Dose-dependent cholesterol-lowering effects of D-003 on normocholesterolemic rabbits

Gámez, Rafael; Mendoza, Sarahí; Más, Rosa; Mesa, Rosario; Castaño, Gladys; Marrero, David G.

doi:10.1016/s0021-9150(00)80593-6

Cited by 11 publications

(9 citation statements)

References 16 publications

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“…The presence of a homologous series of very long chain fatty acids in the material used in this study, i.e., cane wax from Egypt, contrasts with the absence of similar compounds documented by previous studies (Delange et al, 2002;Gamez et al, 2000). It is difficult to say whether this striking difference is caused by differences in the geographical origin of the analyzed cane (Egyptian cane in our case, Cuban cane in the case of Gonzales et al, 2002), or if it can be ascribed to different instrumentation and methodology.…”

Section: Resultscontrasting

confidence: 99%

“…A natural mixture of higher primary aliphatic acids (24:0 to 36:0) was obtained from sugar cane (Saccharum officinarum L.) wax (Gonzales et al, 2002). This product was found to be responsible for some biological properties related to health, such as antioxidant and cholesterol-lowering effects, determined in both in vivo and in vitro models (Gamez et al, 2000;Rodriguez et al, 2004), beneficial effects on platelet aggregation in healthy volunteers (Arruzazabala et al, 2005), as well as antiplatelet and antithrombotic activities (Molina et al, 2000;Mas, 2004). The nutritional significance and metabolism of very long chain fatty alcohols and acids from sugar cane has recently been reviewed (Hargrove et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Identification of very long chain fatty acids from sugar cane wax by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy

Řezanka

Sigler

2006

Phytochemistry

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Section: Resultscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of very long chain fatty acids from sugar cane wax by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy

Řezanka

Sigler

2006

Phytochemistry

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“…In an experiment on normocholesterolemic rabbits, D-003 (5 to 200 mg/kg/day) for 30 days showed a reversible and dose-dependent decrease in circulating concentrations of TC and LDL-C [20]. Additionally, HDL-C concentrations were increased, but not in a dose-dependent manner.…”

Section: Evidence From Animal Studiesmentioning

confidence: 95%

D-003 (Saccharum officinarum): The forgotten lipid-lowering agent

Awad

Penson

Banach

2016

Pharmacological Research

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ABSTRACT:Reduction of elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), is essential in primary and secondary prevention of cardiovascular disease (CVD). Therefore there is still a large need for new effective drugs, which would be able to essentially reduce LDL-C and in the consequence CV residual risk.D-003 is a mixture of high aliphatic primary acids purified from sugarcane (Saccharum officinarum) wax. It showed promising hypocholesterolemic effects in both animal and human studies; it significantly lowers both serum total cholesterol (TC) and LDL-C, and increases high-density lipoprotein cholesterol (HDL-C). In addition, it showed a favorable safety profile. In this review, we evaluated the profile of D-003 as a lipid-lowering agent based on data from available preclinical and clinical studies.

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“…[6][7][8][9] Also, D-003 administered from 5 to 50 mg/day has shown cholesterol-lowering effects in healthy volunteers and patients with Type II hypercholesterolemia causing reduction of serum LDL-C and TC, while markedly raising HDL-C. [10][11][12] On the other hand, D-003 orally administered also induces anti-platelet effects in animal models and human beings, [12][13][14][15][16][17] which appears to be mediated through reduced thromboxane A 2 levels and increased prostacyclin values. 15,16 Thus, D-003 shows a pharmacological profile suggesting that it could be a promising agent for treating atherothrombotic diseases, as expected from its cholesterol-lowering and anti-platelet effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of D-003 on Hepatic Drug-Metabolizing Enzyme Activities in Rats

Gámez

Rodeiro

González

et al. 2004

Journal of Medicinal Food

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D-003 is a mixture of very-long-chain aliphatic acids with cholesterol-lowering and concomitant anti-platelet effects. The microsomal cytochrome P-450 system comprises a superfamily of proteins present in hepatic and extrahepatic tissues that is responsible for the metabolism of many drugs. The present study was undertaken to investigate the effects of D-003 on in vivo drug-metabolizing hepatic enzymes. Two experimental series (n = 6 animals/group) were performed. In the first series rats were randomly distributed in one control and two groups treated with D-003 at 1,000 and 2,000 mg/kg for 14 days. In the second one they were distributed in one control and three groups treated with D-003 (250, 500, and 1,000 mg/kg) for 6 months. All treatments were orally administered by gastric gavage. Control rats were orally treated only with acacia gum/water vehicle. The content of microsomal P-450, b (5) cytochromes, total sulfhydryl groups, nonprotein sulfhydryl groups, and protein-bound sulfhydryl groups as well as the activities of NADPH cytochrome c reductase, aminopyrine demethylase, dimethylnitrosamine N-demethylase, 7-ethoxyresorufin O-deethylation, 7-pentoxyresorufin O-depentylation, and cytosolic glutathione S-transferase were assessed. D-003 administered up to 2,000 mg/kg or 1,000 mg/kg during 14 days or 6 months did not affect the activities of the hepatic drug-metabolizing enzymes investigated. It is concluded that D-003 is not metabolized by the liver cytochrome system and that potential risk derived from drug-to-drug interactions between D-003 and concomitant drugs appears to be low.

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Dose-dependent cholesterol-lowering effects of D-003 on normocholesterolemic rabbits

Cited by 11 publications

References 16 publications

Identification of very long chain fatty acids from sugar cane wax by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy

Identification of very long chain fatty acids from sugar cane wax by atmospheric pressure chemical ionization liquid chromatography–mass spectroscopy

D-003 (Saccharum officinarum): The forgotten lipid-lowering agent

Effects of D-003 on Hepatic Drug-Metabolizing Enzyme Activities in Rats

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