Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task

Winstanley, Catharine A.; Zeeb, Fiona D.; Bedard, Amanda; Fu, Kent; Lai, Barbara; Steele, Christina; Wong, Adeline

doi:10.1016/j.bbr.2010.02.044

Cited by 76 publications

(64 citation statements)

References 72 publications

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“…This region has been coupled to impulsivity and motivation processes 55 known to be affected both in individuals with prenatal exposure to alcohol 56 and those with ADHD. 57 The lateral OFC is important for adaptive learning and has recently been linked to conflict adaptation during response inhibition.…”

Section: Discussionmentioning

confidence: 99%

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Meer¹,

Hartman²,

Rooij³

et al. 2017

JPN

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Section: Discussionmentioning

confidence: 99%

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Meer¹,

Hartman²,

Rooij³

et al. 2017

JPN

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“…Testing took place within 16 standard five-hole operant chambers, each supplemented with two retractable levers and enclosed in a ventilated, sound-attenuating cabinet (Med Associates, VT, USA; for a detailed description, see Winstanley et al, 2010). The chambers were controlled by software written in Med-PC by CAW, running on an IBMcompatible computer.…”

Section: The Rcet Training and Testingmentioning

confidence: 99%

“…Briefly, animals learned to make a nosepoke response in an illuminated aperture within 5 s to obtain reward, as per five-choice serial reaction-time task (5CSRTT) training (Winstanley et al, 2010). In subsequent sessions, animals were trained to respond on two retractable levers at a fixed ratio 1 schedule for reward.…”

Section: The Rcet Training and Testingmentioning

confidence: 99%

Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort

Hosking

Cocker

Winstanley

2014

Neuropsychopharmacol

117

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Personal success often requires the choice to expend greater effort for larger rewards, and deficits in such effortful decision making accompany a number of illnesses including depression, schizophrenia, and attention-deficit/hyperactivity disorder. Animal models have implicated brain regions such as the basolateral amygdala (BLA) and anterior cingulate cortex (ACC) in physical effort-based choice, but disentangling the unique contributions of these two regions has proven difficult, and effort demands in industrialized society are predominantly cognitive in nature. Here we utilize the rodent cognitive effort task (rCET), a modification of the five-choice serial reactiontime task, wherein animals can choose to expend greater visuospatial attention to obtain larger sucrose rewards. Temporary inactivation (via baclofen-muscimol) of BLA and ACC showed dissociable effects: BLA inactivation caused hard-working rats to 'slack off' and 'slacker' rats to work harder, whereas ACC inactivation caused all animals to reduce willingness to expend mental effort. Furthermore, BLA inactivation increased the time needed to make choices, whereas ACC inactivation increased motor impulsivity. These data illuminate unique contributions of BLA and ACC to effort-based decision making, and imply overlapping yet distinct circuitry for cognitive vs physical effort. Our understanding of effortful decision making may therefore require expanding our models beyond purely physical costs.

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“…Individual fMRI time series were filtered (Fox et al, 2009;Van Dijk et al, 2010) using a general linear model (GLM). The GLM contained the following: 1-6, six regressors related to between-scan head movements from the realignment procedure; 7, a constant term; 8, a linear trend; 9, the average signal from a white-matter mask; 10, the average signal from a CSF mask; and 11, the average signal from a gray-matter mask.…”

Section: Methodsmentioning

confidence: 99%

“…Important progress has been made in understanding how the OFC contributes to reward expectation, valuation, and decisionmaking (Sescousse et al, 2010;Padoa-Schioppa, 2011;Rushworth et al, 2012;Rudebeck and Murray, 2014;Howard et al, 2015;Stalnaker et al, 2015). However, although the frontal lobes receive strong projections from dopaminergic [dopamine (DA)] neurons in the midbrain (Swanson, 1982;Goldman-Rakic et al, 1992), and DA in the prefrontal cortex (PFC) has been associated with specific cognitive functions such as working memory and cognitive control (Miller and Cohen, 2001;Cools, 2016), characterizations of the role of DA in the OFC have remained relatively vague.…”

Section: Introductionmentioning

confidence: 99%

Dopamine Modulates the Functional Organization of the Orbitofrontal Cortex

Kahnt

Tobler

2017

J. Neurosci.

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Neuromodulators such as dopamine can alter the intrinsic firing properties of neurons and may thereby change the configuration of larger functional circuits. The primate orbitofrontal cortex (OFC) receives dopaminergic input from midbrain nuclei, but the role of dopamine in the OFC is still unclear. Here we tested the idea that dopaminergic activity changes the pattern of connectivity between the OFC and the rest of the brain and thereby reconfigures functional networks in the OFC. To this end, we combined double-blind, placebocontrolled pharmacology [D 2 receptor (D2R) antagonist amisulpride] in humans with resting-state functional magnetic resonance imaging and clustering methods. In the placebo group, we replicated previously observed parcellations of the OFC into two and six subregions based on connectivity patterns with the rest of the brain. Most importantly, while the twofold clustering did not differ significantly between groups, blocking D2Rs significantly changed the composition of the sixfold parcellation, suggesting a dopaminedependent reconfiguration of functional OFC subregions. Moreover, multivariate decoding analyses revealed that amisulpride changed the whole-brain connectivity patterns of individual OFC subregions. In particular, D2R blockade shifted the balance of OFC connectivity from associative areas in the temporal and parietal lobe toward functional connectivity with the frontal cortex. In summary, our results suggest that dopamine alters the composition of functional OFC circuits, possibly indicating a broader role for neuromodulators in the dynamic reconfiguration of functional brain networks.

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Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task

Cited by 76 publications

References 72 publications

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Dissociable Contributions of Anterior Cingulate Cortex and Basolateral Amygdala on a Rodent Cost/Benefit Decision-Making Task of Cognitive Effort

Dopamine Modulates the Functional Organization of the Orbitofrontal Cortex

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