Dopamine D1-D5 receptor protein immunohistochemistry in dog pial arteries

Abstract

IntroductionSeveral studies have suggested a role of dopamine in the pathophysiology of migraine [1]. Functional experiments have shown that dopamine is involved in the control of cerebral circulation. Dopamine after blockade of alpha-or beta-adrenoceptors induces relaxation of the smooth muscle of cerebral arteries. These effects are mimicked by dopamine receptor agonists and blocked by dopamine receptor antagonists [2][3][4]. On the other hand, dopamine induces vasodilatation of pial arteries through an interaction