Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats

Pechlivanova, Daniela; Tchekalarova, Jana; Nikolov, Roumen; Yakimova, K

doi:10.1016/j.bbr.2010.01.037

Cited by 48 publications

(32 citation statements)

References 35 publications

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“…The duration used in this study, 5 minutes, is commonly used by other researchers (Meerlo et al, 1996; Pechlivanova et al, 2010; Careau et al, 2012); however it may be that longer durations would be better suited to investigate general locomotor activity. It may also be worthwhile to investigate incremental changes, i.e.…”

Section: Discussionmentioning

confidence: 99%

Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity

et al. 2014

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Manganese (Mn) is an essential trace element, but excess exposure leads to accumulation in biological tissues, including the brain. Chronically high Mn levels in the brain are neurotoxic and can result in a progressive, irreversible neurological disorder known as manganism. Manganism has signs and symptoms similar to, but distinguishable from idiopathic Parkinson’s disease, which include both psychological and motor disturbances. Evidence suggests that Mn exposure impacts neurotransmitter levels in the brain. However, it remains unclear if subacute, low-level Mn exposure resulted in alterations in neurotransmitter systems with concomitant behavioral deficits. The current study used high performance liquid chromatography to quantify neurotransmitter levels in rat striatum (STR), substantia nigra (SN), and hippocampus (HP). Subacute Mn exposure via i.p. injection of 15 mg Mn/kg as MnCl2 caused significantly increased dopamine (DA) levels in the STR. The enhancement was accompanied by significantly elevated levels of the DA metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the STR. In addition, levels of HVA were significantly increased in the SN and HP. These data indicate that subacute, low-level Mn exposure disrupts multiple neurotransmitter systems in the rat brain which may be responsible, in part, for observed locomotor deficits.

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Section: Discussionmentioning

confidence: 99%

Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity

et al. 2014

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“…Open field test was performed as previously described [31]. The open field apparatus was a black box (height: 40 cm, length: 100 cm, and width: 100 cm) containing 25 equal squares regions that were defined by lines on the floor of the box.…”

Section: Methodsmentioning

confidence: 99%

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Shen

Zhang

Deng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal-regulated protein kinase (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1 g/kg) normalized their depression-related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS-treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1/2, CREB) were upregulated in the hippocampus.

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“…At the same time, the available evidence supports the idea that understanding co-thermoregulation is vital to achieve optimal social functioning. Thermoregulation has further been implicated in (mental) health, such as depression (Pechlivanova et al, 2010), insomnia (Bach et al, 2002; Van den Heuvel et al, 2004; Pechlivanova et al, 2010), anxiety (Parry, 2007), and many others. Furthermore, physiological processes related to thermoregulation (like catabolization of Brown Adipose Tissue ) have become linked to tumor growth (Shellock et al, 1986; Lee et al, 2010) or late onset obesity (Himms-Hagen, 1979, 1989, 1990; Van Marken Lichtenbelt et al, 2009).…”

Section: From Speculation To Application: the Role Of Technological Amentioning

confidence: 99%

Modernizing Relationship Therapy through Social Thermoregulation Theory: Evidence, Hypotheses, and Explorations

et al. 2017

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In the present article the authors propose to modernize relationship therapy by integrating novel sensor and actuator technologies that can help optimize people’s thermoregulation, especially as they pertain to social contexts. Specifically, they propose to integrate Social Thermoregulation Theory ( IJzerman et al., 2015a ; IJzerman and Hogerzeil, 2017 ) into Emotionally Focused Therapy by first doing exploratory research during couples’ therapy, followed by Randomized Clinical Trials (RCTs). The authors thus suggest crafting a Social Thermoregulation Therapy (STT) as enhancement to existing relationship therapies. The authors outline what is known and not known in terms of social thermoregulatory mechanisms, what kind of data collection and analyses are necessary to better understand social thermoregulatory mechanisms to craft interventions, and stress the need to conduct RCTs prior to implementation. They further warn against too hastily applying these theoretical perspectives. The article concludes by outlining why STT is the way forward in improving relationship functioning.

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Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats

Cited by 48 publications

References 35 publications

Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity

Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Modernizing Relationship Therapy through Social Thermoregulation Theory: Evidence, Hypotheses, and Explorations

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