Dormant tumor cells in liver and brain

Noltenius, Catherine; Noltenius, H

doi:10.1016/s0344-0338(85)80191-6

Cited by 25 publications

(3 citation statements)

References 8 publications

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“…Therefore, both dormancy mechanisms and both switches bear consideration when devising therapeutic strategies. Since the vast majority of DTCs in bone marrow and other tissues are found in a state consistent with cellular dormancy 17, 25 , and because anti-angiogenic strategies to maintain population-level dormancy have been discussed thoroughly elsewhere 26, 27 , the focus of this Perspective is cellular dormancy. It is important to note here that although it is often assumed that late arising metastases originate from dormant DTCs, current evidence is circumstantial in nature.…”

Section: Tumor Cell Dormancy: a Singular Focusmentioning

confidence: 99%

Metastasis prevention by targeting the dormant niche

2015

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Despite considerable advancements that shattered previously held dogmas about the metastatic cascade, evolution of therapies to treat metastatic disease has not kept up. In this Opinion article, I argue that rather than waiting for metastases to emerge before initiating treatment, it would be more effective to target metastatic seeds before they sprout. Specifically, I advocate directing therapies towards the niches that harbor dormant disseminated tumor cells in order to render them susceptible to cytotoxic agents. Treatment sensitization achieved by disrupting reservoirs of leukemic stem cells and latent HIV argues that this approach, though unconventional, could succeed in improving patient survival by delaying or even preventing metastasis.

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Section: Tumor Cell Dormancy: a Singular Focusmentioning

confidence: 99%

Metastasis prevention by targeting the dormant niche

2015

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“…Melanoma, lung, and some sub-types of breast cancer have a high propensity for brain metastasis ( Cagney et al., 2017 ). Traditional autopsy studies and recent advances in cancer genomics have revealed that brain metastasis can occur in the early stage of cancer progression, and the fate of these disseminated cancer cells is strongly dependent on the interaction with brain microenvironment ( Brastianos et al., 2015 ; Ghajar, 2015 ; McAllister and Weinberg, 2014 ; Noltenius and Noltenius, 1985 ; Obenauf and Massague, 2015 ; Sosa et al., 2014 ). The brain microenvironment consists of specialized cell types such as neurons, astrocytes, oligodendrocytes, microglial cells, and brain capillary endothelial cells ( Quail and Joyce, 2017 ; Winkler, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells

et al. 2020

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Brain metastasis is an ineffective process, and many cancer cells enter into an indolent state following extravasation in the brain. Single cell RNA sequencing of melanoma brain metastases reveals that non-proliferating brain metastatic melanoma cells exhibit a pattern of gene expression associated with inhibition of DNA methyltransferase 1 (DNMT1). The brain microenvironment, specifically the combination of reactive astrocytes and mechanically soft surroundings, suppressed DNMT1 expression in various cancer types and caused cell cycle delay. Somewhat unexpectedly, we find that DNMT1 suppression not only induces cell cycle delay but also activates pro-survival signals in brain metastatic cancer cells, including L1CAM and CRYAB. Our results demonstrate that transcriptional changes triggered by DNMT1 suppression is a key step for cancer cells to survive in the brain microenvironment and that they also restrict cancer cell proliferation. The dual consequences of DNMT1 suppression can explain the persistence of indolent cancer cells in the brain microenvironment.

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“…The vast majority of cancer patients (> 90%) have resting-state (G0) tumor cells in the brain [ 66 ]; these dormant cancer cells may take years or even decades to awake and outgrow as clinically detectable BrMs [ 67 ]. Both entering and exiting a dormant state require a permissive milieu, and identification of mechanisms responsible for these events poses a great challenge for scientists.…”

Section: Ecm Molecules In Control Of Brm Dormancymentioning

confidence: 99%

Critical functions of extracellular matrix in brain metastasis seeding

Yuzhalin,

2023

Cell. Mol. Life Sci.

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Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood–brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis. Lastly, we consider the possibility of targeting ECM for brain metastasis management.

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Dormant tumor cells in liver and brain

Cited by 25 publications

References 8 publications

Metastasis prevention by targeting the dormant niche

Metastasis prevention by targeting the dormant niche

The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells

Critical functions of extracellular matrix in brain metastasis seeding

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