Dorsomedial striatal contributions to different forms of risk/reward decision making

Schumacher, Jackson D; Holstein, Mieke van; Bagrodia, Vaishali; Bouder, Hannah B. Le; Floresco, Stan B.

doi:10.1016/j.nlm.2020.107369

Cited by 11 publications

(12 citation statements)

References 56 publications

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“…100%; ascending variant). This was done to delineate whether an increase in risky choice observed in the descending condition reflected either a general increase in preference for larger uncertain rewards (as has been observed after mOFC inactivation or an impairment in adjusting decision biases as has been reported following inactivation of the prelimbic prefrontal cortex (PFC), and DMS (St. Onge and Floresco, 2010;Schumacher et al, 2021). In the latter case, one would expect to see reduced preference for the risky options in the ascending condition as blocks progressed.…”

Section: Methodsmentioning

confidence: 99%

“…In comparison, it is well documented that the dorsomedial striatum (DMS) promotes goaldirected action (Yin et al, 2005(Yin et al, , 2008 and cognitive flexibility (Ragozzino et al, 2002;Ragozzino, 2007;Castañé et al, 2010;Grospe et al, 2018). Interestingly, there are few studies examining the contribution of the DMS to cost/benefit decision-making, yet we have recently identified a role for this striatal compartment in facilitating flexible shifts in choice biases during probabilistic discounting (Schumacher et al, 2021).…”

Section: Introductionmentioning

confidence: 92%

“…Furthermore, the near-random patterns of risk/reward decision-making induced by disconnection of this circuit may reflect a disruption in processes involved in appraising the relative incentive value of the larger versus smaller rewards when these rewards are uncertain. mOFC fi DMS in risk/reward decision-making We have recently characterized a role for the DMS in facilitating adjustments in decision biases during probabilistic discounting (Schumacher et al, 2021). Here, we sought to determine whether the ability of the DMS to facilitate shifts in decision biases was dependent on input from the mOFC.…”

Section: Reward Magnitude Discriminationmentioning

confidence: 99%

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Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making

2022

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The medial orbitofrontal cortex (mOFC) regulates a variety of cognitive functions, including refining action selection involving reward uncertainty. This region sends projections to numerous subcortical targets, including the ventral and dorsal striatum, yet how these corticostriatal circuits differentially regulate risk/reward decision-making is unknown. The present study examined the contribution of mOFC circuits linking the nucleus accumbens (NAc) and dorsomedial striatum (DMS) to risk/ reward decision-making using pharmacological disconnections. Male rats were well trained on a probabilistic discounting task involving choice between small/certain or large/risky rewards, with the probability of obtaining the larger reward decreasing or increasing over a session. Disconnection of mOFC-striatal pathways was achieved using infusions of GABA agonists inactivating the mOFC in one hemisphere, combined with NAc or DMS inactivation in the contralateral or ipsilateral hemisphere. Perturbing mOFC fi NAc circuits induced suboptimal, near-random patterns of choice that manifested as a flattening of the discounting curve. Animals were equally likely to stay or shift following rewarded/nonrewarded choices, suggesting this pathway mediates use of information about reward history to stabilize decision biases. In contrast, mOFC fi DMS disconnection impaired adjustments in decision biases, causing opposing changes in risky choice depending on how probabilities varied over time. This was driven by alterations in lose-shift behavior, suggesting mOFC fi DMS circuits track volatility in nonrewarded actions to adjust choice in accordance with changes in profitability. Thus, separate mOFC-striatal projection pathways regulate dissociable processes underlying decision-making, with mOFC fi NAc circuits aiding in establishing and stabilizing tasks states and mOFC fi DMS circuits facilitating transitions across states to promote flexible reward seeking.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Reward Magnitude Discriminationmentioning

confidence: 99%

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Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making

