Dose minimization study of oxytocin in early labor in sows: Uterine activity and fetal outcome

Mota-Rojas, Daniel; Nava-Ocampo, Alejandro A; Ortega, María Elena Trujillo; Velázquez-Armenta, Yadira; Ramírez-Necoechea, R.; Martı́nez-Burnes, Julio; Alonso-Spilsbury, y María

doi:10.1016/j.reprotox.2005.02.005

Cited by 41 publications

(39 citation statements)

References 20 publications

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“…In a dose-response study of oxytocin administered to sows early during labor, we recently demonstrated that oxytocin 0.083 IU/kg significantly decreased the mortality rate of piglets compared to higher doses (Mota-Rojas et al, 2005). Our findings supported the possibility that certain dose regimens of oxytocin may increase offspring survival rate in pigs.…”

Section: Introductionsupporting

confidence: 74%

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Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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Oxytocin is extensively used to induce or augment uterine contractions, especially to facilitate the third stage of labor in humans. Administration of oxytocin to parturient sows reduces duration of labor whereas mortality of the offspring may remain unchanged. This study aimed to evaluate whether time of administration of oxytocin during parturition may alter the uterine response and fetal outcomes. Two hundred parturient sows were randomly assigned to intramuscularly receive either saline solution (control group) or oxytocin 0.083 IU/kg immediately after the delivery of the 1 st , 4 th or 8 th piglet (groups O-1, O-4 and O-8, respectively). Uterine effects and fetal outcomes were registered in all groups. The duration of labor was 20-40 min shorter (P < 0.0001) and time interval between babies was reduced by 3-5 min (P < 0.0001) in the three groups receiving oxytocin. The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased. In group O-8, we observed approximately 70% less meconium-stained piglets and intrapartum deaths than in the control group. In conclusion, oxytocin administered at early phases of parturition to sows may increase duration and intensity of uterine contractions as well as adverse fetal outcomes.

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Section: Introductionsupporting

confidence: 74%

“…The latter were classified according to criteria previously described in detail elsewhere (Mota-Rojas et al, 2002;Mota-Rojas et al, 2005). Briefly, type-I stillbirths occur in the prepartum period whereas type-II stillbirths occur during parturition and they are generally associated with anoxia and dystocia.…”

Section: Methodsmentioning

confidence: 99%

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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“…Monitoring included the recording of the period of time from expulsion of the first to the last piglet, being careful to measure the real interval between each piglet (Mota et al, 2005a;b). The overall duration of parturition was registered as the time elapsed (min) from the rupture of amniotic membrane to the expulsion of placenta.…”

Section: Methodsmentioning

confidence: 99%

“…The overall duration of parturition was registered as the time elapsed (min) from the rupture of amniotic membrane to the expulsion of placenta. Stillbirths were classified a s type I or before parturition deaths and intra-partum or type I1 following criteria previously described by Mota-Rojas et al (2002;2005a;b).…”

Section: Methodsmentioning

confidence: 99%

“…Farrowing duration influences stillbirth rates, mainly due t o intra-partum asphyxia (Herpin et al, 1996, Lucia et al, 2002 leading to the presence of meconium in the amniotic fluid, used as an indicator of perinatal asphyxia (AlonsoSpilsbury et al, 2005) Recent studies with the use of cardiotocography had determined the effect of uterotonics i n the myometrial activity and subsequent farrowing performance in pigs (Mota-Rojas et al, 2005a;c). Electronic foetal monitoring and in uiuo uterine electromyographic activity from spontaneous farrowings in sows will help provide additional information in these regards.…”

Section: Introductionmentioning

confidence: 99%

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Foetal Monitoring, Uterine Dynamics and Reproductive Performance in Spontaneous Farrowings in Sows

Olmos-Hernández

Ortega

Alonso-Spilsbury

et al. 2008

Journal of Applied Animal Research

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Olmos-Hernandez, A., Trujillo-Ortega, M.E., Alonso-Spilsbury, M., Sanchez-Aparicio, P., Ramirez-Necoechea, R. and Mota-Rojas, D. 2008 FCF decelerations, (0.90, P=0.004), which agrees too with a large average number of intra-partum stillbirths (0.90) found. The present study establishes the basic uterine dynamics of eutocic parturitions which may help in swine obstetrics to design uterotonic treatments reducing the stillbirth rate due to asphyxia. These findings emphasize a need for farrowing supervision, especially for first and over fifth parity sows.

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Uterine motility in the reptileAnolis carolinensis: interactive effects of tension, prostaglandins, calcium, and vasotocin

et al. 2006

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Uteri of Anolis carolinensis exhibited spontaneous rhythmic contractions in vitro. Addition of arginine vasotocin (AVT) caused an immediate, strong, tonic contraction followed by rhythmic contractions with the same frequency as spontaneous contractions but of a greater amplitude. At low tension (1.5 g) the AVT-induced tonic contraction was blocked by low dose of indomethacin, suggesting that it is influenced by calcium rather than prostaglandins (PGs). An increase in tension (from 1.5 to 15 g) reduced the duration of the AVT-induced tonic contraction; this stretch-induced decrease was also blocked by indomethacin. Stretch also decreased the duration of the rhythmic contractions, but this stretch effect was not inhibited by indomethacin. The rest interval between rhythmic contractions was decreased by PGF2alpha and PGE2, and indomethacin or stretch blocked these PG effects. Indomethacin, AVT, or stretch alone did not affect PGF2alpha secretion from AVT-treated uteri. Stretch also reduced PGF2alpha secretion from AVT-treated uteri, an effect inhibited by indomethacin.

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Dose minimization study of oxytocin in early labor in sows: Uterine activity and fetal outcome

Cited by 41 publications

References 20 publications

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Foetal Monitoring, Uterine Dynamics and Reproductive Performance in Spontaneous Farrowings in Sows

Uterine motility in the reptileAnolis carolinensis: interactive effects of tension, prostaglandins, calcium, and vasotocin

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