Changed count of CD4+ T-lymphocytes in the bone marrow of aggressive CBA mice

Abstract

Enhanced immune response of aggressive CBA mice after 10 daily confrontations in sensory contact on day 4 after immunization with sheep red blood cells (5x108) is paralleled by an increase in the count of CD4 § T-cells in the bone marrow. Aggressive behavior, weight of the spleen, and count of CD4 § T-helpers in the bone marrow (which is increased only in aggressors with a history of at least 3 victories) are correlated. The effect of aggressive behavior on immunity can be caused by changes of the neurochemical status of the brain and determined by an increase in the CD4 § T-helper count.

Synchronization of Immune and Psychic Systems Associated With Social Stress

“…After 20-day confrontations the number of (CD8+) has increased not only in the control group but also in the group with 10-day confrontations (Idova et al, 2000). The data are confirmed by the experiment where the number of (CD8+) in peripheral blood has been decreased during 2 hours in rats which suffered defeat (Stefanski et al, 1996).…”