Doppler sonography of ocular and carotid arteries in Behçet patients

Akcar, Nevbahar; Göktekin, Feyza; Özer, Ahmet; Korkmaz, Cengiz

doi:10.1002/jcu.20725

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…[7][8][9] Alan et al [8] also proved the existence of decreased arterial distensibility in BD, and Rhee et al [22] detected increased arterial stiffness in BD. Akçar et al [26] reported lower peak systolic and end-diastolic flow velocities throughout internal carotid artery. Oflaz et al, [9] Chambers et al, [21] and Ulusoy et al [25] detected a decrease in the FMD values in BD.…”

Section: Discussionmentioning

confidence: 95%

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An Assessment of Flow-Mediated Dilatation in Behçet’s Disease

et al. 2012

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Amaç: Bu çalışmada Behçet hastasında erken ateroskleroz gelişimi, Doppler ultrasonografisi (US) eşliğinde girişimsel olmayan akım aracılı dilatasyon (FMD) yöntemi ile değerlendirildi. Hastalar ve yöntemler:Otuz Behçet hastası ve 25 sağlıklı gönüllü çalışmaya dahil edildi. Brakiyal arterde bazal ve reaktif hiperemi sonrası arter çapları, akım hızları, rezistivite indeksleri ve akım miktarlarını göstermek amacıyla Doppler US kullanıldı. Akım aracılı dilatasyon, bazal ve reaktif hiperemi sonrası ölçülen brakiyal arter çapları farkının yüzdesi olarak tanımlandı. Bulgular:Behçet hastalığı grubunda ortalama FMD değeri (%10.8±12.7) kontrol grubundan (%26±18.6), anlamlı derecede düşük bulundu. Diğer parametreler açısından gruplar arasında istatistiksel anlamlı farklılık bulunamadı.Sonuç: Behçet hastalarında erken ateroskleroz gelişimini göstermek amacıyla Doppler US eşliğinde FMD değerlendirilmesi basit ve girişimsel olmayan etkili bir yöntemdir.Anahtar sözcükler: Behçet hastalığı; Doppler ultrasonografisi; akım aracılı dilatasyon. Objectives: This study aims to evaluate the early development of atherosclerosis in patients with Behçet's disease (BD) using flow-mediated dilatation (FMD) method under Doppler ultrasonography (US). Patients and methods:Thirty patients with BD and 25 healthy volunteers were included. Doppler US was used to measure the basal and post-reactive hyperemic diameters, peak systolic velocities, resistivity indices, and blood flow volumes of the brachial arteries. Flowmediated dilatation was defined as the percentage of difference between the post-reactive hyperemic and basal diameters. Results:The mean FMD value of the BD group (10.8±12.7%) was significantly lower compared to the control group (26±18.6%). No statistically significant difference in other parameters was found between the groups. Conclusion:Flow-mediated dilatation under Doppler US is simple and effective non-invasive method for predicting the early development of atherosclerosis in patients with BD.

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Section: Discussionmentioning

confidence: 95%

“…[8][9][10][21][22][23][24][25][26] Increased values of IMT with BD have been reported in some studies. [7][8][9] Alan et al [8] also proved the existence of decreased arterial distensibility in BD, and Rhee et al [22] detected increased arterial stiffness in BD.…”

Section: Discussionmentioning

confidence: 99%

An Assessment of Flow-Mediated Dilatation in Behçet’s Disease

et al. 2012

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“…We achieved high inter-reader reliability and good agreement with the gold-standard, which was the direct measurement of erosion in a 3D print of the erosion. References: [1] . ROC curve analysis identified ECLAM and SLAM scores as predictors of a GPS≥1 with an AUC of 0.825 (95%CI 0.0.686-0.964, p=0.01) and 0.740 (95%CI 0.483-0.998, p=0.07) respectively.…”

Section: Discussionmentioning

confidence: 99%

FRI0579 Dynamic Doppler Evaluation of the Hand and Digital Arteries in Patients with Behçet's Disease

