publications

Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

Chromosome aberrations induced by protons up to 31 MeV in cultured human cells

Biomedical and behavioral issues

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