Dopamine and noradrenaline levels in the brains of lead and zinc poisoned rats

Satija, Narinder K.; Seth, T. D.; Tandon, Deepak S.

doi:10.1016/0300-483x(78)90050-1

Cited by 17 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, increased DA levels are seen in the akinetic mutants in Catsup , the fly homolog of zinc transporter ZIP7 [40], which physically interacts with TH and GTPCH [99, 120]. The role of mammalian ZIP7 in DA synthesis has not been investigated, but increased zinc uptake has been associated with decreased levels of TH [97] and DA [89] in rats.…”

Section: Genes and Drugs Involved In Dopamine Dynamics And Signaling mentioning

confidence: 99%

Dopamine Dynamics and Signaling in <i>Drosophila</i>: An Overview of Genes, Drugs and Behavioral Paradigms

2014

View full text Add to dashboard Cite

Changes in dopamine (DA) signaling have been implicated in a number of human neurologic and psychiatric disorders. Similarly, defects in DA signaling in the fruit fly, Drosophila melanogaster, have also been associated with several behavioral defects. As most genes involved in DA synthesis, transport, secretion, and signaling are conserved between species, Drosophila is a powerful genetic model organism to study the regulation of DA signaling in vivo. In this review, we will provide an overview of the genes and drugs that regulate DA biology in Drosophila. Furthermore, we will discuss the behavioral paradigms that are regulated by DA signaling in flies. By analyzing the genes and neuronal circuits that govern such behaviors using sophisticated genetic, pharmacologic, electrophysiologic, and imaging approaches in Drosophila, we will likely gain a better understanding about how this neuromodulator regulates motor tasks and cognition in humans.

show abstract

Section: Genes and Drugs Involved In Dopamine Dynamics And Signaling mentioning

confidence: 99%

Dopamine Dynamics and Signaling in <i>Drosophila</i>: An Overview of Genes, Drugs and Behavioral Paradigms

2014

View full text Add to dashboard Cite

show abstract

“…A 3-day i.p. administration of 5 mg zinc acetate/kg body weight resulted in a significant increase in NE levels in the whole brains of rats, whereas DA levels slightly decreased [99]. Wallwork et al [100] observed that the NE level increased in the brains of rats fed a zinc-deficient diet for 9-10 days compared with pair-fed or ad libitum-fed control rats, which received the same diet as the zinc-deficient group but were given zinc acetate via their drinking water.…”

Section: Norepinephrine (Ne)mentioning

confidence: 99%

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

et al. 2017

View full text Add to dashboard Cite

Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.

show abstract

“…1975)and in vivo (Haeger-Aronsen & Schutz 1976). O n the other hand, rat whole brain noradrenaline has been reported to increase similarly after giving Pb o r Zn alone or in combination intraperitoneally t o rats (Satija et al 1978), and Zn could not reverse the Pb-induced decrease of the motor conduction velocity in rabbits (Hietanen et al 1982).…”

mentioning

confidence: 97%

“…There is evidence that P b interferes also with zinc (Zn) and copper (Cu) (Petering 1980). O n the other hand, rat whole brain noradrenaline has been reported to increase similarly after giving Pb o r Zn alone or in combination intraperitoneally t o rats (Satija et al 1978), and Zn could not reverse the Pb-induced decrease of the motor conduction velocity in rabbits (Hietanen et al 1982). Their simultaneous exposure makes the interaction of Pb and Z n significant.…”

mentioning

confidence: 99%

Enhancement of 5‐Hydroxytryptamine Uptake in Rabbit Hypothalamic Synaptosomes but not in Blood Platelets by Zinc and Lead ex Vivo

Komulainen

1983

Acta Pharmacologica et Toxicologica

View full text Add to dashboard Cite

Lead (0.2%), zinc (0.5%) or their combination was given to rabbits as acetate salts in drinking water for 2 or 4 weeks. Cerebral Pb increased within exposure time but the increase of Zn was marginal when given alone. After combination of P b S Zn, blood Pb increased but Zn decreased as compared to the administration of the single metal alone. Concurrently brain Pb increased but remained at a lower level as compared with solePb administration while brain Zn did not differ from controls. The uptake of 5-hydroxytryptamine (5-HT) into hypothalamic synaptosomes increased 70-85% with Pb, Zn and PbSZn after 2 weeks and 93% with Zn and 76% with Pb+Zn after 4 weeks. Dopamine uptake into striatal synaptosomes did not change. Zn decreased . endogenous noradrenaline concentrations by 21 % and Pb+Zn that of 5-HT by 36% in the striatum. P b f Zn decreased cortical dopamine concentrations by 26%. Concurrently, 5-HT uptake in blood platelets, platelet numbers and their content of endogenous 5-HT did not change significantly. These results indicate that high Zn and Pb have parallel effects on 5-HT uptake in hypothalamic synaptosomes and their combination may be neurochemically more toxic than the individual metals. The increase of 5-HT uptake in hypothalamic synaptosomes but not in blood platelets requires further methodological work to explain the differences between synaptosomes and platelets.

show abstract

Dopamine and noradrenaline levels in the brains of lead and zinc poisoned rats

Cited by 17 publications

References 18 publications

Dopamine Dynamics and Signaling in <i>Drosophila</i>: An Overview of Genes, Drugs and Behavioral Paradigms

Dopamine Dynamics and Signaling in <i>Drosophila</i>: An Overview of Genes, Drugs and Behavioral Paradigms

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

Enhancement of 5‐Hydroxytryptamine Uptake in Rabbit Hypothalamic Synaptosomes but not in Blood Platelets by Zinc and Lead ex Vivo

Contact Info

Product

Resources

About