Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders

Groleau, Patricia; Steiger, Howard; Joober, Ridha; Bruce, Kenneth R.; Israël, Mimi; Badawi, Ghislaine; Zeramdini, Nadia; Sycz, Lindsay

doi:10.1016/j.jpsychires.2012.05.018

Cited by 34 publications

(15 citation statements)

References 73 publications

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“…These findings corroborate the growing evidence about the role of COMT on ED. Moreover, these results are in line with several studies that pointed out the high-activity allele of COMT, Val158, as risk factor for BN [1,11,12]. However, as mentioned before, some studies also showed an association between the low activity allele of COMT, Met158 and ED, whereas other studies found no association.…”

Section: Discussionsupporting

confidence: 91%

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Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders

et al. 2015

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Patients with BN and BED presented higher S-COMT activity in erythrocytes, which is in agreement with previous studies on the literature addressing the high-activity COMT allele, Val158, as risk factor for eating disorders. Although in fluoxetine-treated patients with BN the activity of S-COMT was similar to the controls, this is not explained by a direct interaction between fluoxetine and S-COMT as verified in in vitro assays.

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Section: Discussionsupporting

confidence: 91%

“…The results were controversial: some studies appointed the higher activity allele as risk factor for AN [9,10] or BN [1,11,12], whereas other group of studies pointed out the lower activity COMT allele [13,14]. Some studies did not find association between this polymorphism and AN [1,2,[15][16][17][18] and BN [10].…”

Section: Introductionmentioning

confidence: 99%

Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders

et al. 2015

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“…The pathology may be important in an appearance of bulimia. As shown [Groleau et al, 2012], genes acting within the dopamine system may contribute, either directly or indirectly (i.e. in interaction with traumatic childhood experiences), to variations in the presentation of comorbid traits and, possibly, of bulimic symptoms.…”

Section: Bulimia Nervosa -Bnmentioning

confidence: 97%

Eating Disorders: Problems of Contemporary Civilisation – A Review

Babicz-Zielińska¹,

Wądołowska²,

Tomaszewski³

2013

Pol. J. Food Nutr. Sci.

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(Prof. E. Babicz-Zielińska) trition…, 2003]. Obesity is a chronic non-infectious disease, which signifi cantly deteriorates the quality of life, shortens its length and constitutes a risk factor for many other metabolic diseases such as type 2 diabetes, cancer of uterus, colon and breast cancer, hypertensive disease, degenerative arthritis, stroke and coronary heart disease. The increase in relative body mass index (BMI) by a single unit increases the risk of diabetes by 20-50% and the risk of cancer by 3-10% [Comparative quantifi cation..., 2004].According to estimates by WHO experts in the world more than 1 billion people have an excessive body weight, i.e. more than 300 million are obese and more than 750 million have overweight [World health statistics, 2010]. The overweight affects more men, and obesity more women, therefore women may experience more negative effects of excessive body fat. In Poland, the excessive body weight is observed in 40% to 60% of adults, depending on a survey, including obesity typical of 15% to 20% of adults [Wądołowska, 2009]. The occurrence of excessive weight among children and adolescents does not exceed 15%.The eating disorders seem to be very likely the social problem, even if the data on the extent of the irregularity is fragmented. The eating disorders have morbidity and mortality rates that are among the highest of any mental disorders [Herpertz-Dahlmann et al., 2012]. It is estimated that in the U.S. The eating disorders have been reviewed based on state-of-art of contemporary psychology, medicine and nutrition science, with a special emphasis put on different symptoms and forms, origins and testing methods. Among promoting eating disorders, bulimia nervosa, binge eating disorder, night eating disorder, sleep-related eating disorder are among offi cially approved and investigated. Among disorders resulting from lack of acceptance of own appearance, anorexia nervosa and bigorexia nervosa are the most serious improper ones. Disorders arising from health care include orthorexia nervosa and recently pregorexia. Different origins of eating disorders are considered, divided into three groups: social, psychological and pathological. The desire to possess a slim shapely silhouette and young appearance, usually under pressure of a social group, may result in disorders such as anorexia nervosa, pregorexia, ageorexia, and bigorexia nervosa. On the other hand, the focusing on eating mainly the biologically pure food, being a purely psychological and individual problem, may be a source of orthorexia nervosa. Majority of disorders have a psychological background constituting the escape and an answer to everyday life problems diffi cult to overcome. Recently, pathology is often considered as an additional and important determinant, which may cause or enhance the appearance of binge eating or night eating disorder. The eating disorders, if not subject to proper therapy and advising, can tend to incline and develop. The further research in order to properly recognise the eating disorders,...

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“…Since both Met-and Val-homozygosity have been related to increased striatal DA activations to reward-feedback or reward-predictive cues (Yacubian et al, 2007;Dreher et al, 2009;Camara et al, 2010;Lancaster et al, 2012;Katz et al, 2014), immediate response bias/delay discounting (Boettiger et al, 2007;Paloyelis et al, 2010;Gianotti et al, 2012;Smith and Boettiger, 2012), impulsivity (Salo et al, 2010;Groleau et al, 2012;Varga et al, 2012;Malloy-Diniz et al, 2013;Soeiro-DeSouza et al, 2013;Guillot et al, 2014), and aggression (Rujescu et al, 2003;Caspi et al, 2008;Albaugh et al, 2010;Wagner et al, 2010;Brennan et al, 2011), the effect of COMT genotypes on disinhibitory traits is likely modulated by other factors such as tonic striatal DA activity and D2-receptor densities. For example, Reuter et al (2006) demonstrated that BAS scores correlate with the relative ratio between PFC DA activity as mediated by COMT and striatal DA activity/D2-receptor functioning as mediated by the TaqIA-ANKK1 SNP.…”

Section: Da Metabolization (Catechol-o-methyltransferase)mentioning

confidence: 99%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders

Cited by 34 publications

References 73 publications

Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders

Catechol-O-methyltransferase activity in erythrocytes from patients with eating disorders

Eating Disorders: Problems of Contemporary Civilisation – A Review

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

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