Dose-mortality Studies for Mice Irradiated with X-rays, Gamma-rays and 15 MeV Neutrons

Broerse, J.J.

doi:10.1080/09553006914550201

Cited by 25 publications

(2 citation statements)

References 9 publications

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“…Doses at midline tissue were 3 and 7 Gy, given at 0.4-Gy:min. In various mice strains in which gastrointestinal damage has been evaluated after irradiation, such damage occurs at doses of 10 Gy or more (24)(25)(26). The LD 50:30 for the g -irradiated B6D2F1:J strain is 9.03 Gy (95% con dence limits [C.L.]…”

Section: Radiation and Dosimetrymentioning

confidence: 99%

Sublethal γ-Radiation Decreases Resistance of Mice to Intragastric Shigella sonnei Challenge

King¹,

Elliott²,

Landauer³

et al. 2002

Microbial Ecology in Health and Disease

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This study was performed to determine the degree to which 6 0 Co-g irradiation alters the susceptibility of conventional mice to intragastric challenge with Shigella sonnei as measured by survival, body weight, performance, and microbiology assays of intestinal ora. Female B6D2F1:J mice were given S. sonnei intragastrically 4 days after sublethal 60 Co-g irradiation. Survival and body weight after irradiation and pathogen challenge and under control conditions were examined for 30 days while motor coordination, using the inverted-screen test, was examined intermittently during the 30-day period. Survival and weight loss in irradiated and challenged mice depended on the combined doses of the two insults. The incidence of mortality in the latter mice was never 100%, even at a high sublethal radiation dose (7-Gy) and a S. sonnei dose of 1.2 ½10 9 CFU. Depending on the combined doses of the two insults, weight loss in surviving mice was generally recovered within 30 days. 1.2 ½ 10 8 CFU S. sonnei evoked mortality in four of 12 non-irradiated but challenged mice (33%) but in no other case did S. sonnei alone evoke mortality. Radiation alone evoked no mortality. Radiation alone signi cantly reduced body weight when mice were individually weighed on a daily basis. Performance on the inverted-screen test was signi cantly decremented in irradiated, challenged mice. S. sonnei was always recovered from the heart blood of deceased irradiated-challenged mice but was variably recovered from ileum or caecum and seldom recovered from formed, expressed stools. We conclude that conventional mice can be made susceptible to an intragastric challenge of S. sonnei by sublethal doses of ionizing radiation.

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Section: Radiation and Dosimetrymentioning

confidence: 99%

Sublethal γ-Radiation Decreases Resistance of Mice to Intragastric Shigella sonnei Challenge

King¹,

Elliott²,

Landauer³

et al. 2002

Microbial Ecology in Health and Disease

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“…Hendry et al (1982) studying apotosis in the mouse intestine after 14MeV or 600 MeV neutrons and Higgins et al (1981) studying survival of V79 cells after 2 5 and 14-3 MeV neutrons observed no effect of neutron dose rate. However, some dose rate dependence with 15 MeV neutrons was observed on both 5 day or 30 day mortality of mice (Broerse 1969) and on damage to rat skin or to rhabdomyosarcoma (Kal 1974). Van Dam et al (1983) have shown a small dependence on dose rate for 20MeV neutrons of postirradiation growth rate in bean roots, and the authors claimed that the influence of dose rate was comparable for neutrons and 7-rays over the same range of low dose rates (06 Gymin-1 to 02 Gyh-).…”

Section: Introductionmentioning

confidence: 96%

The Effect of Neutron Dose Rate on Jejunal Crypt Survival

Griffin¹,

Hornsey

1985

International Journal of Radiation Biology and Related Studies

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The effect of dose rate of fast neutrons over a range from 0.02 Gy/min to 22.5 Gy/min on the survival of mouse jejunal crypts was investigated. A small but significant decrease in sensitivity with decrease in dose rate was observed. A 10-fold decrease in dose rate gave a decrease in effectiveness equivalent to 0.39 Gy. The sensitivity to changes in neutron dose rate is much smaller than the sensitivity to changes in dose rate of photons.

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Biological Effects of Neutrons

Broerse

1980

Advances in Radiation Protection and Dosimetry in Medicine

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Dose-mortality Studies for Mice Irradiated with X-rays, Gamma-rays and 15 MeV Neutrons

Cited by 25 publications

References 9 publications

Sublethal γ-Radiation Decreases Resistance of Mice to Intragastric Shigella sonnei Challenge

Sublethal γ-Radiation Decreases Resistance of Mice to Intragastric Shigella sonnei Challenge

The Effect of Neutron Dose Rate on Jejunal Crypt Survival

Biological Effects of Neutrons

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