Doramectin — a potent novel endectocide

Goudie, A. C.; Evans, N. A.; Gration, K.A.F.; Bishop, B.F.; Gibson, S.P.; Holdom, Kelvin S.; Kaye, B.; Wicks, S.R.; Lewis, David H.; Weatherley, Anthony; Bruce, Clinton; Herbert, Andrea; Seymour, D.J.

doi:10.1016/0304-4017(93)90218-c

Cited by 140 publications

(57 citation statements)

References 9 publications

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“…Many new avermectins have been synthesised to improve both the anti-parasitic efficacy and to change their pharmacokinetic profiles. Doramectin was biosynthesised from mutant S. avermitilis with a cyclohexyl group at the 25 position [3]. These three avermectins contain only C, H and O atoms (Fig.…”

Section: Introductionmentioning

confidence: 99%

Positive and negative electrospray LC–MS–MS methods for quantitation of the antiparasitic endectocide drugs, abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin and selamectin in milk

Durden

2007

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Positive and negative electrospray LC–MS–MS methods for quantitation of the antiparasitic endectocide drugs, abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin and selamectin in milk

Durden

2007

Journal of Chromatography B

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“…Doramectin diers from abamectin in the presence of a cyclohexyl group at the C25 position, and provides a similar spectrum of activity (Goudie et al 1993). Milbemycins, which only became commercially available 8 years after the ®rst commercial ivermectin product, dier structurally from the avermectins in that they lack the C13 oleandrose disaccharide (Takiguchi et al 1980).…”

Section: Introductionmentioning

confidence: 99%

Eprinomectin in dairy goats: dose influence on plasma levels and excretion in milk

Dupuy¹,

Chartier²,

Sutra³

et al. 2001

Parasitol Res

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The plasma levels and milk excretion of eprinomectin were determined in goats following topical application at doses of 0.5 mg kg(-1) and 1.0 mg kg(-1). The area under the concentration-time curve (AUC) was 2 times lower for 0.5 mg kg(-1) (8.24 +/- 3.50 ng day(-1) ml(-1)) than for 1.0 mg kg(-1) (15.68 +/- 8.84 ng day(-1) ml(-1)), suggesting that the pharmacokinetics of eprinomectin in goats is dose independent. The bioavailability of eprinomectin in lactating compared with non-lactating goats is low. This is probably due to the physiological status of dairy animals, which present a marked decrease in body fat. Comparison of the eprinomectin concentrations in the milk and plasma demonstrated a parallel disposition of the drug with a milk-to-plasma ratio of 0.10-0.25. The amount of drug recovered in the milk was 0.3-0.5% of the total administered dose. In all cases, the maximum level of residue in milk remained below the maximum acceptable level of 30 ng ml(-1) permitted in lactating cattle.

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“…Doramectin, a novel avermectin produced by fermentation of Streptomyces avermitilis, has a wide anthelmintic and ectoparasiticidal spectrum of activity [2]. A single injection of doramectin has shown to be highly efficacious against endo-and ecto-parasites of cattle [3,4,8] and swine [1].…”

mentioning

confidence: 99%

Efficacy of Doramectin against Intestinal Nematodes and Sarcoptic Mange Mites in Naturally Infected Swine.

Saeki

Fujii

Fukumoto

et al. 1997

The Journal of Veterinary Medical Science

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ABSTRACT. Endectocidal efficacy of doramectin administered intramuscularly at a dosage of 300 µg/kg was evaluated in 464 pigs naturally infected with intestinal nematodes or mange mites on 14 commercial farms in Japan. By doramectin treatment, fecal egg counts were reduced >99% for Ascaris suum, Strongyloides ransomi, Oesophagostomum dentatum, and For the trials against intestinal nematodes, fecal samples were collected from each animal immediately before treatment and on Days 7, 14 and 21 following treatment. Eggs in approximately 0.9 g fecal sample were enumerated using sugar centrifugal-flotation technique. According to the fecal egg counts derived before treatment, nine pigs with highest fecal egg counts were selected from each group for worm burden determination in Trial F. Then, surviving pigs among the pre-selected ones (9 from doramectin-treated and 8 from non-medicated control groups) were sacrificed on Day 21 following treatment.For the trials against sarcoptic mange, skin scrapings were collected from each animal immediately before treatment and on Days 7, 14, 21 and 28 following treatment. The skin scrapings were taken from an area of approximately 2 cm × 2 cm of mange lesion or the inner surface of an ear if no lesions were evident. The samples were digested in 10% NaOH overnight, then mites including adults, nymphs and larvae, and mite eggs were counted under the microscope. On the same days when scrapings were collected, the severity of skin lesion and pruritus were scored from 0 to 3, and from 0 to 2, respectively, using the score index as follows -(1) for skin lesion: 0=no active lesions, 1=no hyperkeratotic mange lesion, but slight lesions of encrustation, scaling or erythema, 2=a few localized moderately thick dry grayish-white crusty lesions, 3=large, thick, grayish, rough and dry crusts with coalescence of lesions, (2) for pruritus: 0=no scratching and rubbing, 1=low frequency of scratching and rubbing, 2=high frequency of scratching and rubbing.During the study period, control and treated groups were accommodated in separate pens on concrete floors in all trials except Trial H in which control and treated groups shared a single room with fermented sawdust litter.Fecal egg counts of A. suum, O. dentatum, T. suis, and of S. ransomi in the doramectin-treated groups decreased

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Doramectin — a potent novel endectocide

Cited by 140 publications

References 9 publications

Positive and negative electrospray LC–MS–MS methods for quantitation of the antiparasitic endectocide drugs, abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin and selamectin in milk

Positive and negative electrospray LC–MS–MS methods for quantitation of the antiparasitic endectocide drugs, abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin and selamectin in milk

Eprinomectin in dairy goats: dose influence on plasma levels and excretion in milk

Efficacy of Doramectin against Intestinal Nematodes and Sarcoptic Mange Mites in Naturally Infected Swine.

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