Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering

Metzger, Friederike Luise; Auer, Tibor; Helms, Gunther; Paulus, Walter; Frahm, Jens; Sommer, Martin; Neef, Nicole E.

doi:10.1007/s00429-017-1476-1

Cited by 27 publications

(39 citation statements)

References 135 publications

(171 reference statements)

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“…Generally, there seems to be a renewed interest over the past few years in studying anticipation as a critical component of stuttering and the stuttering experience in AWS. [14][15][16][17] There is limited evidence of anticipation in CWS. Early work showed that 45% of 10-to 11year-olds and 38% of 8-to 9-year-olds reported anticipating "sometimes," 18 suggesting that as a group, CWS also anticipate stuttering but less so than AWS.…”

Section: How Often Do People Who Stutter Anticipate Stuttering?mentioning

confidence: 99%

My Client Knows That He's About to Stutter: How Can We Address Stuttering Anticipation during Therapy with Young People Who Stutter?

et al. 2018

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Stuttering anticipation is endorsed by many people who stutter as a core aspect of the stuttering experience. Anticipation is primarily a covert phenomenon and people who stutter respond to anticipation in a variety of ways. At the same time as anticipation occurs and develops internally, for many individuals the "knowing" or "feeling" that they are about to stutter is a primary contributor to the chronicity of the disorder. In this article, we offer a roadmap for both understanding the phenomenon of anticipation and its relevance to stuttering development. We introduce the (SAS)-a 25-item clinical tool that can be used to explore a client's internal experience of anticipation to drive goal development and clinical decision making. We ground this discussion in a hypothetical case study of "Ryan," a 14-year-old who stutters, to demonstrate how clinicians might use the SAS to address anticipation in therapy with young people who stutter.

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Section: How Often Do People Who Stutter Anticipate Stuttering?mentioning

confidence: 99%

My Client Knows That He's About to Stutter: How Can We Address Stuttering Anticipation during Therapy with Young People Who Stutter?

et al. 2018

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“…Approximately 5% of children suffer from stuttering. There is no consensus regarding the pathophysiology of stuttering, but it is thought to be related to a deregulation of the dopaminergic state, with an increase in dopaminergic activity in the brain that can be visualized by positron emission tomography . The involvement of dopaminergic system dysregulation has been confirmed by studies of developmental stuttering in patients with Parkinson's disease and receiving dopaminergic treatment .…”

Section: Discussionmentioning

confidence: 99%

“…Data regarding the prevalence of ADHD are highly variable, but a meta‐analysis of 175 studies by Thomas et al reported an overall pooled estimate of 7.2% (95% confidence interval [CI] 6.7–7.8) . Stuttering is a common speech disorder that affects about 5% of children . Data concerning the combination of stuttering and MPH are contradictory.…”

Section: Introductionmentioning

confidence: 99%

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Methylphenidate and stuttering

Trenque

Claustre

Herlem

et al. 2019

Brit J Clinical Pharma

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Methylphenidate (MPH) is a piperidine similar to amphetamines, and is indicated for attention deficit hyperactivity disorder. Studies concerning stuttering occurring with MPH are contradictory. We investigated the association between MPH and stuttering. We analysed reports in the World Health Organization global individual case safety reports database, Vigibase, up to 31 December 2018, with the MedDRA preferred term “dysphemia” and the lower level terms “stutter” and “stuttering”. The association between exposure to MPH and occurrence of the adverse drug reaction was estimated by disproportionality analysis. Reporting odds ratios (RORs) were calculated with 95% confidence intervals (CIs). In total, 2975 cases of dysphemia were reported, of which 46 reports were associated with MPH. For the Preferred Term “dysphemia”, the ROR was 7.3 (95% CI: 5.4–9.8). With the Lower Level Term “stuttering”, 584 cases were registered in the database of which 17 involved MPH. The ROR was 13.9 (95% CI: 8.6–22.5). This study found a signal for stuttering with MPH.

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“…The right inferior frontal cortex is also a key node in the network of brain areas involved in response inhibition (Aron, Robbins, & Poldrack, 2004;Chambers et al, 2007;Xue, Aron, & Poldrack, 2008). It is hypothesized that differences in inhibitory control may account, in part, for brain differences described in developmental stuttering (Alm, 2004;Hartwigsen, Neef, Camilleri, Margulies, & Eickhoff, 2019;Metzger et al, 2018;Neef et al, 2018Neef et al, , 2015Xue et al, 2008). Here, a classic inhibition task was used with PWS whilst recording functional MRI images to test whether there are differences in the neural control of inhibition.…”

Section: Introductionmentioning

confidence: 99%

An fMRI study of initiation and inhibition of manual responses in people who stutter

Wiltshire¹,

Chesters²,

Krishnan³

et al. 2020

Preprint

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Developmental stuttering is a speech motor disorder characterised by difficulties initiating speech and frequent interruptions to the speech flow. Previous work suggests that people who stutter (PWS) have an overactive response suppression mechanism. Imaging studies of speech production in PWS consistently reveal greater activity of the right inferior frontal cortex, an area robustly implicated in inhibitory control of both manual and spoken responses. Here, we used a manual response version of the stop-signal task during fMRI to investigate neural differences related to response initiation and inhibition in PWS. Behaviourally, PWS were slower to respond to 'go' stimuli than people who are typically fluent (PWTF), but there was no difference in stop-signal reaction time. Our fMRI results were consistent with these behavioural results. The fMRI analysis revealed the expected networks associated with manual response initiation and inhibition in both groups. However, all contrasts between the two groups were characterised by overactivity in PWS relative to PWTF. This overactivity was significantly different for the initiation of responses (i.e. the 'go' trials) but not for response inhibition (i.e. the 'stop' trials). One explanation of these results is that PWS are consistently in a heightened inhibition state, i.e. areas of the inhibition network are more active, generally. This interpretation is consistent with predictions from the global response suppression hypothesis.

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Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering

Cited by 27 publications

References 135 publications

My Client Knows That He's About to Stutter: How Can We Address Stuttering Anticipation during Therapy with Young People Who Stutter?

My Client Knows That He's About to Stutter: How Can We Address Stuttering Anticipation during Therapy with Young People Who Stutter?

Methylphenidate and stuttering

An fMRI study of initiation and inhibition of manual responses in people who stutter

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