There are various dental pathologies related to oral dysbiosis, where an overpopulation of pathogenic microorganisms is revealed, capable of triggering diseases that endanger the oral health of individuals who suffer from it, such as Gingivitis and Periodontitis. In the present work, an experimental study was carried out in the period between the months of September 2020 and June 2021. A toothpaste gel with medicinal properties was formulated from Aloe Vera L., in which, once the gel was obtained of said product, its compatibility with the other components of the formulation was evaluated and subsequently its physicochemical and microbiological stability was determined for a period of sixty days. We worked with 3 batches and 3 replicates. Sampling for trials was always random and variance between samples was determined for each trial. The results showed that the Aloe Vera L. gel obtained is compatible with the other components of the formulation and that it meets the requirements of physicochemical and microbiological stability over the time studied according to Cuban standards for the development of natural products.