Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia

Breath-Triggered Drug Release System for Preterm Neonates

“…As mentioned before, aerosol reaches the alveoli only in the first half of the inspiratory phase [ 30 ], leading to an increased aerosol loss of up to 90% for the aerosol delivery during the entire respiratory phase in preterm neonates without triggered administration. This high loss corresponds well to previous reports about low depositions in infants [ 51 , 52 , 53 , 54 , 55 , 56 ], in some cases, less than 1% of the nominal dose [ 55 , 57 ]. Thus, breath-triggered drug release, especially for preterm neonates, is highly desirable.…”

Delivery of Salbutamol Pressurized Metered-Dose Inhaler Administered Via Small-Volume Spacer Devices in Intubated, Spontaneously Breathing Rabbits

“…Our results in intubated but spontaneously breathing rabbits with normal lungs confirm that delivery of salbutamol to small lungs is low. The lung deposition observed in this study for the Aerochamber-Infant is similar to those previously reported in human in vivo scintigraphic studies (6,7). Deposition was statistically increased when using the NESspacer rather than the two other spacer devices, with a mean lung and body deposition of 5.40 Ϯ 2.40%.…”

Lung aerosol deposition in suckling infants

“…The deposition of aerosol in the lungs using pacifiers and nasal breathing was similar to that reported previously in infants 2 4 18. It is thus reasonable to conclude that sucking on a pacifier, while inhaling aerosol nasally, does not appear to have an adverse effect on aerosol delivery to the lower respiratory tract using a small volume nebuliser for aerosol administration.…”