Dopaminergic modulation of receptive fields in rat sensorimotor cortex

Hosp, Jonas A.; Hertler, Benjamin; Atiemo, Clement Osei; Luft, Andreas R.

doi:10.1016/j.neuroimage.2010.07.029

Cited by 22 publications

(20 citation statements)

References 54 publications

(63 reference statements)

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“…This effect in the 'on' state may result if DA has a net inhibitory influence on GABAergic interneurons that mediate the synchronous activity between minicolumns within SI. Recent evidence suggests that DA antagonists acting at D1 and D2-type receptors in SI in rats increased the amplitude of somatosensory evoked potentials and increase cortical excitability 29 . Data from the present study suggests that DA acts to increase SI excitability in PD, possibly via inhibition of local inhibitory interneurons between minicolumns.…”

Section: Discussionmentioning

confidence: 99%

Dopamine Alters Tactile Perception in Parkinson's Disease

Nelson

Premji²,

Rai³

et al. 2012

Can. J. Neurol. Sci.

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. Contexte : Le traitement anormal de l'information somatosensitive pourrait contribuer à l'altération de la motricité observée dans la maladie de Parkinson (MP). Il a été démontré que les médicaments dopaminergiques modifient le traitement de l'information somatosensitive de telle sorte que la perception tactile en est améliorée. Dans la MP, nous ne savons pas si la séquence temporelle des stimuli tactiles est modifiée et si les médicaments dopaminergiques modifient cette perception. Méthode : La perception tactile somatosensitive a été étudiée au moyen du test de discernement de l'ordre de succession de stimuli chez des patients atteints de la MP avec et sans effet de la médication dopaminergique et chez des témoins en bonne santé appariés pour l'âge. L'évaluation du discernement de l'ordre temporel de stimuli a été effectuée au moyen de la stimulation contrôlée par ordinateur des 2e et 3e doigts de la main droite. Les sujets devaient déterminer quel stimulus était appliqué le premier. Deux tâches expérimentales ont été comparées : le discernement de l'ordre temporel sans et avec synchronisation, soit l'application au préalable d'une vibration synchrone aux les 2e et 3e doigts. Résultats : Le discernement de l'ordre temporel chez les patients atteints de la MP sans et avec l'effet des médicaments était semblable à celui des témoins. Lorsque le test de discernement de l'ordre temporel était précédé par les vibrations synchrones, l'acuité tactile chez les témoins et les patients sans l'effet de la médication était perturbée à des degrés semblables, mais cette perturbation perceptuelle due aux vibrations synchrones n'était pas présente chez les patients sous l'effet de la médication. Conclusions : Ces constatations suggèrent que, chez les patients atteints de la MP, la dopamine diminue la connectivité cortico-corticale dans l'aire somatosensitive SI, ce qui provoque des changements dans la sensibilité tactile.

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Section: Discussionmentioning

confidence: 99%

Dopamine Alters Tactile Perception in Parkinson's Disease

Nelson

Premji²,

Rai³

et al. 2012

Can. J. Neurol. Sci.

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“…53 Conversely, DA antagonists increase the excitability of somatosensory cortex to afferent signals. 53 Dopaminergic modulation may thus render somatosensory cortex circuitry more effective in processing sensory information from different sources. Our data suggest that ictogenesis is likely to be associated with a cyclic and transitory disruption in DA modulation in an abnormally oscillating network.…”

Section: Dopaminergic Influence On Comorbidities and Absencesmentioning

confidence: 99%

Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis

et al. 2019

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Objective In Genetic Absence Epilepsy Rats From Strasbourg (GAERSs), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified. Here, we addressed the involvement of the dopaminergic system in epilepsy onset in GAERSs. Methods Experiments were performed using rats at different stages of brain maturation from three strains according to their increasing propensity to develop absence seizures: nonepileptic control rats (NECs), Wistar Hannover rats, and GAERSs. Changes in dopaminergic neurotransmission were investigated using different behavioral and neurochemical approaches: autoradiography of D3R and dopamine transporter, single photon emission computed tomographic imaging, acute and chronic drug effects on seizure recordings (dopaminergic agonists and antagonists), quinpirole‐induced yawns and dopamine synaptosomal uptake, microdialysis, brain tissue monoamines, and brain‐derived neurotrophic factor quantification. Results Autoradiography revealed an increased expression of D3R in 14‐day‐old GAERSs, before absence seizure onset, that persists in adulthood, as compared to age‐matched NECs. This was confirmed by increased yawns, a marker of D3R activity, and increased seizures when animals were injected with quinpirole at low doses to activate D3R. We also observed a concomitant increase in the expression and activity of the dopamine transporter in GAERSs before seizure onset, consistent with both lowered dopamine basal level and increased phasic responses. Significance Our data show that the dopaminergic system is persistently altered in GAERSs, which may contribute not only to behavioral comorbidities but also as an etiopathogenic factor in the development of epilepsy. The data suggest that an imbalanced dopaminergic tone may contribute to absence epilepsy development and seizure onset, as its reversion by a chronic treatment with a dopamine stabilizer significantly suppressed epileptogenesis. Our data suggest a potential new target for antiepileptic therapies and/or improvement of quality of life of epileptic patients.

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“…Thus, a close and precise interaction between M1 and S1 is a prerequisite for successful motor learning (28). In S1, intra-cortical injection of both, D1- and D2-receptor antagonists induced an enlargement of somatosensory evoked potential (SEP)-amplitude consistent with an increased cortical excitability (30). Thus, by reducing S1 excitability, DA may serve focusing on relevant (= strong) somatosensory input thereby improving signal-to-noise ratio (31) and improving sensory discrimination (32).…”

Section: How Da May Promote Plasticity In M1mentioning

confidence: 99%

Dopaminergic Meso-Cortical Projections to M1: Role in Motor Learning and Motor Cortex Plasticity

Hosp¹,

Luft²

2013

Front. Neurol.

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103

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Although the architecture of a dopaminergic (DA) system within the primary motor cortex (M1) was well characterized anatomically, its functional significance remained obscure for a long time. Recent studies in rats revealed that the integrity of DA fibers in M1 is a prerequisite for successful acquisition of motor skills. This essential contribution of DA for motor learning is plausible as it modulates M1 circuitry at multiple levels thereby promoting plastic changes that are required for information storage: at the network level, DA increases cortical excitability and enhances the stability of motor maps. At the cellular level, DA induces the expression of learning-related genes via the transcription factor c-Fos. At the level of synapses, DA is required for the formation of long-term potentiation, a mechanism that likely is a fingerprint of a motor memory trace within M1. DA fibers innervating M1 originate within the midbrain, precisely the ventral tegmental area (VTA) and the medial portion of substantia nigra (SN). Thus, they could be part of the meso-cortico-limbic pathway – a network that provides information about saliency and motivational value of an external stimulus and is commonly referred as “reward system.” However, the behavioral triggers of the release of dopamine in M1 are not yet identified. As alterations in DA transmission within M1 occur under various pathological conditions such as Parkinson disease or ischemic and traumatic brain injury, a deeper understanding of the interaction of VTA/SN and M1 may reveal a deeper insight into a large spectrum of neurological disorders.

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Dopaminergic modulation of receptive fields in rat sensorimotor cortex

Cited by 22 publications

References 54 publications

Dopamine Alters Tactile Perception in Parkinson's Disease

Dopamine Alters Tactile Perception in Parkinson's Disease

Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis

Dopaminergic Meso-Cortical Projections to M1: Role in Motor Learning and Motor Cortex Plasticity

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