Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

Baladi, Michelle G.; Koek, Wouter; Aumann, Megan; Velasco, Fortino

doi:10.1007/s00213-012-2663-7

Cited by 32 publications

(50 citation statements)

References 63 publications

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“…These behavioral responses are mediated in part by dopamine- and glutamate-mediated transmission in MSNs of the NAc core (Balleine 2005; Cardinal et al 2002; Crombag et al 2008a; Crombag et al 2008b; Kelley 2004; Setlow et al 2002). In addition, consumption of sugary, fatty foods and obesity are associated with changes in mesolimbic function (Baladi et al 2012; Hryhorczuk et al 2015; McGuire et al 2011; Rada et al 2010). Here, we first examined the induction and expression of cocaine-induced locomotor sensitization in outbred rats identified as susceptible or resistant to weight gain when given free access to junk-food.…”

Section: Discussionmentioning

confidence: 99%

“…Although the effect of eating sugary, fatty, foods on the acute locomotor-activating effects of amphetamines has been examined (Baladi et al 2012; McGuire et al 2011), potential differences in the induction and expression of sensitization in obesity-susceptible populations has not. It is well established that only a sub-set of rats will become obese when given free access to a moderately fatty diet (Levin et al 1997; Robinson et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, locomotor sensitization is also associated with enhanced motivational responses to food cues that can contribute to the pursuit of food rewards (Wyvell and Berridge 2000; 2001). Although several studies have examined the effect of eating sugary, fatty, foods on the acute locomotor-activating effects of amphetamines (Baladi et al 2012; McGuire et al 2011), none have examined the subsequent expression of sensitization after a drug-free period or potential differences in the induction vs. expression of sensitization in obesity-susceptible populations. This is important because interactions between the development of obesity and/or ingestion of high fat foods may produce different neurobehavioral alterations in obesity susceptible vs. resistant populations (Jensen and Kirwan 2015; Levin et al 1997; Murdaugh et al 2012; Yokum et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity

et al. 2015

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Rationale Basal and diet-induced differences in mesolimbic function, particularly within the nucleus accumbens (NAc), may contribute to human obesity; these differences may be more pronounced in susceptible populations. Objectives We determined whether there are differences in cocaine-induced behavioral plasticity in rats that are susceptible vs. resistant to diet-induced obesity, and basal differences in the striatal neuron function in adult and adolescent obesity-prone and obesity-resistant rats. Methods Susceptible and resistant outbred rats were identified based on “junk-food” diet-induced obesity. Then, the induction and expression of cocaine-induced locomotor sensitization, which is mediated by enhanced striatal function and is associated with increased motivation for rewards and reward-paired cues, were evaluated. Basal differences in mesolimbic function were examined in selectively bred obesity-prone and obesity-resistant rats (P70-80 and P30-40) using both cocaine induced locomotion and whole-cell patch clamping approaches in NAc core medium spiny neurons (MSNs). Results In rats that became obese after eating “junk-food”, the expression of locomotor sensitization was enhanced compared to non-obese rats, with similarly strong responses to 7.5 and 15 mg/kg cocaine. Without diet manipulation, obesity-prone rats were hyper-responsive to the acute locomotor-activating effects of cocaine, and the intrinsic excitability of NAc core MSNs was enhanced by ~60% at positive and negative potentials. These differences were present in adult, but not adolescent rats. Post-synaptic glutamatergic transmission was similar between groups. Conclusions Mesolimbic systems, particularly NAc MSNs, are hyper-responsive in obesity-prone individuals; and interactions between predisposition and experience influence neurobehavioral plasticity in ways that may promote weight gain and hamper weight loss in susceptible rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity

et al. 2015

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“…In order to assess the development of locomotor sensitization across Cocaine Tests #1–4, measures of potency (ED 50 ), effectiveness (E max ), and area under the cocaine dose-response curve (AUC) were compared using one-way repeated-measures ANOVAs with post-hoc Dunnett’s tests (within sex and diet), and by two-way repeated-measures ANOVAs with post-hoc Holm-Sidak’s tests (across sex and diet). AUC calculations provide a composite measure of the magnitude of sensitization (i.e., accounts for changes in both ED 50 and E max ) and facilitated historical comparisons with data from this laboratory on the impact of consuming high-fat chow on cocaine-induced locomotor activity in rats (Baladi, Koek, Aumann, Velasco, & France, 2012). In order to determine if locomotor responses changed following 4 weeks without cocaine, log ED 50 , E max , and AUC values for Cocaine Tests #4 and 5 were compared using paired, two-tailed t-tests.…”

Section: Methodsmentioning

confidence: 99%

Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice.

