Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Ma, Linlin; Lin, Shunquan; Chen, Rong; Zhang, Ying; Chen, Fengling; Wang, Xiuli

doi:10.1111/j.1479-828x.2010.01137.x

Cited by 21 publications

(23 citation statements)

References 14 publications

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“…The same results were observed in what appears to be a subset of these women at a hospital in Beijing for total PMS symptoms on PMTS and PMSD, and for negative affect and water retention (all p < 0.05) but not pain or food cravings [28]. However, on the individual symptoms, 16 of 17 (all except pain) showed superiority over placebo (p < 0.001) in this same cohort [29]. Improvement was greater with the Vitex extract (4.3-4.8 mg/day dried extract, Isfahan Gol Daroo) than with placebo for total PMS symptoms measured on the DSR over 2 cycles, and for psychological and physical domains (both p < 0.001) but not symptoms of "suicide" or swelling of extremities [34].…”

Section: Pms: Vitex Versus Placebosupporting

confidence: 73%

“…1). However, two articles were based on the same data [28,29]. In this case, both papers were examined to extract all relevant information.…”

Section: Discussionmentioning

confidence: 99%

“…In PMS, all studies, with the exception of one poor quality trial [24], showed Vitex extracts to be superior to placebo [22,23,28,29,31,34], pyridoxine (vitamin B6) [33], and magnesium [35] for the amelioration of total PMS symptoms, and psychological and physical subclusters. Findings regarding premenstrual bloating [23], fluid retention [22,28], swelling of extremities [34], and food cravings [29,36] appear to be inconsistent, however. In PMDD, fluoxetine outperformed Vitex in two studies [21,36], although improvements were also evident with Vitex, which was associated with fewer adverse events.…”

Section: ✓ (Partial)mentioning

confidence: 99%

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Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials

Die

Burger²,

Teede

et al. 2012

Planta Med

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Introduction !Use of complementary medicines is becoming increasingly prevalent in Western cultures, with women constituting the largest user group [1]. Treatments for female reproductive health are often sought [2,3]. In this context, the phytotherapeutic agent Vitex agnus-castus fruit (chaste tree, chasteberry; family: Verbenaceae) is commonly employed for a range of female reproductive disorders [4], including premenstrual syndrome (PMS) and associated cyclic mastalgia, premenstrual dysphoric disorder (PMDD), lactation difficulties, low fertility [5], and menopause-related complaints [4, 6]. PMS affects up to 40 % women [7,8], with a further 3-8% (or even 13-18 %) qualifying for the diagnosis of the more severe PMDD [9,10]. Cyclical breast symptoms are experienced by approximately 70% of women, while 22% experience moderate-to-extreme discomfort classified as cyclical mastalgia [11]. All of these common problems can be severe enough to interfere with usual activities. Conventional treatments such as hormonal interventions and synthetic antidepressant agents are not preferred options for a number of women. In this context, women often turn Abstract ! Vitex agnus-castus L. (chaste tree; chasteberry) is a popular herbal treatment, predominantly used for a range of female reproductive conditions in Anglo-American and European practice. The objective of this systematic review was to evaluate the evidence for the efficacy and safety of Vitex extracts from randomised, controlled trials investigating womenʼs health. Eight databases were searched using Latin and common names for Vitex and phytotherapeutic preparations of the herb as a sole agent, together with filters for randomised, controlled trials or clinical trials. Methodological quality was assessed according to the Cochrane risk of bias and Jadad scales, as well as the proposed elaboration of CONSORT for reporting trials on herbal interventions. Thirteen randomised, controlled trials were identified and twelve are included in this review, of which eight investigated premenstrual syndrome, two premenstrual dysphoric disorder, and two latent hyperprolactinaemia. For premenstrual syndrome, seven of eight trials found Vitex extracts to be superior to placebo (5 of 6 studies), pyridoxine (1), and magnesium oxide (1). In premenstrual dysphoric disorder, one study reported Vitex to be equivalent to fluoxetine, while in the other, fluoxetine outperformed Vitex. In latent hyperprolactinaemia, one trial reported it to be superior to placebo for reducing TRH-stimulated prolactin secretion, normalising a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels, while the other found Vitex comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia. Adverse events with Vitex were mild and generally infrequent. The methodological quality of the included studies varied, but was generally moderate-to-high. Limitations include small sample sizes in some studies, heterogeneity of conditions being treated, and a r...

