Dopaminergic Neurogenetics of Sleep Disorders in Reward Deficiency Syndrome (RDS)

Blum, Kenneth; Oscar‐Berman, Marlene; Badgaiyan, Rajendra D.; Khurshid, Khurshid A.; Gold, Mark S.

doi:10.4172/2167-0277.1000e126

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…The dopamine receptor-signaling pathways regulating sleep, learning, and its plasticity are well known [ 83 , 84 ]. Sleep disorders and sleep deprivation have been correlated with the dopaminergic, cholinergic, and GABAergic regulation of synaptic transmission, each of which were terms that were significantly enriched for genes that were down-regulated in our study [ 85 , 86 , 87 , 88 , 89 ]. These observations support our hypothesis that REM sleep loss negatively affect the genes and processes related to synaptic homeostasis in the brain.…”

Section: Discussionmentioning

confidence: 95%

“…Further, microarrays have shown that there are transcript level variations in many genes involved in the regulation of reactive oxygen species (ROS), including heme oxygenase, superoxide dismutase, and catalase in patients with obstructive sleep apnea [ 84 ]. The dopamine receptor-signaling pathway regulating sleep, learning, and its plasticity are well known [ 85 , 86 ]. Sleep disorders and sleep deprivation have been correlated with the dopaminergic, cholinergic, and GABAergic regulation of synaptic transmission, each of which are terms that were significantly enriched for genes that were down-regulated in our study [ 55 , 87 , 88 , 89 , 90 ].…”

Section: Introductionmentioning

confidence: 99%

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Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

2020

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Sleep is essential for the survival of most living beings. Numerous researchers have identified a series of genes that are thought to regulate “sleep-state” or the “deprived state”. As sleep has a significant effect on physiology, we believe that lack of total sleep, or particularly rapid eye movement (REM) sleep, for a prolonged period would have a profound impact on various body tissues. Therefore, using the microarray method, we sought to determine which genes and processes are affected in the brain and liver of rats following nine days of REM sleep deprivation. Our findings showed that REM sleep deprivation affected a total of 652 genes in the brain and 426 genes in the liver. Only 23 genes were affected commonly, 10 oppositely, and 13 similarly across brain and liver tissue. Our results suggest that nine-day REM sleep deprivation differentially affects genes and processes in the brain and liver of rats.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

2020

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“…In terms of positive sleep aspects, earlier studies have shown that KB220Z can actually improve sleep [ 52 ] and even eliminate posttraumatic stress disorder (PTSD)/ADHD induced unwanted terrifying lucid dreams [ 53 – 54 ]. Along these lines, qEEG studies utilizing KB220Z has revealed reduced widespread theta activity with concomitant increase in both alpha and low beta waves in abstinent psychostimulant abusers [ 37 ] as well as in alcoholics and heroin addicts [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional Clinician Improving Focus, Motivation and Overall Sensory Input Following Chronic Intake

Duquette

Mattiace

Blum

et al. 2016

Clin Med Rev Case Rep

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Background With neurogenetic and epigenetic tools utilized in research and neuroimaging, we are unraveling the mysteries of brain function, especially as it relates to Reward Deficiency (RDS). We encourage the development of pharmaceuticals or nutraceuticals that promote a reduction in dopamine resistance and balance brain neurochemistry, leading to dopamine homeostasis. We disclose self-assessment of a highly functional professional under work-related stress following KB220Z use, a liquid (aqua) nano glutaminergic-dopaminergic optimization complex (GDOC). Case presentation Subject took GDOC for one month. Subject self-administered GDOC using one-half-ounce twice a day. During first three days, unique brain activation occurred; resembling white noise after 30 minutes and sensation was strong for 45 minutes and then dissipated. He described effect as if his eyesight improved slightly and pointed out that his sense of smell and sleep greatly improved. Subject experienced a calming effect similar to meditation that could be linked to dopamine release. He also reported control of going over the edge after a hard day’s work, which was coupled with a slight increase in energy, increased motivation to work, increased focus and multi-tasking, with clearer purpose of task at hand. Subject felt less inhibited in a social setting and suggested Syndrome that GDOC increased his Behavior Activating System (reward), while having a decrease in the Behavior Inhibition System (caution). Conclusion These results and other related studies reveal an improved mood, work-related focus, and sleep. These effects as a subjective feeling of brain activation maybe due to direct or indirect dopaminergic interaction. While this case is encouraging, we must await more research in a larger randomized placebo-controlled study to map the role of GDOC, especially in a nano-sized product, to determine the possible effects on circuit inhibitory control and memory banks and the induction of dopamine homeostasis independent of either hypo- or hyper-dopaminergic traits/states.

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“…Further, microarrays have shown that there are transcript level variations in many genes involved in the regulation of reactive oxygen species (ROS), including heme oxygenase, superoxide dismutase, and catalase, in patients with obstructive sleep apnea [85]. The dopamine receptor-signaling pathway regulating sleep, learning, and its plasticity are well known [86,87]. Sleep disorders and sleep deprivation have been correlated with dopaminergic, cholinergic, and GABAergic regulation of synaptic transmission, each of which were terms that were significantly enriched for genes that were downregulated in our study [56,88–91].…”

Section: Introductionmentioning

confidence: 99%

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivation

Pandey

Oliver

Kar

2019

Preprint

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Short title:REM sleep deprivation differentially affects the genes of liver and brain in rats. Highlights of the study: Microarray analysis compared the expression pattern of genes related to many biological, molecular and physiological processes in brain and liver. Analysis revealed about the basic genetic tool-kit involved with REM sleep deprivation and its loss in brain and liver. Many of the genes involved in critical physiological processes like apoptosis and circadian rhythms are found differentially expresses in brain and liver. AbstractFundamental questions about sleep and its universal existence remain elusive. The common presence of sleep across phyla suggests that it must serve some indispensable cellular and/or molecular function needed for survival. Microarray studies, performed in several model systems, have identified classes of genes that are believed to regulate "sleep-state" or viceversa. This has led to the following concepts: first, a function of sleep is to maintain synaptic homeostasis; second, sleep is a stage of macromolecule biosynthesis which is needed during the waking period; third, extending wakefulness leads to the downregulation of several important metabolic pathways which needs to be balanced for extended survival; and, fourth, extending wakefulness leads to endoplasmic reticulum stress. In human sleep studies, microarrays are being pragmatic to the identification of biomarkers for sleepiness and for the common sleep disorders. This study tries to find out the correlative processes which happen across different tissue system in the maintenance of sleep. We compared the gene expression profile in brain and liver due to REM sleep deprivation. Our result suggests that sleep deprivation affects a different set of genes in the brain and liver.

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Dopaminergic Neurogenetics of Sleep Disorders in Reward Deficiency Syndrome (RDS)

Cited by 8 publications

References 29 publications

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional Clinician Improving Focus, Motivation and Overall Sensory Input Following Chronic Intake

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivation

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