Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Meer, Dennis van der; Hartman, Catharina A.; Rooij, Daan van; Franke, Barbara; Heslenfeld, Dirk J.; Oosterlaan, Jaap; Faraone, Stephen V.; Buitelaar, Jan K.; Hoekstra, Pieter J.

doi:10.1503/jpn.150350

Cited by 8 publications

(6 citation statements)

References 69 publications

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“…We found that maternal smoking during pregnancy increased the risk of behavioral problems 1.5-fold in MLPs, similar to what has been reported for FTs [35,36], EPs [15,20,37], and in the only further available study that investigated this factor specifically for MLPs, though focusing on school problems [7]. A possible explanation is that maternal smoking during pregnancy leads to lower dopamine signaling, reducing response inhibition in the child [38]. Another explanation is that maternal smoking is associated with deterioration of placental function [39], increasing the risk of chronic fetal hypoxia [40], in turn causing structural brain changes associated with both internalizing [41] and externalizing [42] problems.…”

Section: Discussionsupporting

confidence: 69%

Risk factors for emotional and behavioral problems in moderately-late preterms

et al. 2019

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Objective To assess which factors, including maternal, lifestyle, pregnancy- and delivery-related, fetal and neonatal factors adjusted for socio-economic status, are related to emotional and behavioral problems in moderately-late preterm born children (MLPs; gestational age 32.0–35.9 weeks) at 4 years of age. MLPs are at greater risk of emotional and behavioral problems than full-term born children. Especially for MLPs, knowledge about factors that increase or decrease the risk of emotional and behavioral problems is scarce. Design and setting We assessed emotional and behavioral problems in 809 MLPs between ages 41 and 49 months from the prospective community-based Longitudinal Preterm Outcome Project (LOLLIPOP), using the parent-reported Child Behavior Checklist (CBCL). We collected potential risk factors from hospital records and parental questionnaires. Univariable and multiple logistic regression analyses were applied. Main outcome measures (Sub)clinical CBCL scores. Results Perinatal infection increased the risk of CBCL total problem scores with an OR 2.22 ( p <0.01). Perinatal infection, maternal smoking, and male gender increased the risk of CBCL externalizing problem scores with ORs between 1.64 and 2.46 (all p <0.05). Multiple birth decreased the risk of CBCL internalizing problem scores with an OR 0.63 ( p <0.05). Conclusions Risk factors for behavioral problems in MLPs are male gender, perinatal infection and maternal smoking, the latter two being potentially modifiable. Multiple birth is a protective factor for emotional problems in MLPs. These results suggest potential factors for targeting preventive intervention in MLPs, comprising the large majority of all preterm born children.

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Section: Discussionsupporting

confidence: 69%

Risk factors for emotional and behavioral problems in moderately-late preterms

et al. 2019

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“…A review of the last 4.5 years of the literature included 34 studies that focused on ADHD diagnosis and related symptoms. A majority of studies focused their environmental exposure on related to psychosocial [67][68][69][70][71][72][73][74][75][76][77], stress and adversity [27,75,[77][78][79][80][81][82][83][84], and trauma-related exposures [85]. Very few focused on toxicant exposure such as blood lead levels [86, 87••, 88], phthalate metabolites [89], and organophosphate pesticide exposure [90].…”

Section: Attention Deficit Hyperactivity Disordermentioning

confidence: 99%

Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications

Musci

Augustinavicius

Volk

2019

Curr Psychiatry Rep

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Purpose of Review-We identify the recent evidence for gene-by-environment interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as well as environmental exposures and how they interact to predict psychiatric disorders and psychiatric symptomatology. We direct our focus on the psychiatric outcomes that were focused on by the Psychiatric Genetics Consortium. Recent Findings-Many of the studies focus on candidate gene approaches, with most of the studies drawing upon previous literature to decide the genes of interest. Other studies used a genome-wide approach. While some studies demonstrated positive replication of previous findings, replication is still an issue within gene-by-environment interaction studies. Summary-Gene-by-environment interaction research in psychiatry globally suggests some susceptibility to environmental exposures based on genotype; however, greater clarity is needed around the idea that genetic risk may not be disorder specific.

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“…25 Studies in human populations have found gene × environment interactions with dopamine transporter (DAT), prenatal adversity and attention deficit hyperactivity disorder symptoms in children. 26,27 Dopamine transporter genotype has been associated with its availability in human striatum to metabolise dopamine, 28 influencing the rate dopamine is cleared from the synapse. Similar to the dopamine transporter, catechol-O-methyltransferase (COMT) metabolises dopamine and a common functional SNP is associated with its activity in the prefrontal cortex of humans, 29 although, to our knowledge, gene × environment studies on these mechanisms have not been performed.…”

mentioning

confidence: 99%

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

Lauby

Chatterjee

Pan

et al. 2019

J Neuroendocrinology

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Rat mothers exhibit natural variations in care and can shape offspring adult behaviour and their maternal care by affecting the dopaminergic system. We explored whether genotype and gene × environment interactions are involved in these processes in nulliparous female offspring. We assessed maternal licking/grooming toward individual female pups during the first week postpartum and dopamine‐related behaviour of the offspring in adulthood. Behaviours explored included strategy shifting, impulsive action and sucrose preference. Single nucleotide polymorphisms in the dopamine receptor 2, dopamine transporter and catechol‐O‐methyltransferase genes were examined in relation to offspring behaviour and baseline dopamine turnover in select brain regions. Dopamine receptor 2 (RS107017253) variation moderated, or interacted with, the relationship between early‐life licking received and behaviour. Specifically, offspring with the A/A genotype showed a significant correlation between early‐life licking received and behaviour. Offspring with the A/G and G/G genotypes did not show this relationship. Dopamine transporter gene variation affected offspring behaviour regardless of early‐life licking received. Our findings suggest that genotype can directly affect dopamine‐related behaviours and alter the sensitivity of offspring to the maternal environment. This could be informative on how maternal care is transmitted between generations of female offspring.

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Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

Cited by 8 publications

References 69 publications

Risk factors for emotional and behavioral problems in moderately-late preterms

Risk factors for emotional and behavioral problems in moderately-late preterms

Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications

Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring

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