Doped silica nanoparticles containing two-photon luminescent Eu(iii) complexes for the development of water stable bio-labels

Philippot, Cécile; Bourdolle, Adrien; Maury, Olivier; Dubois, Frédéric; Boury, Bruno; Brustlein, Sophie; Brasselet, Sophie; Andraud, Chantal; Ibanez, Alain

doi:10.1039/c1jm13551a

Cited by 20 publications

(15 citation statements)

References 78 publications

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“…Visually, the EDX elemental mapping confirms the presence of C/N/O/rare-earth metal inside the doped GQDs (Figure 2b-f; Figure S1b-f, Supporting Information) indicating that the GQD product has mostly a carbon structure with few nitrogen and oxygen functional groups enabling water solubility and light <1% rare-earth metal doping. Given the low doping percentages, it is plausible that the water contact known to quench rareearth metal fluorescence [41][42][43] is minimized for the dopants in the inner GQD regions, thus enabling the observed optical properties. The size difference for Tm-GQDs and Nd-GQDs is not expected to substantially affect their application performance based on our previous findings [9] showing no substantial alteration of NIR emission with GQD size alteration by microwave processing time increase.…”

Section: Resultsmentioning

confidence: 99%

Rare‐Earth Metal Ions Doped Graphene Quantum Dots for Near‐IR In Vitro/In Vivo/Ex Vivo Imaging Applications

Hasan

González-Rodríguez

Lin

et al. 2020

Advanced Optical Materials

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Near‐infrared (NIR) emitting biocompatible nanomaterials are desired in biotechnology as higher penetration depth fluorescence imaging probes. In this work, novel NIR‐emissive Nd3+‐doped or Tm3+‐doped biocompatible graphene quantum dots (GQDs) are developed via scalable, single‐step bottom‐up synthesis. Water‐soluble Nd‐GQDs/Tm‐GQDs with average diameters of 5.6–8.2 nm possess crystalline graphene lattice with <1 atomic percent of Nd/Tm and exhibit NIR fluorescence at ≈1060/≈925 nm attributed to the intrinsic transitions of Nd3+/Tm3+. High biocompatibility with >80% cell viability at 1 mg mL−1 for Nd‐GQDs and 0.25 mg mL−1 for Tm‐GQDs makes them well‐suited for bioimaging. In vitro, both GQD types exhibit efficient internalization with their intracellular emission maximized at 6 h. The pH‐dependence of this emission can serve as plethora of diagnostic applications. GQDs enable in vivo NIR imaging in live sedated NCr nude mice with IV administration: their NIR emission maximized at 6 h post‐injection is primarily detected in intestine, kidneys, liver, and spleen, however, diminishing to none at 48 h. Ex vivo organ/slice imaging shows significant Tm‐GQD fluorescence signatures in the aforementioned organs/slices. This capability of NIR fluorescence imaging in cells, tissues, and real‐time detection in live animals makes biocompatible rare‐earth metal‐doped GQDs an attractive new candidate for in vitro/in vivo/ex vivo theranostics.

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Section: Resultsmentioning

confidence: 99%

Rare‐Earth Metal Ions Doped Graphene Quantum Dots for Near‐IR In Vitro/In Vivo/Ex Vivo Imaging Applications

Hasan

González-Rodríguez

Lin

et al. 2020

Advanced Optical Materials

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“…For example, rare earth complexes have been widely employed in optical displays, fluorescent probe, luminescent labels and medical diagnosis fields212223242526272829. Nevertheless, their fluorescence stability is always a great concern because rare earth complexes are intrinsically hydrophilic and the fluorescence property is liable to deteriorate in the moist or aqueous environments due to the ligand substitution by water molecules303132. In this aspect, superhydrophobic modification, i.e., making the rare earth materials non-wettable, may provide a feasible solution to the above problem.…”

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confidence: 99%

Fabrication of Superhydrophobic and Luminescent Rare Earth/Polymer complex Films

Wang

Luo

et al. 2016

Sci Rep

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The motivation of this work is to create luminescent rare earth/polymer films with outstanding water-resistance and superhydrophobicity. Specifically, the emulsion polymerization of styrene leads to core particles. Then core-shell-structured polymer nanoparticles are synthesized by copolymerization of styrene and acrylic acid on the core surface. The coordination reaction between carboxylic groups and rare earth ions (Eu3+ and Tb3+) generates uniform spherical rare earth/polymer nanoparticles, which are subsequently complexed with PTFE microparticles to obtain micro-/nano-scaled PTFE/rare earth films with hierarchical rough morphology. The films exhibit large water contact angle up to 161° and sliding angle of about 6°, and can emit strong red and green fluorescence under UV excitation. More surprisingly, it is found that the films maintain high fluorescence intensity after submersed in water and even in aqueous salt solution for two days because of the excellent water repellent ability of surfaces.

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“…[14] Various kinds of luminescent nanoparticles have been developed by doping Eu complexes into a matrix, such as silica or a nonfluorescent polymer. [15][16][17][18][19] But because of self-quenching among Eu complexes, the loading ratio of Eu complexes into the matrix has been kept to low levels to improve the quantum yield (QY). [15,20] Therefore, for these types of fluorescent nanoparticles, the total brightness still has been limited.…”

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confidence: 99%

Semiconducting Polymer Dots Doped with Europium Complexes Showing Ultranarrow Emission and Long Luminescence Lifetime for Time‐Gated Cellular Imaging

Sun¹,

Yu²,

Deng³

et al. 2013

Angew Chem Int Ed

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Doped silica nanoparticles containing two-photon luminescent Eu(iii) complexes for the development of water stable bio-labels

Cited by 20 publications

References 78 publications

Rare‐Earth Metal Ions Doped Graphene Quantum Dots for Near‐IR In Vitro/In Vivo/Ex Vivo Imaging Applications

Rare‐Earth Metal Ions Doped Graphene Quantum Dots for Near‐IR In Vitro/In Vivo/Ex Vivo Imaging Applications

Fabrication of Superhydrophobic and Luminescent Rare Earth/Polymer complex Films

Semiconducting Polymer Dots Doped with Europium Complexes Showing Ultranarrow Emission and Long Luminescence Lifetime for Time‐Gated Cellular Imaging

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