Dose Effects of Raw Soyabean Flour on Pancreatic Growth

Morgan, R. G. H.; Crass, R. A.; Oates, Phillip S.

doi:10.1007/978-1-4757-0022-0_4

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Soybean and other legumes containing active protease inhibitors depress growth in rats compared to analogous feeding of inhibitor-free soybeans. Growth inhibition and the accompanying pancreatic hypersecretion of trypsin and chymotrypsin, pancreatic hypertrophy, and pancreatic adenoma are presumably partly due to the antitryptic and antichymotryptic activities of the inhibitors, since toasting soy flour, which inactivates most of the inhibitors, largely prevents pancreatic enlargement and related changes (Gumbmann et al, 1986;Liener and Hasdai, 1986; Morgan et al, 1986). Although the possible significance of trypsin inhibitors for human health is yet to be resolved (Hathcock, 1991;Liener et al, 1988;Toskes, 1986; Wormsley and Roebuck, 1988), the concern, if any, could be avoided by eliminating the inhibitors from the diet.…”

Section: Soybean Inhibitors Of Digestive Enzymesmentioning

confidence: 99%

Improvement in the safety of foods by sulfhydryl-containing amino acids and peptides. A review

Friedman¹

1994

J. Agric. Food Chem.

109

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Section: Soybean Inhibitors Of Digestive Enzymesmentioning

confidence: 99%

Improvement in the safety of foods by sulfhydryl-containing amino acids and peptides. A review

Friedman¹

1994

J. Agric. Food Chem.

109

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“…As one of the major antinutritional factors present in soybean, soybean trypsin inhibitors (TIs) must be fully deactivated in processed food and feed products made from soybean, because active TIs can induce several diseases of humans and animals, such as growth inhibition, pancreatic hypertrophy and hyperplasia in rats, mice and chickens 1, 2. Soybean TIs can be divided into two main classes, namely Kunitz (KTI) and Bowman–Birk (BBTI) TIs.…”

Section: Introductionmentioning

confidence: 99%

Changes in inhibitory activity and secondary conformation of soybean trypsin inhibitors induced by tea polyphenol complexation

et al. 2009

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BACKGROUND: Tea polyphenol (TP) is a new food additive for antioxidant application, while soybean is an important resource for food and feed processing. It is therefore of rational and practical significance to investigate the influence of TP on soybean trypsin inhibitors (TIs). The aim of this study was to determine the effects of TP on the inhibitory activity of Kunitz (KTI) and Bowman-Birk (BBTI) TIs and to reveal the relationship between the inhibitory activity and conformation of KTI and BBTI by measurement of circular dichroism (CD) spectra.

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“…Raw soya flour contains high levels of trypsin inhibitor (Rackis and Anderson, 19641, and in the rat this diet causes marked pancreatic growth, by both hypertrophy and hyperplasia of the acinar cells. This growth is probably the result of the sustained release of cholecystokinin, a powerful stimulant for pancreatic enzyme secretion and a trophic hormone for the pancreas (Rackis et al, 1963;Folsch et al, 1974;Melmed et al, 1976;Crass and Morgan, 1981;Morgan et al, 1986). With prolonged exposure, atypical acinar cell foci develop, progressing to adenoma and eventually carcinoma (Levison et 1979; McGuiness et al, 1980;Longnecker and Morgan, 1985).…”

Section: Introductionmentioning

confidence: 99%

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

Morgan

1990

Am. J. Anat.

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Nuclei of pancreatic cells were isolated by trypsin-detergent digestion of fresh tissue and stained with propidium iodide, and nuclear DNA was measured by flow cytometry. Samples were isolated from mice fed either chow or raw soya flour (RSF) for periods ranging from 1 day to 48 weeks, beginning at 4 weeks of age. In chow-fed mice, the pancreas contained about 80% diploid (2N) and 20% tetraploid (4N) cells at the start of the study, but tetraploidy gradually increased to about 40% 2 weeks later (6 weeks of age) and remained at this level from that time onwards. Low levels of octaploid nuclei (8N) were also present in some animals after 2 weeks. In RSF-fed mice, about 20% tetraploid nuclei were also present for 1 and 2 days after starting RSF, but by 4 days tetraploidy had increased significantly to 40% and by 14 days had further increased to 50%. This level was significantly higher than that seen in chow-fed animals and was maintained for up to 48 weeks. Significantly higher numbers of octaploid nuclei were also present in the RSF-fed animals. In both chow- and RSF-fed mice, most cells were mononuclear, averaging 70% in chow-fed and 64% in RSF-fed animals. This difference was significant. This study shows that the mouse pancreas differs from the rat pancreas in the absence of a large population of binucleate acinar cells and the presence of considerable nuclear tetraploidy. Raw soya flour feeding leads to significant changes in these features, but in this species these changes do not appear to predispose to neoplasia.

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Dose Effects of Raw Soyabean Flour on Pancreatic Growth

Cited by 8 publications

References 22 publications

Improvement in the safety of foods by sulfhydryl-containing amino acids and peptides. A review

Improvement in the safety of foods by sulfhydryl-containing amino acids and peptides. A review

Changes in inhibitory activity and secondary conformation of soybean trypsin inhibitors induced by tea polyphenol complexation

Changes in numbers of pancreatic acinar cell nuclei and in DNA content during raw soya flour feeding in mice

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