Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants

Denjean, A.; Guimarães, Hercília; Migdał, Marek; Miramand, J.L.; Dehan, M; Gauttier, C.

doi:10.1016/s0022-3476(05)81973-0

Cited by 68 publications

(40 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,7 In those studies, the infants were older than ours and they had higher baseline R rs values. It has been shown that the mean baseline R rs values are higher in infants with chronic lung disease who were more than 19 days old, compared to ventilatordependent infants with respiratory distress syndrome with the same size endotracheal tube.…”

Section: Discussionmentioning

confidence: 60%

“…It was believed that improvement was related to bronchodilation of the small peripheral airways, resulting in recruitment of new alveoli, and an increase in lung volume. Denjean et al 2 reported a 67% increase in C rs and a 33% decrease in R rs at 30 min. They used MDI and a spacer, connected to a manual bag system, and delivered salbutamol via manual ventilation over 30 sec, in a dose-related response study.…”

Section: Discussionmentioning

confidence: 96%

“…1,2,3 Jet, ultrasonic and low-flow nebulizers and metered dose inhalers (MDI) and spacers have been used to deliver albuterol in ventilated newborns. [1][2][3][4][5][6] A number of studies have demonstrated improvement in compliance and resistance with albuterol administered by either nebulizer (NEB) or MDI in ventilated premature infants. 1,2,[6][7][8] Albuterol given via NEB has been compared with placebo 1 and ipratropium bromide.…”

Section: Introductionmentioning

confidence: 99%

“…1,2,[6][7][8] Albuterol given via NEB has been compared with placebo 1 and ipratropium bromide. 6 MDIs have been studied using different doses of albuterol, 2 and have been compared with intravenous albuterol. 7 Compliance and resistance have been measured pre-and post-administration of albuterol via MDI.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bronchodilator delivered by metered dose inhaler and spacer improves respiratory system compliance more than nebulizer-delivered bronchodilator in ventilated premature infants

1999

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bronchodilator delivered by metered dose inhaler and spacer improves respiratory system compliance more than nebulizer-delivered bronchodilator in ventilated premature infants

1999

View full text Add to dashboard Cite

“…Salbutamol resulted in a dose-dependent improvement in lung mechanics [96]. Synergism was seen with salbutamol and ipratropium bromide [97], but not metaproterenol and atropine [98].…”

Section: Bronchodilatorsmentioning

confidence: 90%

Medicines used in respiratory diseases only seen in children

Lenney¹,

Al²,

Bont³

et al. 2009

European Respiratory Journal

View full text Add to dashboard Cite

Detailed literature searches were carried out in seven respiratory disease areas. Therapeutic evidence for efficacy of medicinal products was assessed using the Grades of Recommendation, Assessment and Evaluation (GRADE) methodology, as well as an assessment of safety and side-effects.Systemic corticosteroids may reduce the development of bronchopulmonary dysplasia but have serious side-effects. Antioxidants need further study to demonstrate whether they have long-term benefits. Treatments for acute bronchiolitis have shown little benefit but new antiviral and monoclonal antibodies need further assessment. Well-constructed studies are needed to confirm the value of inhaled corticosteroids and/or montelukast in the management of viralinduced wheeze. Corticosteroids are the treatment of choice in croup. Minimal or no information is available for the treatment of congenital lung abnormalities, bronchiolitis obliterans and interstitial lung disease.

show abstract

Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia

et al. 1996

View full text Add to dashboard Cite

Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants

Cited by 68 publications

References 14 publications

Bronchodilator delivered by metered dose inhaler and spacer improves respiratory system compliance more than nebulizer-delivered bronchodilator in ventilated premature infants

Bronchodilator delivered by metered dose inhaler and spacer improves respiratory system compliance more than nebulizer-delivered bronchodilator in ventilated premature infants

Medicines used in respiratory diseases only seen in children

Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia

Contact Info

Product

Resources

About