Collins

Chen

Tschumi

et al. 2015

Experimental and Clinical Psychopharmacology

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Drug abuse and obesity are serious public health problems. Dopamine plays a central role in mediating the reinforcing effects of drugs and food. Prolonged use of drugs is known to alter the function and/or sensitivity of many neurotransmitter systems, including dopamine, however, the impact of consuming foods high in fat and/or sugar is less clear. These studies characterized the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice consuming one of four diets: (1) standard chow + water; (2) standard chow + 10% sucrose solution; (3) high-fat chow + water; or (4) high-fat chow + 10% sucrose solution. The acute locomotor effects of cocaine (3.2–32.0 mg/kg) were evaluated four weeks after initiating dietary conditions; the effects of repeated cocaine administration were evaluated after 5, 6, 7, and 12 weeks. During acute tests, mice consuming a diet high in fat and/or sucrose exhibited greater locomotor responses to cocaine than mice consuming standard chow and water, regardless of sex. Although diet-induced enhancements persisted across repeated cocaine testing, locomotor sensitization developed more rapidly in females drinking sucrose (and consuming either standard or high-fat chow) than in females consuming standard chow and water. In addition to providing evidence that consuming a diet high in fat and/or sugar enhances abuse-related effects of cocaine in ways that might increase vulnerability to abuse cocaine, these studies identified a potentially important sex-related difference in the interaction between nutrition and cocaine effects, with the impacts of sucrose consumption being greater in females than in males.

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“…Moreover, a recent series of studies suggest that factors such as drug history, sex, and feeding condition (i.e., the amount and type of food eaten) can alter the relative contribution of particular dopamine receptor subtypes to the behavioral effects of direct- (e.g., quinpirole) and indirect-acting (e.g., cocaine) dopamine receptor agonists (Baladi and France 2010; Baladi et al 2010; 2011; 2012; 2013; Collins et al 2008). For example, the discriminative stimulus effects of quinpirole (a direct-acting dopamine D 2 -like receptor agonist) and cocaine are primarily mediated by dopamine D 2 receptors in food-restricted rats, whereas dopamine D 3 receptors play a larger role in mediating these same effects in rats that have free access to food (Baladi et al 2010; 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of dopamine D2-like receptor agonists in mice trained to discriminate cocaine from saline: Influence of feeding condition

Collins¹,

Jackson²,

Koek³

et al. 2014

European Journal of Pharmacology

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In rats, the discriminative stimulus effects of direct- and indirect-acting dopamine receptor agonists are mediated by multiple dopamine receptor subtypes and the relative contribution of dopamine D2 and D3 receptors to these effects varies as a function of feeding condition. In these studies, free-fed and food-restricted mice were trained to discriminate 10.0 mg/kg cocaine using a two-lever discrimination procedure in which responding was maintained by food. Both groups of mice acquired the discrimination; however, free-fed mice responded at lower rates than food-restricted mice. Dopamine D3 receptor agonists, pramipexole and quinpirole, increased cocaine-appropriate responding (>85%) in food-restricted, but not in free-fed mice. The dopamine D2 receptor agonist, sumanirole, and the nonselective dopamine receptor agonist, apomorphine, failed to increase cocaine-appropriate responding in either group. Free-fed mice were more sensitive than food-restricted mice to the rate-decreasing effects of dopamine receptor agonists and these effects could not be overcome by increasing the magnitude of reinforcement. Because feeding condition did not alter quinpirole-induced hypothermia, it is unlikely that differences in the discriminative stimulus or rate-decreasing effects of dopamine D2-like receptor agonists were due to differences in the pharmacokinetic properties of the drugs. Although these results suggest that the discriminative stimulus effects of cocaine are mediated by both dopamine D2 and D3 receptors in food-restricted mice, the increased sensitivity of free-fed mice to the rate-decreasing effects of dopamine D2-like receptor agonists limited conclusions about the impact of feeding conditions on the relative contribution of dopamine D2 and D3 receptors to the discriminative stimulus effects of cocaine.

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Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

Cited by 32 publications

References 63 publications

Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity

Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity

Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice.

Effects of dopamine D2-like receptor agonists in mice trained to discriminate cocaine from saline: Influence of feeding condition

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