Dose-dependent hyporreactivity to phytohemagglutinin in systemic lupus erythematosus

Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus.

“…However, at a suboptimal concentration (1 ,ug/ml) the responses were significantly decreased when secreted protein was measured (P < 0.05), though not when DNA synthesis was measured. This supports the observation of Malave et al (27), who described decreased responses of PBMC from SLE patients to suboptimal concentrations of PHA. In contrast to the finding in normal subjects, when the effect of incubation before stimulation of SLE mononuclear cells was examined, either at optimal or suboptimal concentrations, there was little or no increase in the response.…”

Fractionation of cells on a discontinuous Ficoll gradient. Study of subpopulations of human T cells using anti-T-cell antibodies from patients with systemic lupus erythematosus.

“…Furthermore, they have been found to have a reduction in T cells (24,25) and T-cell functions (26)(27)(28)(29)(30). Finally, anti-lymphocyte and anti-T cell-antibodies have been found in patients with SLE (1)(2)(3)(4)(5)(6)(7)(8)(9) toxicity, implicating Fc receptor-bearing cells.…”

Studies of Immune Functions of Patients with Systemic Lupus Erythematosus

“…(25,27,51), whereas noncytotoxic antibodies were more likely to be of the IgG class (34,52). Furthermore, antibodies of the IgG class have been demonstrated to functionally impair certain T-cell responses such as ability to proliferate in response to mitogens and allogeneic cells (5,32,34,53,54). It is, however, conceivable that previous reports of IgG anti-T-cell antibodies may have also involved binding of IgG-containing immune complexes binding to T cells by way of the Fc receptor on some T cells.…”