Gene Expression of Inflammatory Molecules in Circulating Lymphocytes from Arsenic-Exposed Human Subjects

Chronic low level arsenic exposure evokes inflammatory responses and DNA damage

“…Increased secretion of inflammatory biomarkers like IL-8, TNF-␣, and TGF-␣ has been related with As exposure in urothelial cells (Liu et al, 2014). Elevated levels of CD14 and several other inflammatory cytokines were observed to be elevated in isolated lymphocytes from chronic As exposed population reported with atherosclerosis (Wu et al, 2003). In congruence with the above studies we observed that the low As exposed women had elevated expression of CD14 on monocytes which showed a positive correlation with As in groundwater of that area.…”

Mechanisms of action for arsenic in cardiovascular toxicity and implications for risk assessment

“…Lee et al (2005) demonstrated that in vitro sodium arsenite exposure induces the expression of monocyte chemoattractant protein-1 (MCP-1) and IL-6 in vascular smooth muscle Wu et al, 2003). Moreover, the results from Lee et al (2005) demonstrated that administration of antibody against MCP-1 could suppress increased chemotactic activity for human monocytes, intimating MCP-1 released from vascular SMCs by iAs may be involved in initiating atherosclerotic lesions ).…”

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways

“…Interleukin-6 (IL-6), a pleiopotent inflammatory cytokine, and monocyte chemoattractant protein-1 (MCP-1), a monocyte recruiting chemokine, were induced in atherosclerotic lesions and plasma of arsenic-exposed ApoE -/-mice ), circulating lymphocytes of arsenic-exposed human subjects (Wu et al 2003) and arsenite-treated vascular smooth muscle cells (VSMC) . Vascular endothelial growth factor (VEGF) was induced by exposure to non-toxic concentrations of arsenic, which preferentially enhances angiogenesis (Kao et al 2003;Meng et al 2010), and has been shown to be important for the arsenite-induced endothelial cell permeability (Bao and Shi 2010).…”