Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan

Tseng, Chin‐Hsiao; Chong, Choon-Khim; Chen, Chien-Jen; Tai, Tong-Yuan

doi:10.1016/0021-9150(95)05693-9

Cited by 162 publications

(85 citation statements)

References 21 publications

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“…The finding of a strikingly increased prevalence of macrovascular diseases observed in the arseniasis-endemic area compared with the nonendemic area is consistent with our previous findings of arsenic-induced atherosclerosis (Chen et al 1988bChiou et al 1997b;Tseng et al 1996;Wang et al 2002;Wu et al 1989). There have been few studies comparing the prevalence of specific vascular diseases in relation to arsenic exposure in diabetics and nondiabetics.…”

Section: Discussionsupporting

confidence: 92%

“…Other chronic health effects induced by arsenic have also drawn global attention, especially cardiovascular, neurologic, reproductive, and developmental hazards (Chen et al 1997a(Chen et al , 1999. Mortality and morbidity of vascular diseases, including peripheral vascular disease, cerebral infarction, and ischemic heart disease, have been documented to be associated with arsenic levels in drinking water in the arseniasisendemic area (Chen et al 1988bChiou et al 1997b;Tseng et al 1996;Wang et al 2002;Wu et al 1989). The associations between long-term exposure to arsenic and microvascular diseases, including renal disease, retinopathy, and neuropathy, remain to be elucidated.…”

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confidence: 99%

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Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Wang

Chiou

Chen

et al. 2003

Environ Health Perspect

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There is evidence indicating that ingestion of arsenic may predispose the development of diabetes mellitus in arsenic-endemic areas in Taiwan. However, the prevalence of diabetes and related vascular diseases in the entire southwestern arseniasis-endemic and nonendemic areas remains to be elucidated. We used the National Health Insurance Database for 1999-2000 to derive the prevalence of non-insulin-dependent diabetes and related vascular diseases by age and sex among residents in southwestern arseniasis-endemic and nonendemic areas in Taiwan. The study included 66,667 residents living in endemic areas and 639,667 in nonendemic areas, all ≥ 25 years of age. The status of diabetes and vascular diseases was ascertained through disease diagnosis and treatment prescription included in the reimbursement claims of clinics and hospitals. The prevalence of non-insulin-dependent diabetes, age-and gender-adjusted to the general population in Taiwan, was 7.5% (95% confidence interval, 7.4-7.7%) in the arseniasis-endemic areas and 3.5% (3.5-3.6%) in the nonendemic areas. Among both diabetics and nondiabetics, higher prevalence of microvascular and macrovascular diseases was observed in arseniasis-endemic than in the nonendemic areas. Age-and gender-adjusted prevalence of microvascular disease in endemic and nonendemic areas was 20.0% and 6.0%, respectively, for diabetics, and 8.6% and 1.0%, respectively, for nondiabetics. The corresponding prevalence of macrovascular disease was 25.3% and 13.7% for diabetics, and 12.3% and 5.5% for nondiabetics. Arsenic has been suggested to increase the risk of non-insulin-dependent diabetes mellitus and its related micro-and macrovascular diseases.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Wang

Chiou

Chen

et al. 2003

Environ Health Perspect

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137

111

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“…Long-term arsenic exposure is closely associated with adverse health effects, including several vascular disorders Chiou et al 1997;Engel et al 1994;Tseng et al 1995Tseng et al , 1996Wang et al 2002). The possibility that arsenic induces atherosclerosis through its actions on the change of inflammatory-related gene expression needs to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression of Inflammatory Molecules in Circulating Lymphocytes from Arsenic-Exposed Human Subjects

Wu¹,

Chiou²,

Ho³

et al. 2008

Environ. Health Perspect.

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“…Chronic exposure to inorganic forms of it from drinking water and air pollution can cause many types of cancers such as skin cancer, bladder cancer, liver cancer and kidney cancer. In addition to its carcinogenic effects, arsenic has been linked to type II diabetes mellitus [1] and cardiovascular diseases [2], for example atherosclerosis, hypertension [3], and blackfoot disease [4]. The mechanisms of these effects of arsenic on the development of diseases are not known.…”

Section: Introductionmentioning

confidence: 99%

The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation

et al. 2005

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The present study investigates the molecular details of how arsenic trioxide inhibits preadipocyte differentiation and examines the role of Akt/PKB in regulation of differentiation and apoptosis. Continual exposure of arsenic trioxide, at the clinic achievable dosage that does not induce apoptosis, suppressed 3T3-L1 cell differentiation into fat cells by inhibiting the expression of PPARγ and C/EBPα and disrupting the interaction between PPARγ and RXRα, which determines the programming of the adipogenic genes. Interestingly, if we treated the cells for 12 or 24 h and then withdrew arsenic trioxide, the cells were able to differentiate to the comparable levels of untreated cells as assayed by the activity of GAPDH, the biochemical marker of preadipocyte differentiation. Long term treatment blocked the differentiation and the activity of GAPDH could not recover to the comparable levels of untreated cells. Continual exposure of arsenic trioxide caused accumulation in G2/M phase and the accumulation of p21. We found that arsenic trioxide induced the expression and the phosphorylation of Akt/PKB and it inhibited the interaction between Akt/PKB and PPARγ . Akt/PKB inhibitor appears to block the arsenic trioxide suppression of differentiation. Our results suggested that Akt/PKB may play a role in suppression of apoptosis and negatively regulate preadipocyte differentiation.

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Dose-response relationship between peripheral vascular disease and ingested inorganic arsenic among residents in blackfoot disease endemic villages in Taiwan

Cited by 162 publications

References 21 publications

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Prevalence of non-insulin-dependent diabetes mellitus and related vascular diseases in southwestern arseniasis-endemic and nonendemic areas in Taiwan.

Gene Expression of Inflammatory Molecules in Circulating Lymphocytes from Arsenic-Exposed Human Subjects

The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation

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