Özcan

Akıncı

Kara³

et al. 2015

Ann Rheum Dis

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BackgroundThe pathological process in Behçet's disease (BD) is autoimmune vasculitis which may involve all types and sizes of vessels. Previous studies evaluated the changes in vascular flow of ocular/carotid arteries, superior/inferior mesenteric artery with Doppler ultrasonography (US) (1,2). On the other hand, although very few, involvement of the distal extremity arteries has been mentioned in BD (3).ObjectivesTo evaluate the blood flow parameters of hand arteries in patients with BD by using Doppler US and to determine whether the blood flow parameters correlated with any of the diseases characteristics.MethodsTwenty-seven (13 F, 14 M) consecutive BD patients and 27 age- and sex-matched healthy controls were included. Demographic and clinical characteristics of the subjects were recorded. Doppler measurements for radial and ulnar arteries (wrist level), and ulnar proper palmar artery (3rd finger distal interphalangeal joint level) were performed bilaterally (Fig. 1).ResultsMean age of the patients and controls were 35.6±9.2 years (range, 19-59). Patient and control groups were similar as regards body mass index (25.0±3.2 kg/m2 vs 24.5±2.7 kg/m2) and number of smokers (9 vs 11) (both p values >0.05). The diameter and flow volume of radial, ulnar, digital arteries were decreased and pulsatility index were increased in BD group (all p values <0.05). All Doppler values of patients' radial arteries were significantly different from the control group (all p values <0.05). The diameter, flow volume, peak systolic velocity and end-diastolic velocity were decreased, resistive index and pulsatility index were increased in the radial artery (all p values <0.05).Figure 1.Doppler sonogram shows resistive index (RI) measurement on the Doppler spectral gate of the radial artery. PS; peak systolic velocity, ES; end-diastolic velocity, PI; pulsatility index.ConclusionsOur results demonstrated that hand blood flow decreased in BD patients when compared to healthy controls and that the changes were more predominant in the radial artery. Further studies with larger sample sizes with different disease characteristics are warranted to explain the clinical relevance of these findings.ReferencesAkçar N, Göktekin F, Ozer A, Korkmaz C. Doppler sonography of ocular and carotid arteries in Behçet patients. J Clin Ultrasound 2010;38:486-492.Siğirci A, Senol M, Aydin E, et al. Doppler waveforms and blood flow parameters of the superior and inferior mesenteric arteries in patients having Behçet disease with and without gastrointestinal symptoms: preliminary data. J Ultrasound Med 2003;22:449-457.Onder M, Ozden MG, Aksakal AB, et al. Raynaud phenomenon and behçet disease: diagnosis with technetium Tc 99m methylenediphosphonate bone scan and treatment with continuous sympathetic block. Arch Dermatol 2002;138:698-699.Disclosure of InterestNone declared

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“…6 Ocular hemodynamic changes in BD were previously investigated. The most common parameters used in these studies were the blood flow of central retinal artery, ophthalmic artery, posterior ciliary artery, and central retinal vein assessed by Doppler ultrasonography.…”

Section: Ocular Immunology and Inflammationmentioning

confidence: 99%

“…4,5 It was suggested that monitoring hemodynamics may help differentiate active and inactive uveitis and contribute to the clinical follow-up of Behçet patients. 6 Dynamic contour tonometry (DCT, Swiss Microtechnology, a Ziemer Ophthalmic Systems Group Company) is a slit-lamp mounted contact tonometer, which provides noninvasive and direct intraocular pressure (IOP) measurement irrespective of the corneal thickness or corneal elasticity by using a transcorneal method. The DCT gathers 100 IOP readings per second over a 5-to 8-s period and therefore records dynamic IOP and measures ocular pulse amplitude (OPA), which is an indirect indicator of the choroidal perfusion and reflects the ocular blood flow corresponding to the heart pulse as a function of time.…”

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confidence: 99%