Dopaminergic Stimulation of the Immune Reaction: Interaction of Serotoninergic and Dopaminergic Systems in Neuroimmunomodulation

Devoino, L. V.; Альперина, Е. Л.; Идова, Г. В.

doi:10.3109/00207458808990716

Cited by 24 publications

(14 citation statements)

References 29 publications

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“…Corticosteroids are responsible for this effect [11], and a significant increase of corticosterone was observed during immobilization and the recovery period. The comparison of the immobilization-induced increase of extracellular 5-HIAA in the NRD and the reduction of pan-T lymphocytes and T helper lymphocytes observed during and after this stressor is in accordance with, but does not prove the view of Devoino et al [1,2] that 5-HT has an inhibitory effect on immune functions mediated via the HPA axis. This negative relationship could be con firmed only partly by the light-dark cycle study.…”

Section: Discussionsupporting

confidence: 68%

“…The serotoninergic transmitter system in the central nervous system (CNS) is involved in the regulation of behavioural and physiological processes, including the release of corticotropin-releasing factor (CRF) in the hypothalamus. Devoino et al [ 1,2] provided data that serotonin (5-HT) modulates immune functions mainly by its effect on CRF release. However, these find ings disagreed totally [3] or at least partly [4] with pre viously published results.…”

Section: Introductionmentioning

confidence: 99%

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Immobilization and Light-Dark Cycle-Induced Modulation of Serotonin Metabolism in Rat Brain and of Lymphocyte Subpopulations: In vivo Voltammetric and FACS Analyses

Wesemann¹,

Gemsa

Hasse³

et al. 1993

Neuropsychobiology

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The effect of immobilization and light-dark cycle on the serotoninergic system of the n. raphe dorsalis and on the distribution of blood lymphocyte subpopulations was studied in the rat. As was shown by in vivo voltammetry, 10 min immobilization enhanced serotonin metabolism with a maximum 15 min after immobilization. The distribution of the blood lymphocytes into subpopulations was also affected: pan-T and T helper lymphocytes were reduced during immobilization and reached minimum values after 20 min recovery. The circadian rhythms of serotonin metabolism and the distribution of pan-T and T helper cells exhibited a slight phase shift if compared with each other.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Immobilization and Light-Dark Cycle-Induced Modulation of Serotonin Metabolism in Rat Brain and of Lymphocyte Subpopulations: In vivo Voltammetric and FACS Analyses

Wesemann¹,

Gemsa

Hasse³

et al. 1993

Neuropsychobiology

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“…Intensification of immune reactions with the development of aggression can be due to increased activity of dopaminergic (DA) system of the brain, because dopamine dependence of aggression was demonstrated in neurophysiological and pharmacological studies [8]. On the other hand, DA system contributes to regulation of immune response, and its immunostimulating effect is explained by increased count of CD4 + T-helpers in the bone marrow [1,4,6,[10][11][12]. All this prompted us to investigate changes in the count of CD4 T-lymphocytes in the bone marrow during the development of aggression in a zoosocial conflict.…”

mentioning

confidence: 99%

Changed count of CD4+ T-lymphocytes in the bone marrow of aggressive CBA mice

et al. 1997

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Enhanced immune response of aggressive CBA mice after 10 daily confrontations in sensory contact on day 4 after immunization with sheep red blood cells (5x108) is paralleled by an increase in the count of CD4 § T-cells in the bone marrow. Aggressive behavior, weight of the spleen, and count of CD4 § T-helpers in the bone marrow (which is increased only in aggressors with a history of at least 3 victories) are correlated. The effect of aggressive behavior on immunity can be caused by changes of the neurochemical status of the brain and determined by an increase in the CD4 § T-helper count.

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“…At the same time, when mice are treated with ICI 174 864 against the background of the administration of haloperidol, the immune response corresponds essentially to the control value, and does not reach the level achieved when ICI 174 864 is administered alone (see Table 1). Our previous data suggest that the thymus is the peripheral link in the realization of the immunostimulatory influence of the dopaminergic system [2,9].…”

Section: Resultsmentioning

confidence: 99%

Participation of opiate δ-receptors in immunomodulation

Cheido¹,

Идова²

1994

Neurosci Behav Physiol

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The activation of the opiate delta-receptors by the highly specific agonist DSLET evokes an immunoinhibitory effect in CBA mice which disappears with preliminary blockade of S2 serotonin receptors by cyproheptadine. The blockade of delta-receptors by the antagonist ICI 174,864 leads to stimulation of the immune response, which is tested on the basis of the number of rosette-forming cells. Neither stimulation nor suppression of immunogenesis are manifested in animals with a transsected hypophyseal stalk; this suggests the central action of the opioids. The increase in the immune response obtained with the administration of ICI 174,864 is associated with the dopaminergic system, since it is prevented by haloperidol. It was demonstrated that the thymus participates in the immune-stimulating influence of ICI 174,864.

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Dopaminergic Stimulation of the Immune Reaction: Interaction of Serotoninergic and Dopaminergic Systems in Neuroimmunomodulation

Cited by 24 publications

References 29 publications

Immobilization and Light-Dark Cycle-Induced Modulation of Serotonin Metabolism in Rat Brain and of Lymphocyte Subpopulations: In vivo Voltammetric and FACS Analyses

Immobilization and Light-Dark Cycle-Induced Modulation of Serotonin Metabolism in Rat Brain and of Lymphocyte Subpopulations: In vivo Voltammetric and FACS Analyses

Changed count of CD4+ T-lymphocytes in the bone marrow of aggressive CBA mice

Participation of opiate δ-receptors in immunomodulation

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