Dorsal and ventral language pathways in persistent developmental stuttering

Kronfeld-Duenias, Vered; Amir, Ofer; Ezrati-Vinacour, Ruth; Civier, Oren; Ben-Shachar, Michal

doi:10.1016/j.cortex.2016.04.001

Cited by 43 publications

(27 citation statements)

References 85 publications

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“…There is still, though, a lack of consensus on the fiber pathway systems associated with stuttering (Ingham, Ingham, Euler, & Neumann, 2017;Kronfeld-Duenias, Amir, Ezrati-Vinacour, Civier, & Ben-Shachar, 2016aNeef, Anwander, & Friederici, 2017). Structural differences are reported in the white matter underneath the IFG, angular gyrus, premotor cortex, and middle frontal gyrus (Chang, Zhu, Choo, & Angstadt, 2015;Connally, Ward, Howell, & Watkins, 2014;Watkins et al, 2008), and in the anterior segment of the right arcuate fasciculus (Kronfeld-Duenias et al, 2016a). Three recent studies, however, have specifically focused on the involvement of the FAT in persistent developmental stuttering.…”

Section: Functional Associations Of the Left Frontal Aslant Tract In mentioning

confidence: 99%

The frontal aslant tract (FAT) and its role in speech, language and executive function

Dick

Garic

Graziano

et al. 2018

Preprint

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In this review, we examine the structural connectivity of a recently-identified fiber pathway, the frontal aslant tract (FAT), and explore its function. We first review structural connectivity studies using tract-tracing methods in non-human primates, and diffusion-weighted imaging and electrotimulation in humans. These studies suggest a monosynaptic connection exists between the lateral inferior frontal gyrus and the pre-supplementary and supplementary motor areas of the medial superior frontal gyrus. This connection is termed the FAT. We then review research on the left FAT's putative role in supporting speech and language function, with particular focus on speech initiation, stuttering, verbal fluency and language more broadly. Next, we review research on the right FAT's putative role supporting executive function, namely inhibitory control and conflict monitoring. We summarize the extant body of empirical work by suggesting that the FAT plays a domain general role in the planning, timing, and coordination of sequential motor movements, and in the resolution of competition among possible cognitive and motor plans. However, we also propose some domain specialization across the hemispheres. On the left hemisphere, the circuit is proposed to be specialized for speech actions. On the right hemisphere, the circuit is proposed to be specialized for general action control of the organism, especially in the visuo-spatial domain. We close the review with a discussion of the clinical significance of the FAT, and suggestions for further research on the pathway.

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Section: Functional Associations Of the Left Frontal Aslant Tract In mentioning

confidence: 99%

The frontal aslant tract (FAT) and its role in speech, language and executive function

Dick

Garic

Graziano

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…Diffusion-weighted MRI quantifies properties of white matter structures and, thus, helps to scrutinize structural connectivity. In the context of stuttering, a number of diffusion-weighted MRI studies report a reduced fractional anisotropy in speech-related fibre pathways, such as the left superior longitudinal fasciculus (SLF; Sommer et al , 2002 ; Chang et al , 2008 ; Watkins et al , 2008 ; Kell et al , 2009 ; Cykowski et al , 2010 ; Cai et al , 2014 a ; Kronfeld-Duenias et al , 2016 b ), a prominent dorsal fibre pathway that includes the arcuate fasciculus ( Makris et al , 2005 ) and that connects fronto-parieto-temporal regions ( Catani et al , 2005 ) of the speech network ( Hickok and Poeppel, 2007 ). More recently, structural differences were also shown in the left frontal aslant tract (FAT; Kronfeld-Duenias et al , 2016 a ), a fibre pathway that connects the posterior region of the IFG with the SMA and pre-SMA ( Catani et al , 2012 ), relevant for fluent speech production ( Guenther, 2016 ; Kemerdere et al , 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…Reports on right hemisphere white matter differences are less robust ( Cai et al , 2014 a ; Neef et al , 2015 ). For the frontal lobe, structural differences are reported in the white matter underneath the IFG, premotor cortex, and middle frontal gyrus (MFG; Watkins et al , 2008 ; Connally et al , 2014 ; Chang et al , 2015 ), in the anterior segment of the right anterior fasciculus ( Kronfeld-Duenias et al , 2016 b ), and in the right FAT ( Kronfeld-Duenias et al , 2016 a ).…”

Section: Introductionmentioning

confidence: 99%

Structural connectivity of right frontal hyperactive areas scales with stuttering severity

Neef

Anwander

Bütfering

et al. 2017

Brain

106

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“…Accordingly, case studies provide additional valuable insights into the complex neural architecture of stuttering (Ingham et al 2012 ; Wymbs et al 2013 ). Diffusion magnetic resonance imaging (dMRI) repeatedly provided evidence for less coherent white matter structures (Sommer et al 2002 ; Chang et al 2008 , 2015 ; Watkins et al 2008 ; Kell et al 2009 ; Cykowski et al 2010 ; Kronfeld-Duenias et al 2014 , 2016 ). Affected connections might impede the signal transfer between language-related and speech-related left fronto-parieto-temporal brain regions as summarized in a recent quantitative review (Neef et al 2015a ).…”

Section: Introductionmentioning

confidence: 99%

Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering

et al. 2017

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Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-017-1476-1) contains supplementary material, which is available to authorized users.

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Dorsal and ventral language pathways in persistent developmental stuttering

Cited by 43 publications

References 85 publications

The frontal aslant tract (FAT) and its role in speech, language and executive function

The frontal aslant tract (FAT) and its role in speech, language and executive function

Structural connectivity of right frontal hyperactive areas scales with stuttering severity

Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering

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