An Assessment of Flow-Mediated Dilatation in Behçet’s Disease

Abstract

Amaç: Bu çalışmada Behçet hastasında erken ateroskleroz gelişimi, Doppler ultrasonografisi (US) eşliğinde girişimsel olmayan akım aracılı dilatasyon (FMD) yöntemi ile değerlendirildi. Hastalar ve yöntemler:Otuz Behçet hastası ve 25 sağlıklı gönüllü çalışmaya dahil edildi. Brakiyal arterde bazal ve reaktif hiperemi sonrası arter çapları, akım hızları, rezistivite indeksleri ve akım miktarlarını göstermek amacıyla Doppler US kullanıldı. Akım aracılı dilatasyon, bazal ve reaktif hiperemi sonrası ölçülen brakiyal arter çapları farkının yüzdesi olarak tanımlandı. Bulgular:Behçet hastalığı grubunda ortalama FMD değeri (%10.8±12.7) kontrol grubundan (%26±18.6), anlamlı derecede düşük bulundu. Diğer parametreler açısından gruplar arasında istatistiksel anlamlı farklılık bulunamadı.Sonuç: Behçet hastalarında erken ateroskleroz gelişimini göstermek amacıyla Doppler US eşliğinde FMD değerlendirilmesi basit ve girişimsel olmayan etkili bir yöntemdir.Anahtar sözcükler: Behçet hastalığı; Doppler ultrasonografisi; akım aracılı dilatasyon. Objectives: This study aims to evaluate the early development of atherosclerosis in patients with Behçet's disease (BD) using flow-mediated dilatation (FMD) method under Doppler ultrasonography (US). Patients and methods:Thirty patients with BD and 25 healthy volunteers were included. Doppler US was used to measure the basal and post-reactive hyperemic diameters, peak systolic velocities, resistivity indices, and blood flow volumes of the brachial arteries. Flowmediated dilatation was defined as the percentage of difference between the post-reactive hyperemic and basal diameters. Results:The mean FMD value of the BD group (10.8±12.7%) was significantly lower compared to the control group (26±18.6%). No statistically significant difference in other parameters was found between the groups. Conclusion:Flow-mediated dilatation under Doppler US is simple and effective non-invasive method for predicting the early development of atherosclerosis in patients with BD.

Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

“…2B). Pooled data from inactive disease patients [20,22,23,25,26,[37][38][39] also revealed impaired FMD with moderate heterogeneity (SMD ¼ À0.74, 95% CI: À 0.97 to À 0.51, p ¼ 0.0001, I 2 ¼ 35.5%) (Fig. 2C).…”

“…1), 24 studies met the criteria for inclusion in the analysis: 9 investigated FMD and/or EMD [18][19][20][21][22][23][24][25][26], 11 IMT [8,[27][28][29][30][31][32][33][34][35][36] and 4 investigated both [37][38][39][40].…”

“…BD patients were then split according to active and inactive disease where possible: we arbitrarily considered patients with vascular involvement [20,37,38] as having active disease and pooled them with active disease patients proper [20,22,23,25,26,40]: FMD was significantly lower with moderate heterogeneity (SMD ¼ À1.17, 95% CI: À 1.45 to À 0.89, p ¼ 0.0001, I 2 ¼ 37.5%) (Fig. 2B).…”