Dopaminergic modulation of semantic network activation

Kischka, Udo; Kammer, Thomas; Maier, Sabine; Weisbrod, Matthias; Thimm, Markus; Spitzer, Manfred

doi:10.1016/0028-3932(96)00024-3

Cited by 139 publications

(125 citation statements)

References 43 publications

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“…This also suggests that increased levels of catecholamines may increase the focus of activation in semantic networks, and therefore it should decrease the spread of activation. Previous behavioral research demonstrated that administration of L-Dopa resulted in restriction of the semantic network in a lexical priming experiment (Angwin et al, 2004;Kischka et al, 1996). This result along with studies of semantic network spread in neurologically impaired patients such as schizophrenic patients and patients with Parkinson's disease, suggests that dopamine may play a role in modulation of semantic processing (Spitzer et al, 1993, Spitzer et al, 1994Watters & Patel, 1999).…”

Section: Introductionmentioning

confidence: 86%

“…The sample size in this within-subject design would be expected to yield a significant effect of L-DOPA since previous experiments on semantic priming yielded significant results with a similar number of between-subject comparisons (Kischka et al, 1996). They were all native English speakers, right handed, as assessed with the Edinburgh Handedness Inventory (Oldfield, 1971), with no history of psychiatric or neurological problems, or of learning disabilities such as dyslexia.…”

Section: Research Participantsmentioning

confidence: 99%

“…Understanding the effects of pharmacological manipulation on semantic networks may have implications ranging from language perception (Angwin et al, 2004;Kischka et al, 1996) to problem solving (Beversdorf et al, 1999;Beversdorf et al, 2002;Silver et al, 2004). This may also reveal insight into the impairments exhibited by some patient populations (Arnott et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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We describe an fMRI experiment examining the functional connectivity (FC) between regions of the brain associated with semantic and phonological processing. We wished to explore whether L-Dopa administration affects the interaction between language network components in semantic and phonological categorization tasks, as revealed by FC. We hypothesized that L-Dopa would decrease FC due to restriction of the semantic network. During two test sessions (placebo and L-Dopa) each participant performed two fMRI runs, involving phonological and semantic processing. A number of brain regions commonly activated by the two tasks were chosen: left inferior frontal, left posterior temporal and left fusiform gyri, and left parietal cortex. FC was calculated and further analyzed for effects of either the drug or task. No drug effect was found. A significant main effect for task was found, with a greater average correlation for the phonological task than for the semantic task. These findings suggest that language areas are activated in a more synchronous manner for phonological tasks than for semantic tasks. This may relate to the fact that phonological tasks are mediated to a greater extent within language areas, whereas semantic tasks likely require greater interaction outside of the language areas. Alternatively, this may be due to differences in the attentional requirements of the two tasks.

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Section: Introductionmentioning

confidence: 86%

Section: Research Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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show abstract

“…It could also correspond to an 'integrated meaning' of the two primes if their RU and UR associates were able to activate their own common associates to make a link between the two primes. Indirect associations between a single prime and a target are reported to allow for activation and priming effects in the experimental literature and in cortical network models of single priming (McNamara and Altarriba 1988;Kiefer et al 1998Kiefer et al , 2005Kischka et al 1996;see Brunel and Lavigne 2009 for a review and model). In single priming, indirect (step2) associations are reported to generate priming.…”

Section: Integration In Mixed Meaningsmentioning

confidence: 99%

Dynamics of the semantic priming shift: behavioral experiments and cortical network model

et al. 2012

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Multiple semantic priming processes between several related and/or unrelated words are at work during the processing of sequences of words. Multiple priming generates rich dynamics of effects depending on the relationship between the target word and the first and/or second prime previously presented. The experimental literature suggests that during the on-line processing of the primes, the activation can shift from associates to the first prime to associates to the second prime. Though the semantic priming shift is central to the on-line and rapid updating of word meanings in the working memory, its precise dynamics are still poorly understood and it is still a challenge to model how it functions in the cerebral cortex. Four multiple priming experiments are proposed that crossmanipulate delays and association strength between the primes and the target. Results show for the first time that association strength determines complex dynamics of the semantic priming shift, ranging from an absence of a shift to a complete shift. A cortical network model of spike frequency adaptive neuron populations is proposed to account for the non-continuous evolution of the priming shift over time. It allows linking the dynamics of the priming shift assessed at the behavioral level to the nonlinear dynamics of the firing rates of neurons populations.

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“…In a conventional semantic priming paradigm with no motivationally relevant words, L-dopa led to a small but significant slowing of RT to target words that were peripherally related to their respective (verbal) primes in healthy volunteers (Kischka et al, 1996). These investigators argued that 'dopamine increases the signal-to-noise ratio in semantic networks by reducing the spread of semantic processing, thereby leading to a focusing of activation' (p 1107).…”

Section: Lexical Salience Task and Amph-induced Semantic Activationmentioning

confidence: 99%

Amphetamine Primes Motivation to Gamble and Gambling-Related Semantic Networks in Problem Gamblers

Zack

Poulos

2003

Neuropsychopharmacol

130

101

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Dopaminergic modulation of semantic network activation

Cited by 139 publications

References 43 publications

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Dynamics of the semantic priming shift: behavioral experiments and cortical network model

Amphetamine Primes Motivation to Gamble and Gambling-Related Semantic Networks in Problem Gamblers

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