Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Fitzgerald, Paul B.; Kapur, Shitij; Caligiuri, Michael P.; Jones, Carl J.; Silvestri, S.; Remington, Gary; Zipursky, Robert B.

doi:10.1016/s0893-133x(99)00081-0

Cited by 4 publications

(1 citation statement)

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“…24 Een tweede studie vond deze samenhang niet, mogelijk vanwege het kleine aantal patiënten (n = 20) en de lage dosering antipsychotica die gebruikt werd; gemiddeld waren de dopaminereceptoren maar voor 66% bezet en dat is mogelijk te weinig om subtiele traagheid te veroorzaken. 25 omdat de patiënt er dan een ziekte bij gekregen heeft. Een variant, de tardieve dystonie, werd pas aan het eind van de jaren zeventig van de vorige eeuw beschreven en geeft in een ernstige vorm vaak veel lichamelijke beperkingen.…”

Section: Tardieve Bewegingsstoornissenunclassified

Bewegingsstoornissen bij psychosen : so what?

Harten¹

2010

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Section: Tardieve Bewegingsstoornissenunclassified

Bewegingsstoornissen bij psychosen : so what?

Harten¹

2010

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Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia

Yang

Yeh

Chiu

et al. 2004

Psychiatry Research: Neuroimaging

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Whitehorn

Kopala

2002

Annals of Clinical Psychiatry

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Neuromotor dysfunction, particularly extrapyramidal signs and symptoms (EPSS), plays an important role in the assessment and treatment of patients in the early stages of psychotic disorders such as schizophrenia. By blocking dopamine D2 receptors, antipsychotic medications can produce EPSS, including tardive dyskinesia. EPSS is also observed in a third or more of patients first presenting with a psychotic disorder, prior to initiation of antipsychotic pharmacotherapy. This suggests that abnormalities in neuromotor control may be an integral component of the brain mechanisms associated with psychosis. Atypical antipsychotic agents can alleviate psychosis without inducing EPSS. Preexisting EPSS may be corrected.

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Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

Abstract: Extrapyramidal side-effects (EPSE) of antipsychotic medication are related to the occupancy of dopamine

Cited by 4 publications

References 37 publications

Bewegingsstoornissen bij psychosen : so what?

Bewegingsstoornissen bij psychosen : so what?

Association between cognitive performance and striatal dopamine binding is higher in timing and motor tasks in patients with schizophrenia

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