Dopamine transporter development in postnatal rat striatum: an autoradiographic study with [3H]WIN 35,428

Coulter, Cynthia L.; Happe, H. Kevin; Murrin, L. Charles

doi:10.1016/s0165-3806(97)00135-1

Cited by 31 publications

(17 citation statements)

References 38 publications

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“…Moreover, dopamine transporter (a primary site of action of cocaine) expression can increase with age (Coulter et al 1997;Tarazi et al 1998) with the most significant increases occurring during adolescence. Adolescent and adult female rats also differ in circulating concentrations of gonadal hormones; fluctuations in estradiol and progesterone that occur through the estrous cycle of female rats (Butcher et al 1974;Smith et al 1975) might impact the pharmacokinetic profile of cocaine, although studies exploring this possibility have yielded inconsistent results (Chin et al 2002;Bowman et al 1999;Festa et al 2004;Niyomchai et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

et al. 2012

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“…Striatal DA receptor densities peak at PND 40 then decrease to adult levels [3,73]. DAT expression in NAcc and striatum increases with age, peaking at PND 60 [17,72]. Due to increasing numbers of DATs during adolescence, higher reuptake decreases basal DA in the striatum [2] and the NAcc [56] and upregulates cyclic-AMP signaling [1].…”

Section: Discussionmentioning

confidence: 99%

“…However, animal studies revealed that DAT expression in NAcc and striatum increases with age peaking around PND 60 [17,72]. It is clear that significant developmental changes occur during the adolescent period, however, it is presently unknown how drugs of abuse, specially cocaine, a DAT inhibitor, alter this neurodevelopment.…”

Section: Introductionmentioning

confidence: 99%

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Catlow

Kirstein

2007

Neurotoxicology and Teratology

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The use of cocaine during adolescent development could alter the normal growth of brain regions affected by cocaine, specifically the reward system, and impact the adult mesolimbic system. However, there is scant literature aimed at determining whether animals are more vulnerable to the adverse effects of drugs during adolescence. The present study investigated whether cocaine pretreatment in either adolescence or adulthood altered the dopaminergic response to a naturally reinforcing substance in adulthood. To evaluate the responsivity of the mesolimbic system after repeated cocaine, sucrose was offered during the dialysis procedure and dialysates were collected. Regardless of age all saline pretreated rats had significant increases in sucrose-induced extracellular dopamine (DA) levels in the nucleus accumbens septi (NAcc) as compared to baseline levels. Rats pretreated with cocaine as adults also had significant increases in DA levels after sucrose. Interestingly, sucrose intake significantly enhanced DA levels in cocaine pretreated adolescent rats as compared to all other conditions. The results from the present study show that in rats pretreated with cocaine during adolescence there is an enhanced response of the dopaminergic system in animals exposed to a naturally reinforcing substance. Therefore, cocaine exposure during adolescence results in long-term functional changes in the mesolimbic pathway. Future studies need to ascertain the underlying mechanisms and their potential role in cocaine addiction.

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“…It has been reported that DA transporter (DAT) expression is highest during adolescence in human striatum (Meng et al, 1999). However, animal studies revealed that DAT expression in nucleus accumbens septi (NAcc) and striatum increases with age peaking at PND 60 (Coulter et al, 1997;Tarazi et al, 1998). Interestingly, the most rapid increase in DAT occurs during adolescence (Coulter et al, 1997;Tarazi et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…However, animal studies revealed that DAT expression in nucleus accumbens septi (NAcc) and striatum increases with age peaking at PND 60 (Coulter et al, 1997;Tarazi et al, 1998). Interestingly, the most rapid increase in DAT occurs during adolescence (Coulter et al, 1997;Tarazi et al, 1998). It is well known that drugs of abuse have a direct effect on the dopaminergic system (Koob and Nestler, 1997).…”

Section: Introductionmentioning

confidence: 99%

Heightened cocaine-induced locomotor activity in adolescent compared to adult female rats

Catlow

Kirstein

2005

J Psychopharmacol

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Initiation and experimentation with illicit drugs often occurs in adolescence. Evidence suggests that adolescent rats are more sensitive to some of the effects of drugs of abuse than adult rats. The present study investigated whether adolescent and adult female Sprague Dawley rats differ in cocaine-induced locomotor activity. Animals were placed in the test environment for 30 minutes, and then administered an intraperitoneal (IP) injection of either cocaine (20mg/kg) or saline (0.9%). Both adult and adolescent animals showed significant increases in locomotor activity as a result of cocaine administration compared to saline controls. Interestingly, cocaine induced significantly more locomotor activity in the adolescent females compared to the adults, demonstrating that cocaine acts differently in developing animals.

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Dopamine transporter development in postnatal rat striatum: an autoradiographic study with [3H]WIN 35,428

Cited by 31 publications

References 38 publications

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Heightened cocaine-induced locomotor activity in adolescent compared to adult female rats

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