Dopamine Receptor Asymmetry in Schizophrenia

Reynolds, Gavin P.; Czudek, Carole; Bzowej, Natalie; Seeman, Philip

doi:10.1016/s0140-6736(87)90325-4

Cited by 49 publications

(12 citation statements)

References 5 publications

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“…For example, right sided dopaminergic hyperactivity would result in ipsilateral EPSE as the dose of antipsychotic medication required to return the right striatum to normal dopaminergic functioning would reduce left striatal dopaminergic function into the parkinsonian range. Several studies have also suggested the existence of an asymmetry of D 2 receptor density in schizophrenia (Reynolds et al 1987;Crawley et al 1986), although these seems unlikely to be the explanation for the findings in our study given the equality of radiotracer binding. It was surprising that the motor changes we found, in patients with low levels of D 2 occupancy, did not correlate with D 2 occupancy and this result is not consistent with a recently published study that found a correlation between D 2 occupancy and a measure of reduction in hand writing (Kuenstler et al 1999).…”

Section: Discussioncontrasting

confidence: 65%

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Fitzgerald¹,

Kapur

Caligiuri

et al. 2000

Neuropsychopharmacology

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Section: Discussioncontrasting

confidence: 65%

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Fitzgerald¹,

Kapur

Caligiuri

et al. 2000

Neuropsychopharmacology

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“…The elevated prevalence of minor physical anomalies and non-right-handedness may indicate aberrant CNS development in schizophrenia. Structural asymmetries have been Sperling/Martus/Barocka found in the brains of schizophrenic patients in the occipital [5] and temporal regions [6] and in the sylvian fissure [7]. Though many explanations for the anomalous patterns of lateralization in schizophrenia have been proposed, none have yet been validated.…”

Section: Introductionmentioning

confidence: 99%

Non-Right-Handedness and Obstetrical Complications in Paranoid Hallucinatory Schizophrenics

Sperling

Martus²,

Barocka³

1999

Psychopathology

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In previous studies a link between pregnancy complications, minor physical anomalies and non-right-handedness was described in schizophrenic patients. There is evidence of an anomaly in the lateralization process in schizophrenia. Many studies of handedness and schizophrenia have found that schizophrenic patients have an increased rate of non-right-handedness compared with normal subjects. The contemporary neurodevelopmental hypothesis of schizophrenia emerged from pathobiological findings. In addition there is evidence for early brain lesions and malformations in fetal brain development. Especially pregnancy and birth complications have been found to be a risk factor for the later development of schizophrenia. In this study we set out to test the possible association between diagnosis and handedness, diagnosis and risk factors, as well as gender and handedness for 60 patients (30 men, 30 women) and 60 controls. The percentage of non-right-handedness was significantly elevated in the patient group (p = 0.0025). In a gender-specific analysis this result could be confirmed only for male patients. Peri- and postnatal developmental risk factors were significantly elevated in schizophrenics compared with controls. The percentage of all risk factors in the male group of schizophrenic non-right-handers was significantly elevated compared with right-handed male schizophrenics.

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“…It is unclear which etiological factor would give rise to Go~ or Gila asymmetry in the hippocampus, putamen, and caudate head. From neurochemical studies, abnormal lateralization in neural transduction has been supposed to be linked to the pathophysiology of schizophrenia: (1) dopamine content is increased in the left amygdala (Reynolds, 1983), (2) dopamine D2 receptor density is accentuated in the right putamen (Reynolds et al, 1987), (3) glutamate receptors are decreased in the left hippocampus (Kerwin et al, 1988), (4) glutamate uptake sites in the temporal cortex are inversely related to dopamine content in the amygdala, on the left side (Deakin et al, 1989), and (5) [3H]cAMP binding sites which can label the regulatory subunit of cAMP-dependent protein kinase are increased and Gia and Goa subunits are decreased in the left temporal cortices (Nishino etal., 1993). Thus, direction of asymmetry in the observed neurotransmitter or neuromodulator levels differs with the area of the brain.…”

mentioning

confidence: 99%

Reduced concentrations of the ?-subunit of GTP-binding protein Go in schizophrenic brain

Okada

Tokumitsu

Takahashi

et al. 1994

J. Neural Transmission

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Concentrations of the alpha-subunits of GTP-binding protein, Go (Go alpha) and of Gi2 (Gi2 alpha) in 6 areas (the hippocampus, parahippocampus, putamen, caudate head, orbital frontal cortex, and lateral temporal cortex) of control and schizophrenic postmortem brains were investigated using the highly sensitive enzyme immunoassay method. There was a significant decrease in Go alpha in the hippocampus and caudate head of the right hemisphere in schizophrenic patients compared to controls; the ANOVA (a general linear model; SAS Type II) demonstrated a significant diagnosis x side interaction only in the hippocampus. In other areas of the brain, analysis by grouping under diagnosis, side, age, gender, and postmortem delay showed no significant deviations in Go alpha between controls and schizophrenics. The concentrations of Gi2 alpha did not differ significantly in any area. These findings contrasted with the results yielded by ADP-ribosylation, which showed decreased pertussis toxin ADP-ribosylated amounts in the hippocampus and putamen of the contralateral (left) hemisphere. Some abnormal receptor-Go or Gi 1 signalling in hippocampus, putamen or caudate head may be involved in the pathogenesis of schizophrenia.

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Dopamine Receptor Asymmetry in Schizophrenia

Cited by 49 publications

References 5 publications

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Non-Right-Handedness and Obstetrical Complications in Paranoid Hallucinatory Schizophrenics

Reduced concentrations of the ?-subunit of GTP-binding protein Go in schizophrenic brain

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