Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional Clinician Improving Focus, Motivation and Overall Sensory Input Following Chronic Intake

Abstract

Background With neurogenetic and epigenetic tools utilized in research and neuroimaging, we are unraveling the mysteries of brain function, especially as it relates to Reward Deficiency (RDS). We encourage the development of pharmaceuticals or nutraceuticals that promote a reduction in dopamine resistance and balance brain neurochemistry, leading to dopamine homeostasis. We disclose self-assessment of a highly functional professional under work-related stress following KB220Z use, a liquid (aqua) nano glutaminergic-dopaminergic optimization complex (GDOC). Case presentation Subject took GDOC for one month. Subject self-administered GDOC using one-half-ounce twice a day. During first three days, unique brain activation occurred; resembling white noise after 30 minutes and sensation was strong for 45 minutes and then dissipated. He described effect as if his eyesight improved slightly and pointed out that his sense of smell and sleep greatly improved. Subject experienced a calming effect similar to meditation that could be linked to dopamine release. He also reported control of going over the edge after a hard day’s work, which was coupled with a slight increase in energy, increased motivation to work, increased focus and multi-tasking, with clearer purpose of task at hand. Subject felt less inhibited in a social setting and suggested Syndrome that GDOC increased his Behavior Activating System (reward), while having a decrease in the Behavior Inhibition System (caution). Conclusion These results and other related studies reveal an improved mood, work-related focus, and sleep. These effects as a subjective feeling of brain activation maybe due to direct or indirect dopaminergic interaction. While this case is encouraging, we must await more research in a larger randomized placebo-controlled study to map the role of GDOC, especially in a nano-sized product, to determine the possible effects on circuit inhibitory control and memory banks and the induction of dopamine homeostasis independent of either hypo- or hyper-dopaminergic traits/states.

Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

“…In summary [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,…”

Stakekold ZXSY Brazil, Precision Medicine in Pediatric Clinic: Reward Deficiency Syndrome (RDS) Is Surprisingly Evolving and Found Everywhere: Is It “Blowing in the Wind”? Yes, but how Syndrome Z.

“…Since 1995, Blum et al have studied dopamine-dependent behaviors associated with epigenetic changes, the presence of polymorphisms, and several other mechanisms, which produce the hypodopaminergic state or syndrome (Sd) of the dysfunctional reward system (RDS) [3][4][5][6]. Converging evidence from epidemiological and neurobiological studies that ACE and PTSD as sexual and physical abuse, are closely related to lasting brain dysfunctions that affect physical and mental health, producing traumatic signatures, tonsillar neuroadaptations, which by activation of these neurons of "defense'' and mirror neurons, unconsciously reproduce what they received from their parents (family psychodynamics) and reproduce in many cases a chronic child neglect or chronic unconscious parental alienation [7][8][9].…”

“…RDS children present emotional and cognitive intelligence, speech delay, are pragmatic, intense, perform hyperfocus in areas of interest, playful, empathetic, perceive the emotional state of another child, exchange looks with the environment, perceive three to four objects in the same instant, present subitization with geometric figures, difficulty in mathematics and grammar, hyperkinetic, difficulty concentrating in the classroom with mental fatigue, have deficits in inhibitory control, and emotional dysregulation, primary insomnia, usually lose their reason in family conflicts [3][4][5][6].…”

Stakekold ZXSY Brazil, Precision Medicine in Pediatric Clinic: Reward Deficiency Syndrome (RDS) Is Surprisingly Evolving and Found Everywhere: Is It "Blowing in the Wind"? Yes, but how Syndrome Z.

“…Since 1995, Blum et al have studied dopamine-dependent behaviors associated with epigenetic changes, the presence of polymorphisms, and several other mechanisms, which produce the hypodopaminergic state or syndrome (Sd) of the dysfunctional reward system (RDS) [3][4][5][6].…”

“…We clinically update with hierarchical sequence the etiopathogenesis of RDS Spectrum Disorders, adding descriptions of the unconscious effects of psychoanalysis that neurobehavioral neurobiology produces, without theory [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”