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Section: Pms: Vitex Versus Placebosupporting

confidence: 73%

“…1). However, two articles were based on the same data [28,29]. In this case, both papers were examined to extract all relevant information.…”

Section: Discussionmentioning

confidence: 99%

Section: ✓ (Partial)mentioning

confidence: 99%

See 1 more Smart Citation

Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials

Die

Burger²,

Teede

et al. 2012

Planta Med

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“…It includes total dosage per day, number of times the herbs were taken per day dither at all phases or only during luteal phase (@ LP), the duration of the studies by menstrual cycles, sample size (Treatment Group: TG), two menstrual cycles of prospective ratings, baseline score using assessment tools used at each studies, the outcome measures and results, control types with number of analyzed: CG), and p-value.*M, Measurement; PMSD, Premenstrual Syndrome Diary (four-point rating scale); PMTS, The Premenstrual Tension Syndrome Self-Rating Scale; DSR, Daily Symptom Report; PAF, Premenstrual Assessment Form;HDRS, Hamilton Depression Rating Scale (17-item); MD, Menstrual Diary(made up of 25 symptoms); MDQ, menstrual distress questionnaire); BDI, Beck Depression Inventory; ANX, state-anxiety; ANG, state-anger(ANX, ANG were measured with the Spielberger State Trait Personality Inventory; PSS, perceived stress scale; STAI.**Study 10 [17] is the analysis of a sub-population of Study11 [18]. Study 12 is the analysis of a sub-population of a study within a systematic review of clinical trials [27].…”

Section: Resultsmentioning

confidence: 99%

Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disorder: systematic review

Jang

Kim

Choi

2014

BMC Complement Altern Med

109

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BackgroundDuring their reproductive years about 10% of women experience some kind of symptoms before menstruation (PMS) in a degree that affects their quality of life (QOL). Acupuncture and herbal medicine has been a recent favorable therapeutic approach. Thus we aimed to review the effects of acupuncture and herbal medicine in the past decade as a preceding research in order to further investigate the most effective Korean Medicine treatment for PMS/PMDD.MethodsA systematic literature search was conducted using electronic databases on studies published between 2002 and 2012. Our review included randomized controlled clinical trials (RCTs) of acupuncture and herbal medicine for PMS/PMDD. Interventions include acupuncture or herbal medicine. Clinical information including statistical tests was extracted from the articles and summarized in tabular form or in the text. Study outcomes were presented as the rate of improvement (%) and/or end-of-treatment scores.ResultsThe search yielded 19 studies. In screening the RCTs, 8 studies in acupuncture and 11 studies in herbal medicine that matched the criteria were identified. Different acupuncture techniques including traditional acupuncture, hand acupuncture and moxibustion, and traditional acupuncture technique with auricular points, have been selected for analysis. In herbal medicine, studies on Vitex Agnus castus, Hypericum perforatum, Xiao yao san, Elsholtzia splendens, Cirsium japonicum, and Gingko biloba L. were identified. Experimental groups with Acupuncture and herbal medicine treatment (all herbal medicine except Cirsium japonicum) had significantly improved results regarding PMS/PMDD.ConclusionsLimited evidence supports the efficacy of alternative medicinal interventions such as acupuncture and herbal medicine in controlling premenstrual syndrome and premenstrual dysphoric disorder. Acupuncture and herbal medicine treatments for premenstrual syndrome and premenstrual dysphoric disorder showed a 50% or better reduction of symptoms compared to the initial state. In both acupuncture and herbal medical interventions, there have been no serious adverse events reported, proving the safety of the interventions while most of the interventions provided over 50% relief of symptoms associated with PMS/PMDD. Stricter diagnostic criteria may have excluded many participants from some studies. Also, depending on the severity of symptoms, the rate of improvement in the outcomes of the studies may have greatly differed.

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“…VAC, PMS'de oldukça fazla çalışıl-mıştır. Plasebo ile etkinliğinin karşılaştırıldığı çalışmalarda özel-likle sıvı tutulumuna bağlı semptomlarda ve PMS negatif semptomlarında anlamlı düzelme saptanmıştır [21][22][23]. Çalışmamız-da PMS semptomlarında literatürle uyumlu olarak tedavi sonrası VAS değerlerinde ağlama atakları dışında önemli düzelmeler saptanmıştır.…”

Section: İstatistiksel Analizunclassified

Ethinyl Estradiol-Drospirenon Versus Vitex Agnus-Castus Extract in Efficacy of the Treatment of Premenstrual Syndrome

2016

Ann Clin Anal Med

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Evaluating therapeutic effect in symptoms of moderate‐to‐severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women

Abstract: Vitex agnus castus is more effective than placebo in the treatment of moderate-to-severe PMS in Chinese women, especially in symptoms of negative effect and insomnia.

Cited by 21 publications

References 14 publications

Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials

Vitex agnus-castus Extracts for Female Reproductive Disorders: A Systematic Review of Clinical Trials

Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disorder: systematic review

Ethinyl Estradiol-Drospirenon Versus Vitex Agnus-Castus Extract in Efficacy of the Treatment of Premenstrual Syndrome

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