Dopamine modulation of glutamate metabotropic receptors in conditioned reaction of sensory motor cortex neurons of the cat

Storozhuk, V. M.; Khorevin, V. I.; Rozumna, Nataliia M.; Villa, Alessandro E. P.; Tetko, Igor V.

doi:10.1016/j.neulet.2003.11.039

Cited by 4 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Manipulation of the balance between inhibition and excitation not only influences excitability and somatotopy (Jacobs and Donoghue, 1991) but may also affect movement latencies through desynchronization of intracortical signalling. Increased movement latencies have been described after blocking metabotropic glutamate receptors during a conditioned reaction in cats (Storozhuk et al, 2004). This effect was reversed by DA application.…”

Section: D2-receptor Mediated Increase In Movement Latenciesmentioning

confidence: 94%

Dopaminergic Modulation of Motor Maps in Rat Motor Cortex: An In Vivo Study

Hosp¹,

Molina-Luna²,

Hertler³

et al. 2009

Neuroscience

View full text Add to dashboard Cite

While the primary motor cortex (M1) is know to receive dopaminergic projections, the functional role of these projections is poorly characterized. Here, it is hypothesized that dopaminergic signals modulate M1 excitability and somatotopy, two features of the M1 network relevant for movement execution and learning. To test this hypothesis, movement responses evoked by electrical stimulation using an electrode grid implanted epidurally over the caudal motor cortex (M1) were assessed before and after an intracortical injection of D1- (R-(+),8-chloro,7-hydroxy,2,3,4,5,-tetra-hydro,3-methyl,5-phenyl,1-H,3-benzazepine maleate, SCH 23390) or D2-receptor (raclopride) antagonists into the M1 forelimb area of rats. Stimulation mapping of M1 was repeated after 24 h. D2-inhibition reduced the size of the forelimb representation by 68.5% (P<0.001). Movements thresholds, i.e., minimal currents required to induce movement responses increased by 37.5% (P<0.001), and latencies increased by 35.9% (P<0.01). Twenty-4 h after the injections these effects were reversed. No changes were observed with D1-antagonist or vehicle. By enhancing intracortical excitability and signal transduction, D2-mediated dopaminergic signaling may affect movement execution, e.g. by enabling task-related muscle activation synergies, and learning.

show abstract

Section: D2-receptor Mediated Increase In Movement Latenciesmentioning

confidence: 94%

Dopaminergic Modulation of Motor Maps in Rat Motor Cortex: An In Vivo Study

Hosp¹,

Molina-Luna²,

Hertler³

et al. 2009

Neuroscience

View full text Add to dashboard Cite

show abstract

“…Data on the actions of DA on M1 neurons are limited. DA applied into M1 of awake cats led to increased excitability during a conditioned placing response (Storozhuk et al, 2004). Similarly, in layer V of primate M1 DA augmented the spontaneous activity in approximately 40% of the DA‐responsive neurons (Sawaguchi et al, 1986).…”

Section: Dopaminergic Effects On Cortical Neurons and Networkmentioning

confidence: 99%

Dopaminergic signals in primary motor cortex

Luft

Schwarz

2009

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Brainstem monoamine areas such as the ventral tegmental area (VTA) send dopaminergic projections to the cerebral cortex that are widely distributed across different cortical regions. Whereas the projection to prefrontal areas (PFC) has been studied in detail, little is known about dopaminergic projections to primary motor cortex (M1). These projections have been anatomically characterized in rat and primate M1. Primates have even denser dopaminergic projections to M1 than rats. The physiological role, the effects of dopaminergic input on the activity of M1 circuits, and the behavioral function of this projection are unknown. This review explores the existing anatomical, electrophysiological and behavioral evidence on dopaminergic projections to M1 and speculates about its functional role. The projection may explain basic features of motor learning and memory phenomena. It is of clinical interest because of its potential for augmenting motor recovery after a brain lesion as well as for understanding the symptomatology of patients with Parkinson's disease. Therefore, targeted investigations are necessary.

show abstract

“…Ïðè çàñòîñóâàíí³ ³îíîôîðåòè÷íî¿ àïë³êàö³¿ äîôàì³íó îäí³ àâòîðè âñòàíîâèëè çá³ëüøåííÿ çáóäëèâîñò³ ê³ðêîâèõ ³ ñòð³àòíèõ íåéðîí³â [5], òîä³ ÿê ³íø³ àâòîðè äîâîäÿòü ïðîòèëåaeíå [19]. Öå ïîâÿçóþòü ç òèì, ùî äîôàì³í ìîaeå ä³ÿòè ÿê áåçïîñåðåäíüî íà ïåâíó êë³òèíó, òàê ³ îïîñåðåäêîâàíî íà ³íø³ íåðâîâ³ êë³òèíè, ïåðåâàaeíî ÷åðåç ÃÀÌÊ-åðã³÷í³ ãàëüì³âí³ íåéðîíè [9,19,25].…”

Section: îáãîâîðåííß ðåçóëüòàò²âunclassified

Effect of iontophoretically administered L-DOPA and ketamin on the impulse activity of the somatomotor cortex neurons during the conditioned placing movements

Khorievin¹

2010

Fiziol Zh

View full text Add to dashboard Cite

Dopamine modulation of glutamate metabotropic receptors in conditioned reaction of sensory motor cortex neurons of the cat

Cited by 4 publications

References 18 publications

Dopaminergic Modulation of Motor Maps in Rat Motor Cortex: An In Vivo Study

Dopaminergic Modulation of Motor Maps in Rat Motor Cortex: An In Vivo Study

Dopaminergic signals in primary motor cortex

Effect of iontophoretically administered L-DOPA and ketamin on the impulse activity of the somatomotor cortex neurons during the conditioned placing movements

Contact Info

Product

Resources

About