Doppler Modes

Objective: Monitoring microcirculation and visualizing microvasculature are critical for providing diagnosis to medical professionals and guiding clinical interventions.Ultrasound provides a medium for monitoring and visualization; however, there are challenges due to the complex microscale geometry of the vasculature and difficulties associated with quantifying perfusion. Here, we studied established and state-of-theart ultrasonic modalities (using six probes) to compare their detection of slow flow in small microvasculature. Methods: Five ultrasonic modalities were studied: grayscale, color Doppler, power Doppler, superb microvascular imaging (SMI), and microflow imaging (MFI), using six linear probes across two ultrasound scanners. Image readability was blindly scored by radiologists and quantified for evaluation. Vasculature visualization was investigated both in vitro (resolution and flow characterization) and in vivo (fingertip microvasculature detection). Results: Superb Microvascular Imaging (SMI) and Micro Flow Imaging (MFI) modalities provided superior images when compared with conventional ultrasound imaging How to cite this article: Aghabaglou F, Ainechi A, Abramson H, et al. Ultrasound monitoring of microcirculation: An original study from the laboratory bench to the clinic.

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“…note the addition of the yellow color for PDI in the Canon scanner, when compared to Philips). 51 , 52 …”

Section: Resultsmentioning

confidence: 99%

Ultrasound monitoring of microcirculation: An original study from the laboratory bench to the clinic

et al. 2022

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“…9 10 Gutierrez et al found a significant correlation between power-Doppler findings, the extent of skin involvement and histopathological degree of vascularisation before and after Etanercept treatment, and they proved that colour- and power-Doppler examination can be also useful in monitoring the disease activity. Conventional Doppler has limitations in evaluating vessels <0.1 mm in diameter and visualising microvessels, 40 because they are normally coded as noise background, filtered and undetected. Colour-Doppler and power-Doppler, in fact, use traditional wall filters to suppress background motion artefacts.…”

Section: Discussionmentioning

confidence: 99%

Shear wave elastography and microvascular ultrasound in response evaluation to calcipotriol+betamethasone foam in plaque psoriasis

Guazzaroni

Ferrari

Lamacchia

et al. 2020

Postgraduate Medical Journal

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Psoriasis (PsO) is a chronic skin disease. This study aims to evaluate clinical and subclinical response to calcipotriol+betamethasone foam, in patients with PsO, comparing, for the first time, data from microvascular ultrasound (MicroV) and shear wave elastography (SWE) with Psoriasis Area and Severity Index (PASI).MethodsBetween November 2018 and April 2019 in Tor Vergata Hospital (Roma, Italy), we enrolled 26 patients with PsO who were ageds 20–75 years, with PASI score ≥4, candidated for calcipotriol+betamethasone foam treatment. They underwent MicroV and SWE evaluation at baseline (T0) and after 4 weeks of treatment (T4). Clinical follow-up was carried on at T4, T8 and T12. Student’s t-test (p values<0.05 statistically significant) was used to compare SWE and PASI values.ResultsAt T0, SWE stiffness values of target plaques (61.5% on elbows, 23% knees, 7.7% sacrum,7.7% legs) were significantly higher than values under healthy skin. At T4, all patients showed a significant reduction of PASI; MicroV showed reduction in vascularisation of responsive plaques in 85% of cases, only in 15%, the vascularisation degree remained stable; and SWE values of target plaques were significantly lower compared with T0. Only in 7.7%, there was a relapse at T12.ConclusionsCalcipotriol+betamethasone foam is a very effective topical treatment in a short-medium term follow-up in patients with PsO. MicroV and SWE evaluate response to treatment (in term of plaque vascularisation and stiffness), so they could represent promising early indicators of therapeutic response and help the physician to establish a better clinical-therapeutic management of patients with PsO.

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“…1C). The actual received signal needs to be demodulated before extracting Doppler signals (1,30). Relatively low-frequency Doppler signals from slowly moving vessel walls and muscular tissue will be eliminated from the output by applying a high-pass filter (1,31).…”

Section: Working Principle and Device Designmentioning

confidence: 99%

“…Alternatively, one middle transducer receives and two adjacent transducers transmit simultaneously to reinforce sound intensity for a larger depth of penetration. CW Doppler offers simple signal processing, easy operation, and an unlimited maximum measurable flow velocity compared with pulse-wave Doppler (further discussions are provided in note S2) (1,30). Flow velocities in small vessels like capillaries are very low, which have little impact on the monitoring of carotid, branchial, and other arteries.…”

Section: Working Principle and Device Designmentioning

confidence: 99%

Flexible Doppler ultrasound device for the monitoring of blood flow velocity

et al. 2021

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Thrombosis and restenosis after vascular reconstruction procedures may cause complications such as stroke, but a clinical means to continuously monitor vascular conditions is lacking. Conventional ultrasound probes are rigid, particularly for postoperative patients with fragile skin. Techniques based on photoplethysmography or thermal analysis provide only relative changes in flow volume and have a shallow detection depth. Here, we introduce a flexible Doppler ultrasound device for the continuous monitoring of the absolute velocity of blood flow in deeply embedded arteries based on the Doppler effect. The device is thin (1 mm), lightweight (0.75 g), and skin conforming. When the dual-beam Doppler method is used, the influence of the Doppler angle on the velocity measurement is avoided. Experimental studies on ultrasound phantoms and human subjects demonstrate accurate measurement of the flow velocity. The wearable Doppler device has the potential to enhance the quality of care of patients after reconstruction surgery.

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Doppler Modes

Cited by 7 publications

References 77 publications

Ultrasound monitoring of microcirculation: An original study from the laboratory bench to the clinic

Ultrasound monitoring of microcirculation: An original study from the laboratory bench to the clinic

Shear wave elastography and microvascular ultrasound in response evaluation to calcipotriol+betamethasone foam in plaque psoriasis

Flexible Doppler ultrasound device for the monitoring of blood flow velocity

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