Dorsolateral prefrontal contributions to human working memory

Barbey, Aron K.; Koenigs, Michael; Grafman, Jordan

doi:10.1016/j.cortex.2012.05.022

Cited by 696 publications

(471 citation statements)

References 65 publications

(96 reference statements)

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“…To the degree that vast portions of the frontal cortex can contribute topdown maintenance signals, along with other "sources," such as the parietal cortex and hippocampus (Fuster 2013), one might predict that restricted frontal lesions will not profoundly impair the performance on simple maintenance tasks, such as digit-span forward. This prediction is supported by the results from human lesion studies showing that frontal lesions have weak or no negative effects on simple workingmemory maintenance (e.g., Volle et al 2008;Barbey et al 2013). In contrast, frontal lesions, notably in the dorsolateral cortex, have marked impact on working-memory manipulation operations, and functional imaging studies have shown elevated dorsolateral prefrontal activity as a function of the complexity of workingmemory operations (e.g., Nagel et al 2009;Nyberg et al 2009b).…”

Section: How Can Information In Working Memory Be Manipulated and Updmentioning

confidence: 63%

Working Memory: Maintenance, Updating, and the Realization of Intentions

Nyberg

Eriksson

2015

Cold Spring Harb Perspect Biol

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Correspondence: lars.nyberg@umu.se "Working memory" refers to a vast set of mnemonic processes and associated brain networks, relates to basic intellectual abilities, and underlies many real-world functions. Workingmemory maintenance involves frontoparietal regions and distributed representational areas, and can be based on persistent activity in reentrant loops, synchronous oscillations, or changes in synaptic strength. Manipulation of content of working memory depends on the dorsofrontal cortex, and updating is realized by a frontostriatal '"gating" function. Goals and intentions are represented as cognitive and motivational contexts in the rostrofrontal cortex. Different working-memory networks are linked via associative reinforcement-learning mechanisms into a self-organizing system. Normal capacity variation, as well as workingmemory deficits, can largely be accounted for by the effectiveness and integrity of the basal ganglia and dopaminergic neurotransmission.

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Section: How Can Information In Working Memory Be Manipulated and Updmentioning

confidence: 63%

Working Memory: Maintenance, Updating, and the Realization of Intentions

Nyberg

Eriksson

2015

Cold Spring Harb Perspect Biol

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“…Future studies that examine how brain activation changes pretreatment to posttreatment are needed to address these questions. It should also be noted that lateral PFC is involved in a range of executive functions (Tanji and Hoshi, 2008), and dlPFC is essential for manipulating information in working memory (Barbey et al, 2013). Thus it is possible that greater lateral PFC activation in the current study corresponds with greater attentional control or ability to maintain the goal of face matching in the presence of threat.…”

Section: Discussionmentioning

confidence: 74%

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Kujawa

Swain

Hanna

et al. 2015

Neuropsychopharmacol

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Neuroimaging has shown promise as a tool to predict likelihood of treatment response in adult anxiety disorders, with potential implications for clinical decision-making. Despite the relatively high prevalence and emergence of anxiety disorders in youth, very little work has evaluated neural predictors of response to treatment. The goal of the current study was to examine brain function during emotional face processing as a predictor of response to treatment in children and adolescents (age 7-19 years; N = 41) with generalized, social, and/ or separation anxiety disorder. Prior to beginning treatment with the selective serotonin reuptake inhibitor (SSRI) sertraline or cognitive behavior therapy (CBT), participants completed an emotional faces matching task during functional magnetic resonance imaging (fMRI). Whole brain responses to threatening (ie, angry and fearful) and happy faces were examined as predictors of change in anxiety severity following treatment. Greater activation in inferior and superior frontal gyri, including dorsolateral prefrontal cortex and ventrolateral prefrontal cortex, as well as precentral/postcentral gyri during processing of threatening faces predicted greater response to CBT and SSRI treatment. For processing of happy faces, activation in postcentral gyrus was a significant predictor of treatment response. Post-hoc analyses indicated that effects were not significantly moderated by type of treatment. Findings suggest that greater activation in prefrontal regions involved in appraising and regulating responses to social signals of threat predict better response to SSRI and CBT treatment in anxious youth and that neuroimaging may be a useful tool for predicting how youth will respond to treatment.

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“…Patients with selective hippocampal damage show impairments during performance of the RAM that are comparable to animals with HC lesions (Goodrich-Hunsaker and Hopkins, 2010). Although the effect of DLPFC lesions on RAM performance in humans is unknown, there is sound evidence that such lesions lead to impaired cognitive control (Gläscher et al, 2012) and deficient executive processes during WM (Barbey et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal–Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study

Bähner

Demanuele

Schweiger

et al. 2015

Neuropsychopharmacol

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Hippocampal-prefrontal cortex (HC-PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting and translation of findings is complicated by the use of differing paradigms across species. We therefore used functional magnetic resonance imaging together with a spatial WM paradigm adapted from rodent research to examine HC-PFC coupling in humans. A PFC-parietal network was functionally connected to hippocampus (HC) during task stages requiring high levels of executive control but not during a matched control condition. The magnitude of coupling in a network comprising HC, bilateral dorsolateral PFC (DLPFC), and right supramarginal gyrus explained one-fourth of the variability in an independent spatial WM task but was unrelated to visual WM performance. HC-DLPFC coupling may thus represent a systems-level mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling cognitive dysfunction in translational neuroscience.

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Dorsolateral prefrontal contributions to human working memory

Cited by 696 publications

References 65 publications

Working Memory: Maintenance, Updating, and the Realization of Intentions

Working Memory: Maintenance, Updating, and the Realization of Intentions

Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth

Hippocampal–Dorsolateral Prefrontal Coupling as a Species-Conserved Cognitive Mechanism: A Human Translational Imaging Study

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