2022

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“…Further, individual differences in the extent to which alcohol seeking engages activity in the DLS predicts susceptibility to punishment resistance ( Giuliano et al, 2019 ), suggesting a specific role in compulsivity and threat-based feedback. DMS inactivation increases risky choice on a probabilistic discounting task in rats, suggesting that it in contrast can facilitate flexibility in reward prediction ( Schumacher et al, 2021 ). Taken together, these results are consistent with the notion that SNc-DLS DA projections contribute to inflexible behavior, the SNc-DMS projections promote flexibility in goal-directed behavior, both of which are engaged during risk-reward decisions ( Lerner et al, 2015 ; Vandaele and Ahmed, 2021 ).…”

Section: Category III – Risky Substance Usementioning

confidence: 99%

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Poisson

Engel

Saunders

2021

Front. Neural Circuits

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Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have been made to model features of these criteria in non-human animal research subjects, for insight into the underlying neurobiological mechanisms. Here we review evidence from rodent models of SUD-inspired criteria, focusing on the role of the striatal dopamine system. We identify distinct mesostriatal and nigrostriatal dopamine circuit functions in behavioral outcomes that are relevant to addictions and SUDs. This work suggests that striatal dopamine is essential for not only positive symptom features of SUDs, such as elevated intake and craving, but also for impairments in decision making that underlie compulsive behavior, reduced sociality, and risk taking. Understanding the functional heterogeneity of the dopamine system and related networks can offer insight into this complex symptomatology and may lead to more targeted treatments.

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“…As simulated in human behavior paradigms, risky decision-making scenarios in life are often guided by external cues that inform the likelihood of receiving certain rewards ( Garofalo et al, 2020 ). Studies have shown that the manner in which brain circuitry contributes to guiding choice under cue-generated conditions may differ from those where decisions are guided by internally-generated information ( Floresco et al, 2018 ; van Holstein et al, 2020 ; Schumacher et al, 2021 ). However, due to the relative paucity of animal behavioral paradigms, there are few studies on the neural basis of risky decision-making behavior guided by external cues ( Floresco et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats

Yang

et al. 2022

Front. Behav. Neurosci.

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Risky decision-making is the decision made by individuals when they know the probability of each outcome. In order to survive in unpredictable environments, it is necessary for individuals to assess the probability of events occurring to an make appropriate decisions. There are few studies on the neural basis of risky decision-making behavior guided by external cues, which is related to the relative paucity of animal behavioral paradigms. Previous studies have shown that the prefrontal cortex (PFC) plays a key role in risk-based decision-making. The PFC receives projections from the dopamine (DA) system from the ventral tegmental area of the midbrain. The mesocorticolimbic DA system regulates the judgments of reward and value in decision-making. However, the specific receptor mechanism for prefrontal DA regulation of cue-guided risky decision-making behavior remains unclear. Here we established a cue-guided risky decision-making behavioral paradigm (RDM task) to detect the behavior of rats making decisions between a small certain reward and a large uncertain reward in a self-paced manner. The D1 receptor antagonist SCH-23390 (5 mM) or agonist SKF-82958 (5 mM), and the D2 receptor antagonist thioridazine hydrochloride (5 mM) or agonist MLS-1547 (5 mM) was injected into the mPFC, respectively, to investigate how the behavior in the RDM task was changed. The results showed that: (1) rats were able to master the operation of the cue-guided RDM task in a self-paced way; (2) a majority of rats were inclined to choose risk rather than a safe option when the reward expectations were equal; and (3) risk selection was reduced upon inhibition of D1 receptors or stimulation of D2 receptors, but increased upon stimulation of D1 receptors or inhibition of D2 receptors, suggesting that the RDM performance is regulated by D1 and D2 receptors in the mPFC. The present results suggest that DA receptors in the mPFC of rats are involved in regulating cue-guided RDM behavior, with differential involvement of D1 and D2 receptors in the regulation.

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Dorsomedial striatal contributions to different forms of risk/reward decision making

Cited by 11 publications

References 56 publications

Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making

Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats

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