Dopamine Metabolism and Disposition in Schizophrenic Patients

Maas, James W.; Contreras, Salvador; Seleshi, Ermias; Bowden, Charles L.

doi:10.1001/archpsyc.1988.01800300049005

Cited by 79 publications

(29 citation statements)

References 44 publications

(1 reference statement)

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“…Samples were stored at Ϫ 80 Њ C until the time of the assay. Patients were not treated with debrisoquin, which has been shown to decrease the peripheral contribution to plasma HVA (Maas et al 1988(Maas et al , 1993Swann et al 1980;Davidson et al 1987a;Kopin et al 1988;Duncan et al 1993). However, the low-monoamine diet, minimization of physical activity, and fasting prior to the blood draw used in this study has been shown to reduce statistical effects on plasma HVA levels (Davidson et al 1987b).…”

Section: Blood Drawsmentioning

confidence: 94%

“…Davidson et al (1991b) observed no significant differences in baseline values of plasma HVA, but did observe a difference in change in plasma HVA from baseline in exacerbated patients, and a correlation between peak psychosis and peak plasma HVA during withdrawal. Studies of drugfree exacerbated patients have also reported positive associations between plasma HVA and positive symptoms (Maas et al 1988). Studies examining both metabolites have shown differing results.…”

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confidence: 99%

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Plasma Catecholamine Metabolites as Markers for Psychosis and Antipsychotic Response in Schizophrenia

Kelley

Yao

Kammen

1999

Neuropsychopharmacology

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The objective of this study was to determine the association between the patterns of change in the dopaminergic metabolite plasma homovanillic acid (HVA), the noradrenergic metabolite The action of antipsychotic drugs on the dopamine system have led to many examinations of dopaminergic metabolites as possible markers for psychosis and antipsychotic response. However, it has also become clear that the noradrenergic system has extensive interactions with the dopamine system, and may also play a role in schizophrenia (Antelman and Caggiula 1977;Hornykiewicz 1982;van Kammen and Kelley 1991), and may play a key role in psychotic relapse (Ko et al., 1988;van Kammen et al. 1989van Kammen et al. , 1994van Kammen et al. , 1996a. Interactions between the two systems have been well studied in the CSF and plasma of schizophrenic patients through their respective metabolites: the dopamine metabolite homovanillic acid (HVA) and the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG). Plasma HVA has been shown to reflect central or brain dopamine activity through studies in animals and humans (Bacopoulos et al. 1979;Kendler et al. 1982;Maas et al. 1993;Lambert et al. 1993;Amin et al. 1992), indicating that 11-35% of plasma HVA comes from the brain.Several studies of schizophrenia have noted that the behavioral response to antipsychotic drugs (i.e., a decrease in psychosis levels) parallels a decrease in plasma HVA levels in schizophrenic patients over time (Pickar et al. 1984(Pickar et al. , 1986Davidson and Davis 1988;Davila et al. 1988;Mazure et al. 1991;Sharma et al. 1989). Some studies have reported an initial increase in plasma HVA in the first week of antipsychotic drug From the VA Pittsburgh Healthcare System (MEK, JKY, DPvK), Pittsburgh, Pennsylvania; and Western Psychiatric Institute and Clinic (JKY, DPvK), University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania.Address correspondence to: Mary Kelley, MS, GIM (13OU), VA Pittsburgh H.S., University Drive C, Pittsburgh, PA 15240.Received March 27, 1998; revised July 24, 1998; accepted July 28, 1998. 604 M.E. Kelley et al. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 20 , NO . 6 treatment that also parallels the decrease in psychosis (Davila et al. 1988(Davila et al. , 1995Duncan et al. 1993), while others did not observe this effect (Pickar et al. 1986). Other studies of antipsychotic efficacy have focused on response status as the outcome measure and have shown that plasma HVA decreases were significant only in responders (Davidson et al. 1991a;Bowers et al. 1984;Chang et al. 1988;Van Putten et al. 1989). Some studies have shown that both plasma HVA and plasma MHPG decrease during neuroleptic treatment in those who respond favorably (Mazure et al. 1991;Bowers et al. 1984;Chang et al. 1990;Green et al. 1993).Higher pretreatment plasma HVA has been shown to predict better response (Mazure et al. 1991;Bowers et al. 1984Bowers et al. , 1986Chang et al. 1990;Duncan et al. 1993;Scheffer et al. 1994;van Kammen et al. 1996b), and faster time to r...

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Section: Blood Drawsmentioning

confidence: 94%

mentioning

confidence: 99%

Plasma Catecholamine Metabolites as Markers for Psychosis and Antipsychotic Response in Schizophrenia

Kelley

Yao

Kammen

1999

Neuropsychopharmacology

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“…Despite some argument (Kopin et al 1988;Lambert et al 1993;Maas et al 1988), several lines of investigations have focused on plasma levels of homovanillic acid (pHVA), a major metabolite of DA, for the study of DA-related mental disorders such as schizophrenia based on the assumption that dysfunction in central dopaminergic activity is, to some extent, reflected in this peripheral measure (see Friedhoff and Amin 1997 for review). While conflicting results have been reported regarding differences in pHVA levels between patients with schizophrenia and control subjects (Doran et al 1985;Koreen et al 1994;Maas et al 1993;Pickar et al 1984;Steinberg et al 1993;Sumiyoshi et al 1997a;Whelton et al 1993), there has been accumulated evidence for the association between pHVA levels in schizophrenia and the outcome of neuroleptic treatment (Akiyama et al 1995;Chang et al 1993;Davis et al 1985;Garver et al 1997;Green et al 1993;Nagaoka et al 1997;Sumiyoshi et al 1997b).…”

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confidence: 99%

Differential Effects of Mental Stress on Plasma Homovanillic Acid in Schizophrenia and Normal Controls

Sumiyoshi

Saitoh

Yotsutsuji

et al. 1999

Neuropsychopharmacology

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“…However, we recently ex amined the relationship of cerebrospinal fluid (CSF) homovanillic acid (HV A) to a complex component of schizophrenia (psychosis) and found a strong correla tion between the two (n = 24, r = 0.70, P = .00(1) (Maas et al unpublished observation). Several other groups have also found this strong correlation and have reported signiftcant correlations between plasma HV A and severity of psychosis (Davis et al 1991;Maas et al 1988;Pickar et al 1986). …”

Section: Although This Model In Which Psychopathologicmentioning

confidence: 73%

Psychopharmacology and the Etiology of Psychopathologic States: Are We Looking in the Right Way?

Katz

Maas

1994

Neuropsychopharmacol

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Dopamine Metabolism and Disposition in Schizophrenic Patients

Cited by 79 publications

References 44 publications

Plasma Catecholamine Metabolites as Markers for Psychosis and Antipsychotic Response in Schizophrenia

Plasma Catecholamine Metabolites as Markers for Psychosis and Antipsychotic Response in Schizophrenia

Differential Effects of Mental Stress on Plasma Homovanillic Acid in Schizophrenia and Normal Controls

Psychopharmacology and the Etiology of Psychopathologic States: Are We Looking in the Right Way?

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