Dose escalation of chart in non-small cell lung cancer: is three-dimensional conformal radiation therapy really necessary?

McGibney, C.; Holmberg, Ola; McClean, Brendan; Williams, Charles C.; McCrea, P. C.; Sutton, Philip; Armstrong, John G.

doi:10.1016/s0360-3016(99)00095-4

Cited by 36 publications

(8 citation statements)

References 17 publications

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“…Conformal three-dimensional radiotherapy improves on conventional two-dimensional radiotherapy by optimising target coverage and by reducing the exposure of normal tissues to high-dose radiation [298]. The European Organization for Research and Treatment of Cancer (EORTC) guidelines for treatment planning of high-dose radiotherapy in lung cancer advocates the use of three-dimensional radiotherapy planning [299].…”

Section: Statementmentioning

confidence: 99%

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Brunelli¹,

Charloux²,

Bolliger³

et al. 2009

European Respiratory Journal

752

550

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A collaboration of multidisciplinary experts on the functional evaluation of lung cancer patients has been facilitated by the European Respiratory Society (ERS) and the European Society of Thoracic Surgery (ESTS), in order to draw up recommendations and provide clinicians with clear, up-to-date guidelines on fitness for surgery and chemo-radiotherapy.The subject was divided into different topics, which were then assigned to at least two experts. The authors searched the literature according to their own strategies, with no central literature review being performed. The draft reports written by the experts on each topic were reviewed, discussed and voted on by the entire expert panel. The evidence supporting each recommendation was summarised, and graded as described by the Scottish Intercollegiate Guidelines Network Grading Review Group. Clinical practice guidelines were generated and finalised in a functional algorithm for risk stratification of the lung resection candidates, emphasising cardiological evaluation, forced expiratory volume in 1 s, systematic carbon monoxide lung diffusion capacity and exercise testing.Contrary to lung resection, for which the scientific evidences are more robust, we were unable to recommend any specific test, cut-off value, or algorithm before chemo-radiotherapy due to the lack of data. We recommend that lung cancer patients should be managed in specialised settings by multidisciplinary teams.

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Section: Statementmentioning

confidence: 99%

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Brunelli¹,

Charloux²,

Bolliger³

et al. 2009

European Respiratory Journal

752

550

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show abstract

“…A simple increase in the dose by giving additional fractions is limited by the tolerance doses of the surrounding tissue. The use of 3D-conformal radiotherapy significantly reduces doses to the spinal cord, heart and esophagus but does not improve lung sparing [ 19 ]. Lung has been identified as the dose limiting organ at risk in dose escalation trials [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Correction of patient positioning errors based on in-line cone beam CTs: clinical implementation and first experiences

et al. 2006

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The cone beam CT attached to a LINAC allows the acquisition of a CT scan of the patient in treatment position directly before treatment. Its image quality is sufficient for determining target point correction vectors. With the presented workflow, a target point correction within a clinically reasonable time frame is possible. This increases the treatment precision, and potentially the complex patient fixation techniques will become dispensable.

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“…Теоретически, нетрадиционные режимы ускоренного фракционирования обладают достаточной способностью решать эту проблему С. McGibney и соавт. [33] показали, что комбинация трехмерной конформной ЛТ с ограничением воздействия на здоровые ткани позволяет осуществлять эскалацию ЛТ в режиме CHART при сохранении оптимального воздействия на опухоль.…”

Section: обзоры литературыunclassified

Nontraditional radiotherapy regimens for non-small-cell lung cancer

Ragulin¹,

Gogolin²

2016

Onkol. Z. im. P.A. Gercena

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Медицинский радиологический научный центр им. А.Ф. Цыба-филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России, Обнинск, Россия Лучевая терапия (ЛТ) играет важную роль в лечении немелкоклеточного рака легкого (НМРЛ) в связи с тем, что у значительного числа больных имеются противопоказания к хирургическому лечению. Однако результаты консервативного лечения НМРЛ нельзя считать удовлетворительными. Современные методы реализации ЛТ позволяют целенаправленно воздействовать на опухоль и свести к минимуму отрицательное влияние на окружающие здоровые ткани. Это создает возможность эскалации дозы и оптимизации радиотерапевтического воздействия для каждого больного. Особое значение это приобретает у больных, имеющих противопоказания к химиотерапии, где есть необходимость увеличения лечебного воздействия самостоятельной радикальной ЛТ. Результаты исследований эффективности различных режимов фракционирования показали, что применение ускоренных режимов является наиболее перспективным направлением в лечении НМРЛ. Ключевые слова: рак легкого, лучевая терапия, нетрадиционное фракционирование.

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Dose escalation of chart in non-small cell lung cancer: is three-dimensional conformal radiation therapy really necessary?

Cited by 36 publications

References 17 publications

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Correction of patient positioning errors based on in-line cone beam CTs: clinical implementation and first experiences

Nontraditional radiotherapy regimens for non-small-cell lung cancer

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