Dopamine constricts porcine pial veins

Sun, Man-Hua; Ishine, Takaaki; Lee, Tony Jer‐Fu

doi:10.1016/s0014-2999(97)01166-7

Cited by 7 publications

(2 citation statements)

References 24 publications

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“…Blood Vessels-D 2 receptor protein has been described in the heart and coronary artery (44). Dopamine at low and high concentrations constricts isolated porcine pial veins via postsynaptic α 2 -adrenoceptors and dopamine D 1 and D 2 receptors (228). However, in the cat and other species, D 1 receptors are vasodilatory; the D 2 receptor agonist LY-141865 is vasodilatory only at high concentrations (61).…”

Section: Localization Of the D 2 Receptor Subtypementioning

confidence: 99%

Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice

Zeng

Armando²,

Luo³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

124

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Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3), and D(4)) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.

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Section: Localization Of the D 2 Receptor Subtypementioning

confidence: 99%

Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice

Zeng

Armando²,

Luo³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

124

View full text Add to dashboard Cite

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“…with alpha2 adrenoceptors and dopamine D1 and D2 receptors [5]. In vivo investigations have demonstrated cerebral vasodilatation subsequent to dopamine administration [6] or after microapplication or perivascular microinjection of dopamine to pial arteries or subarachnoid membrane [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Dopamine D1-D5 receptor protein immunohistochemistry in dog pial arteries

Amenta¹,

Avola

Bronzetti

et al. 2000

J Headache Pain

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IntroductionSeveral studies have suggested a role of dopamine in the pathophysiology of migraine [1]. Functional experiments have shown that dopamine is involved in the control of cerebral circulation. Dopamine after blockade of alpha-or beta-adrenoceptors induces relaxation of the smooth muscle of cerebral arteries. These effects are mimicked by dopamine receptor agonists and blocked by dopamine receptor antagonists [2][3][4]. On the other hand, dopamine induces vasodilatation of pial arteries through an interaction

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