Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats

Bhadauria, Monika

doi:10.1016/j.etp.2009.08.006

Cited by 55 publications

(38 citation statements)

References 29 publications

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“…However, emodin effectively reversed toxic events induced by acetaminophen in Bhadauria's research (Bhadauria, 2010), which were opposite with the results got in this manuscript. However, this research was carried out using in vitro methods while that was in vivo methods applied in Bhadauria group.…”

Section: Cytotoxicity Of Tsg Emodin and Physcioncontrasting

confidence: 79%

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Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

Xie

Mao

et al. 2011

Journal of Ethnopharmacology

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Section: Cytotoxicity Of Tsg Emodin and Physcioncontrasting

confidence: 79%

“…Recent research showed that emodin effectively reversed toxic events induced by acetaminophen (Bhadauria, 2010). However, another research reported emodin was one of the important chemical constituents leading to liver cell damage (Zhang et al, 2010).…”

mentioning

confidence: 98%

Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

Xie

Mao

et al. 2011

Journal of Ethnopharmacology

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“…Thus, it can be stated that tarvada roots have shown more potent hepatoprotective activity as a prophylactic and anti-hepatotoxic agent than as a therapeutic agent. Review of the literature revealed that anthraquinone glycosides, such as rubiadin (Rao et al, 2006) and emodin (Bhadauria, 2010), tannins and phenolic compounds (Atta et al, 2006) have potent hepatoprotective activity. Flavone glycosides such as hirsutrin, avicularin, quercetin, rutin (Janbaz et al, 2002) and apigenin (Sayed et al, 2011) have significant antioxidant and hepatoprotective activities.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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“…Recent studies demonstrated that emodin exhibits antioxidative stress activities [11,12]. Given that CS-induced oxidative stress plays a critical role in lung inflammation and damage, we hypothesized that emodin might have protective effects on CS-induced lung injury.…”

Section: Introductionmentioning

confidence: 99%

Emodin Attenuates Cigarette Smoke Induced Lung Injury in a Mouse Model via Suppression of Reactive Oxygen Species Production

Xue

Shi

Liang

et al. 2015

J Biochem Mol Toxicol

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Emodin has antioxidative activities. Here, we investigated the effects of emodin on cigarette smoke (CS)-induced acute lung inflammation. Mice (C57BL/6) were exposed to CS. Emodin was administrated with intraperitoneal bolus injection of emodin (20 or 40 mg/kg) daily 1 h before CS exposure. Emodin inhibited CS-induced inflammatory cells infiltration in mouse lungs, especially at 40 mg/kg. Moreover, emodin resulted in significant reductions in total bronchoalveolar lavage fluid (BALF) cells, as compared with air exposure control, coupled with decreases in BALF cytokines. The activities of superoxide dismutase, catalase, and glutathione peroxidase were remarkably enhanced by emodin in CS-exposed mice. Emodin enhanced CS-induced expression of heme oxygenase-1 and nuclear factor-erythroid 2-related factor-2 (both are antioxidative genes) at both mRNA and protein levels, and profoundly promoted their activities in CS-treated mice. Collectively, our results suggested that emodin protects mouse lung from CS-induced lung inflammation and oxidative damage, most likely through its antioxidant activity.

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Dose-dependent hepatoprotective effect of emodin against acetaminophen-induced acute damage in rats

Cited by 55 publications

References 29 publications

Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Emodin Attenuates Cigarette Smoke Induced Lung Injury in a Mouse Model via Suppression of Reactive Oxygen Species Production

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