Dopaminergic Compounds in Vitex Agnus Castus

Wuttke, W.; Gorkow, C.; Jarry, H.

doi:10.1007/978-3-642-85434-7_6

Cited by 35 publications

(21 citation statements)

References 7 publications

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“…Dopaminergic effects of the VAC BNO 1095 extract have been proven in animal and clinical trials. 10,11 Vitex agnus castus extract has been used in several placebo-controlled trials. [12][13][14][15][16] These studies confirmed that VAC relieves symptoms of the PMS without notable side effects.…”

Section: Introductionmentioning

confidence: 99%

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Lin

Chen

et al. 2010

Aust NZ J Obst Gynaeco

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Section: Introductionmentioning

confidence: 99%

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Lin

Chen

et al. 2010

Aust NZ J Obst Gynaeco

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“…Wa È hrend in den ersten Jahren der Erforschung des Wirkprinzips von Agnus castus in phytotherapeutischer Dosierung eine Follikelstimulierendes-Hormon(FSH)-supprimierende und LH-sowie Prolaktin-stimulierende Wirkung postuliert worden waren, konnte in spa Èteren Studien nachgewiesen werden, dass Agnus castus aus mindestens 3 Einzelsubstanzen besteht [32], welche einen dopaminergen Wirkmechanismus besitzen. Die Substanzen greifen am D2-Rezeptor an und bewirken eine Senkung der Prolaktin-Konzentration [21,22,41,42,45,47]. Die Senkung der Prolaktin-Konzentration fu È hrt wiederum zu einer Erho È hung der pulsatilen Sekretion von GnRh und dadurch zu einer Normalisierung von LH/ FSH.…”

Section: Discussionunclassified

Die Wirksamkeit des Komplexmittels Phyto-Hypophyson<sup>®</sup> L bei weiblicher, hormonell bedingter Sterilität. Eine randomisierte, placebokontrollierte, klinische Doppelblindstudie

Bergmann

Luft²,

Boehmann³

et al. 2000

Complement Med Res

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Phyto-Hypophyson^(r) L for Female Infertility. Randomized, Placebo-Controlled, Clinical Double-Blind Study Objective and Design:In a prospective, randomized, placebo-controlled, double-blind study, the effects of Phyto Hypophyson L (Steierl-Pharma GmbH, Herrsching, Germany), an Agnus castus-containing homeopathic preparation, were investigated in 67 women with fertility disorders. Patients and Methods:37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L or placebo 3 times a day over 3 months or 3 cycles. Outcome Measure and Results:The outcome measure being spontaneous menstruation, improved concentration of progesterone in the luteal phase, shortening of the cycle, earlier ovulation, and pregnancy was achieved in 38 out of 67 women. It was achieved more often from women with oligomenorrhea in the Phyto Hypophyson L group compared to the placebo group (82 versus 45%, p = 0.021). However, there was no significant effect when viewing the whole group. The baby take-home rate during the therapy and 6 months after the end of the therapy showed a ratio of 6 : 2 (18.7 : 6.4%). This result was not significant. Furthermore, in the oligomenorrhea verum group we observed a significant increase of progesterone during the luteal phase compared to the oligomenorrhea placebo group. Only very few undesirable drug effects were observed. Conclusion: In women with sterility and oligomenorrhea, a treatment with Phyto Hypophyson L can be recommended over a period of 3–6 months.

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“…В последнее время после изучения фармакологических свойств экстрактов Agnus castus стало возможным их широкое применение [24,26,27] (в экспери ментах in vitro показано, что экстракты Agnus castus обладают высоким сродством к D2 дофаминовым рецепторам) [25,26,28,[29][30][31][33][34][35][36]. У пяти выделенных из бициклических дитерпенов веществ определены допаминер гическая активность и селективное сродство к эстрогеновым рецепторам.…”

Section: обзор литературных данныхunclassified

“…Среди которых заслуженное место занимают Циклодинон и Мастодинон (Бионорика СЕ). В литературных источниках представлено достаточное количество де тальных исследований действия препара тов на основе Vitex agnus castus: эффектив ное использование для лечения латентной гиперпролактинемии и мастодинии, пред менструального и климактерического синд ромов [39,[42][43][44][45][46].…”

Section: обзор литературных данныхunclassified

Mastodynia elimination at hormonal treatment of patients with uterine myoma

Тихомиров¹,

Леденкова²

2014

Reproductive Endocrinology

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Dopaminergic Compounds in Vitex Agnus Castus

Cited by 35 publications

References 7 publications

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Die Wirksamkeit des Komplexmittels Phyto-Hypophyson<sup>®</sup> L bei weiblicher, hormonell bedingter Sterilität. Eine randomisierte, placebokontrollierte, klinische Doppelblindstudie

Mastodynia elimination at hormonal treatment of patients with uterine myoma

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