Donor Selection in Allogeneic Stem Cell Transplantation

Brucellosis in Immunocompromised Hosts

“…Transmission of bacteria to a recipient of HSCT usually occurs through: (1) contamination of the graft, (2) blood of the donor, (3) bone marrow of the donor, and (4) blood product transfusions in the post-HSCT period [29,57,100,105,[116][117][118][126][127][128]. The reported contamination rates of about 1 per 3000 units as observed in blood products seem to be excessive in the absence of definitive information and data from other studies [116].…”

“…The potentially transmittable diseases from HSCT donors include: (1) infections caused by various micro-organisms as shown in Table 1, [104,105,113,[115][116][117], (2) congenital diseases such as thalassemia, (3) autoimmune disorders such as autoimmune thrombocytopenia, and (4) malignancies such as leukemia and lymphoma [116]. Donor-derived infections caused by viruses, fungi, parasites, Mycobacteriae and several other bacteriae including Brucella species have been reported in recipients of HSCT [104,105,113,[115][116][117][126][127][128]. One of the prerequisites for donating hematopoietic stem cells is to have a healthy donor who will pass all screening tests for various infections [128].…”

“…Donor-derived infections caused by viruses, fungi, parasites, Mycobacteriae and several other bacteriae including Brucella species have been reported in recipients of HSCT [104,105,113,[115][116][117][126][127][128]. One of the prerequisites for donating hematopoietic stem cells is to have a healthy donor who will pass all screening tests for various infections [128]. Once a certain infection is diagnosed in a potential donor for HSCT, it has to be treated appropriately before reconsidering the donor again [128].…”

“…One of the prerequisites for donating hematopoietic stem cells is to have a healthy donor who will pass all screening tests for various infections [128]. Once a certain infection is diagnosed in a potential donor for HSCT, it has to be treated appropriately before reconsidering the donor again [128]. Identification of donors at high risk of transmittable infections is essential and HSCT donors should have thorough evaluation and detailed history [116].…”

“…Brucella serology is usually performed during the period of donor evaluation within at least 30 days prior to stem cell donation [127]. Brucellosis in a donor of HSCT should be treated and the donor should not be allowed to donate stem cells till at least two years after full recovery from the infection [128]. Brucella infections have been: (1) transmitted to recipients of HSCT through allografts harboring Brucella species, and (2) reported in recipients of HSCT after achieving successful engraftment [29,57,100,105,[116][117][118].…”