Dopamine dynamics during emotional cognitive processing: Implications of the specific actions of clozapine compared with haloperidol

Kawano, Michitaka; Oshibuchi, Hidehiro; Kawano, Tetsuya; Muraoka, Hiroyuki; Tsutsumi, Tetsuyuki; Yamada, Makiko; Inada, Keiichi; Ishigooka, Jun

doi:10.1016/j.ejphar.2016.04.013

Cited by 15 publications

(7 citation statements)

References 38 publications

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“…The administration of neuroleptics as the dopamine receptor antagonists leads to modulation of diverse neuronal populations in the amygdala implicating several shared effects of these drugs. A recent report suggests that stabilized dopamine release in the amygdala is an important mechanism of haloperidol and clozapine actions during emotional processing (Kawano et al 2016 ). The D 1 family receptors (D 1 R) seems to play a crucial role the functioning of the amygdala and their activation in the basolateral nucleus (BLA) is necessary for the fear related responses (Li and Rainnie 2014 ; Macedo et al 2007 ) e.g.…”

Section: Introductionmentioning

confidence: 99%

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

et al. 2018

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Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.

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Section: Introductionmentioning

confidence: 99%

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

et al. 2018

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“…Subcortices and subnuclei were not reported. Heinsbroek et al, 1991;Inoue et al, 1994;Lane et al, 1982;Shekhar et al, 1994 Claustre et al, 1986;Deutch et al, 1985;George et al, 2001;Goldstein et al, 1994;Kamei et al, 1997;Lane et al, 1982;Morrow & Roth, 1995;Morrow et al, 1997;1999a;1999b;2004;Tsuchiya et al, 1996;Saphier & Welch, 1995;Swiergiel, 2003;Yoshishige et al, 1989 Coco et al, 1992;Heinsbroek et al, 1991;Inoue et al, 1994;Kamei et al, 1997;Tsuchiya et al, 1996 n.d. de Oliveira et al, 2011Feng et al, 2014;Kawano et al, 2016;Kitaichi et al, 2014;Miyagi et al, 2014;Muraoka et al, 2018;Oshibuchi et al, 2009;Suzuki et al, 2002;Yokoyama et al, 2005 Fulford & Marsden, 2007;Katoh et al, 1996;Kawade et al, 2022;Martinez et al, 2008;Matsumoto et al, 2005;Pezze et al, 2001;Wilkinson et al, 1998...…”

Section: Discussionmentioning

confidence: 99%

“…B Kawano et al, 2016;Muraoka et al, 2018;Pogorelov et al, 2012;Suzuki et al, 2002 (2-3 mg/kg, subchronic); Tsuchiya et al, 1996b (5-10 Shortall et al, 2013 (10 mg/kg, subacute) B Young et al, 2015 (7.8 mg/kg).…”

Section: Mdma Cocainementioning

confidence: 99%

50 Years of Research on Dopamine’s Role in Passive Aversive Conditioning and Extinction: A Systematic Review

Hamati

Ahrens

Holahan

et al. 2023

Preprint

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Dopamine, a catecholamine neurotransmitter, has historically been associated with the encoding of reward, whereas its role in aversion has received less attention. Here, we systematically gather the vast evidence for a role of dopamine in the simplest form of aversive learning: passive aversive conditioning and extinction. In the past, crude methods were used to augment or inhibit dopamine in order to study its relationship with fear conditioning and extinction. More advanced techniques such as conditional genetic, chemogenic, and optogenetic approaches now provide causal evidence for dopamine’s role in these learning processes. Dopamine neurons encode fear and extinction-related information and convey the signal via activation of D1, D2, D3, and D4 receptor sites particularly in the amygdala, prefrontal cortex, and striatum in order to continuously form, consolidate, retrieve, and update fear and extinction memory in a dynamic and reciprocal manner. Based on the reviewed literature, we conclude that dopamine is crucial for the encoding of passive aversive conditioning and contributes in a way that is comparable to its role in encoding reward.

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“…So far, the number of studies investigating differential effects of antipsychotic substances on brain regions involved in emotional processing is limited. Results from animal studies showed attenuation of amygdala activation under clozapine [54] and differential effects of aripiprazole and olanzapine on 5-HT1A serotonin receptor expression in the limbic system of the rat brain [55]. In humans, both quetiapine and risperidone have been described to increased BOLD-signal in brain regions involved in emotional processing [24].…”

Section: Discussionmentioning

confidence: 99%

Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine

Mier

Schirmbeck

Stoessel

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala–cortico–striatal network in the pathogenesis of obsessive–compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences.

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Dopamine dynamics during emotional cognitive processing: Implications of the specific actions of clozapine compared with haloperidol

Cited by 15 publications

References 38 publications

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

50 Years of Research on Dopamine’s Role in Passive Aversive Conditioning and Extinction: A Systematic Review

Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine

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