Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

Nasuti, Cinzia; Gabbianelli, Rosita; Falcioni, Maria Letizia; Stefano, Antonio Di; Sozio, Piera; Cantalamessa, Franco

doi:10.1016/j.tox.2006.10.015

Cited by 156 publications

(122 citation statements)

References 52 publications

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“…Because, the PM administration (group C) caused increases of TOS level and decrease of TAC level as compared to control group (group A). In accordance with our findings, recent investigations clearly indicated that PM-induced oxidative stress leads to biochemical and functional changes in organisms (Nasuti et al 2007;Gabbianelli et al 2009;Issam et al 2011). The present study also demonstrated that the reduction of PM induced oxidative and DNA damages was caused by the protective effect of OLE.…”

Section: Discussionsupporting

confidence: 93%

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

2012

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Permethrin is a common synthetic chemical, widely used as an insecticide in agriculture and other domestic applications. The previous reports indicated that permethrin is a highly toxic synthetic pyrethroid pesticide to human and environmental health. Therefore, the present experiment was undertaken to determine the effectiveness of olive leaf extract in modulating the permethrin induced genotoxic and oxidative damage in rats. The animals used were broadly divided into four (A, B, C and D) experimental groups. Group A rats served as control animals and received distilled water intraperitoneally (n = 5). Groups B and C rats received intraperitoneal injections of permethrin (60 mg kg -1 b.w) and olive leaf extract (500 mg kg -1 b.w), respectively. Group D rats received permethrin (60 mg kg -1 b.w) plus olive leaf extract (500 mg kg -1 b.w). Rats were orally administered their respective feed daily for 21 days. At the end of the experiment rats were anesthetized and serum and bone marrow cell samples were obtained. Genotoxic damage was assessed by micronucleus and chromosomal aberration assays. Total antioxidant capacity and total oxidant status were also measured in serum samples to assess oxidative status. Treatment of Group B with permethrin resulted in genotoxic damage and increased total oxidant status levels. Permethrin treatment also significantly decreased (P \ 0.05) total antioxidant capacity level when compared to Group A rats. Group C rats showed significant increases (P \ 0.05) in total antioxidant capacity level and no alterations in cytogenetic parameters. Moreover, simultaneous treatments with olive leaf extract significantly modulated the toxic effects of permethrin in Group D rats. It can be concluded that olive leaf extract has beneficial influences and could be able to antagonize permethrin toxicity. As a result, this investigation clearly revealed the protective role of olive leaf extract against the genetic and oxidative damage by permethrin in vivo for the first time.

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Section: Discussionsupporting

confidence: 93%

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

2012

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“…19 These findings were also supported by the findings of Yousef et al in sheep, 9 and Yousef et al 46 in rabbits. This increase in leukocyte count may indicate an activation of the animal's defense mechanism and immune system.…”

Section: Discussionsupporting

confidence: 67%

“…[16][17][18] Synthetic pyrethroids also have the ability to disrupt biochemical, hematological, and reproductive parameters. 19 The toxicity of pyrethroid insecticides in mammals have received great attention in the recent years because animals exposed to these insecticides have exhibited changes in their physiological activities besides other pathological features. 20 Oxidative stress and reactive oxygen species so produced in response to stress, as well as endocrine disturbance are among the most significant effects of pesticide toxicology.…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Das¹,

Ghosh²,

Paramanik³

et al. 2017

Toxicol Forensic Med Open J

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CitationPesticides are used frequently and may have various adverse effects on human health in different ways. Cypermethrin (CYP) is a synthetic type II pyrethroid pesticide that has been used extensively to control a wide variety of pests in agriculture, forestry, horticulture, and public health. Objectives: This study aimed to investigate the dose-dependent hematological, hepatic and gonadal toxicity of CYP in mature male and female Wistar rats. Methods: Rats were randomly divided into nine groups, different doses of CYP were administered for 14 consecutive days and different hematological, hepatic and gonadal parameters were assayed. Results: Erythrocyte count, hemoglobin percentage, hepatic reduced glutathione (GSH) content and sperm count were significantly diminished. Serum aspartic and alanine transaminase, hepatic malondialdehyde (MDA), testicular cholesterol content were increased following CYP treatment in male rats at 40 and 80 mg/kg body weight (1/9 and 1/4.5 LD 50 ). Elevated ovarian cholesterol content and decreased 17β hydroxy steroid dehydrogenase (HSD) levels were also observed in CYP-exposed female rats at a dose level of 34.33 and 51.5 mg/kg body wt. (1/9 and 1/6 LD 50 ). Conclusion: Taken together, CYP initiated hematological, hepatic and gonadal toxicity in mature male rats with a body weight of 40 mg/kg (1/9 LD 50 ) and gonadal toxicity in mature female rats with a body weight of 34.33 mg/kg (1/9 LD 50 ) and above.

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“…Lower DA levels and accelerated DA turnover following early life PERM treatment was also observed (Nasuti et al, 2007). Nurr1 is a transcription factor belonging to the nuclear receptor family and it regulates the development and maintenance of dopaminergic neurons.…”

Section: Introductionmentioning

confidence: 96%

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

et al. 2013

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a b s t r a c tPesticide exposure during brain development could represent an important risk factor for the onset of neurodegenerative diseases. Previous studies investigated the effect of permethrin (PERM) administered at 34 mg/kg, a dose close to the no observable adverse effect level (NOAEL) from post natal day (PND) 6 to PND 21 in rats. Despite the PERM dose did not elicited overt signs of toxicity (i.e. normal body weight gain curve), it was able to induce striatal neurodegeneration (dopamine and Nurr1 reduction, and lipid peroxidation increase). The present study was designed to characterize the cognitive deficits in the current animal model. When during late adulthood PERM treated rats were tested for spatial working memory performances in a T-maze-rewarded alternation task they took longer to choose for the correct arm in comparison to age matched controls. No differences between groups were found in anxiety-like state, locomotor activity, feeding behavior and spatial orientation task. Our findings showing a selective effect of PERM treatment on the T-maze task point to an involvement of frontal cortico-striatal circuitry rather than to a role for the hippocampus. The predominant disturbances concern the dopamine (DA) depletion in the striatum and, the serotonin (5-HT) and noradrenaline (NE) unbalance together with a hypometabolic state in the medial prefrontal cortex area. In the hippocampus, an increase of NE and a decrease of DA were observed in PERM treated rats as compared to controls. The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 g/L and it was completely eliminated after 96 h.

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Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids

Cited by 156 publications

References 52 publications

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

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