Donor safety issues in high‐dose platelet collection using the latest apheresis systems

Chaudhary, Rajendra; Das, Sudipta Sekhar; Khetan, Dheeraj; Ojha, Shashank; Verma, Sunil Kumar

doi:10.1111/j.1778-428x.2009.01116.x

Cited by 11 publications

(15 citation statements)

References 21 publications

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“…The platelet yield in our study (6.14 ± 0.26 9 10 11 ) was comparable to that of Fontana et al [25] and Keklik et al [26] but was lower when compared to the study by Jaipian et al [24] .The reason behind this could be attributed to the higher mean pre-procedure platelet count (339 9 10 3 /lL vs. 308 9 10 3 /lL) and higher target yield (6.5 9 10 11 ) in the study by Jaipian et al as compared to ours. Our DDP yield was higher than that obtained by Chaudhary et al [23] (5.4 ± 0.6 9 10 11 ) as their target yield was lower than our study (5.5 9 10 11 vs. 6 9 10 11 ). The donor comfort is vital during the DDP collection which is mainly related to the time taken for the procedure to complete.…”

Section: Discussioncontrasting

confidence: 90%

“…Glicher and Smith [22] found that DDP can be obtained when the donor platelet count is C 250 9 10 3 /lL. Chaudhary et al [23] and Jaipian et al [24] also considered the pre-procedure platelet count of C 250 9 10 3 /lL for DDP collection. Accordingly, we considered only those donors for DDP whose pre-donation platelet count was C 250 9 10 3 /lL.…”

Section: Discussionmentioning

confidence: 99%

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Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management

Makroo

Fadadu

Agrawal

et al. 2018

Indian J Hematol Blood Transfus

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The double dose plateletpheresis (DDP) is considered to be a cost effective way of preparing platelets, owing to the low incidence of infectious complications and by also minimizing allogeneic donor exposure to the patients. We aimed at collecting DDP at our center and study its effect on donor hematological parameters, evaluate the product quality and the adverse donor reactions thereafter. Double Dose Platelet was collected from 160 eligible apheresis donors on Amicus cell separator (Fenwal, Inc. Three Corporate Drive Lake Zurich, IL, USA). The donor hematological parameters, product yield, adverse effects on the donors, collection efficiency (CE) and collection rate of the machine were noted. A total of 160 DDPs were collected. The total blood volume processed to achieve the yield of 6.0 9 1011 was 3673.5 ± 276.56 mL. The average yield achieved was 6.14 ± 0.26 9 1011. The average run time was 68.05 ± 6.25 min. Total ACD used was 408.33 ± 33.81 mL. We observed significant relation of pre-donation donor platelet count and platelet yield (p \ 0.001). The CE was 78.09 ± 5.15%. There was a significant drop in the post DDP platelet count (p \ 0.01) causing no adverse effect. Fourteen donors (8.75%) experienced mild citrate related adverse events. DDP does not lead to major adverse effects and post DDP hematological parameters are also within the acceptable range. It also helps to maintain apheresis platelet inventory, reduce donor exposure, reduce donor requirement and reduce the cost of the product.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management

Makroo

Fadadu

Agrawal

et al. 2018

Indian J Hematol Blood Transfus

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“…Developments in medical sciences, including organ transplantat ion pro grams, has significant ly increased the demand for platelets. 12 Collection of platelets by apheresis has been a major advance in transfusion medicine and it is advantageous over random donor platelets. Such SDPs allow supply of a therapeutically beneficial component ensuring leucocyte reduction of less than 5  10 6 /unit thereby decreasing febrile non-haemolytic transfusion reactions, limited donor exposure thereby reduced infectious complications and supply of HLA matched platelet concentrates in refractory patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in pre- and post-donation haematological parameters in plateletpheresis donors

et al. 2014

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Background:Recently the use of single donor platelet (SDP) concentrates has grown steadily due to its employment in chemotherapy protocols. Technical advances in automated cell separators have substantially improved the productivity and quality of the collection of apheresis platelets. Methods: We prospectively studied 90 healthy donors who volunteered for plateletpheresis. We compared the preand post-plateletpheresis haematological values, namely, haemoglobin (Hb), haematocrit, platelet count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelet distribution width (PDW), red blood cell count, white blood cell (WBC) count and mean platelet volume (MPV) in all of them. Results: Following plateletpheresis a significant decrease in pre-and post-donation Hb (g/dL) (14.8 ± 1.097 Vs 14.5 ± 1.4; p=0.002); haematocrit (%) (43.29 ± 6.62 Vs 41.64 ± 4.96; p=0.045); platelet count ( 10 9 /L) (280.34 ± 54.55 Vs 175.58 ± 44.56; p< 0.001); WBC count ( 10 3 /μL) (8.28 ± 1.88 Vs 6.95 ± 1.76; p< 0.001); and PDW (fL) (15.96 ± 1.38 Vs 4.96 ± 0.67; p=0.053) and a slight rise in MPV (fL) (8.61 ± 0.77 Vs 8.72 ± 0.83; p=0.067) were observed. However, none of them developed clinical manifestation of anaemia or thrombocytopenia. Conclusions: Close monitoring and follow-up for these donors is indicated to prevent unfavourable events caused by these changes. DS. Changes in pre-and post-donation haematological parameters in plateletpheresis donors. J Clin Sci Res 2014;3:85-9. DOI: http://dx.

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“…Safety concerns of apheresis are circulatory side‐effects [23,24], anticoagulant induced adverse events [23,24], donors’ post‐apheresis blood count [23] and a possible impact on haematopoiesis [25]. In general, apheresis procedures have a higher incidence of adverse events compared with manual whole blood donation.…”

Section: Side‐effects Of Multicomponent Donationmentioning

confidence: 99%

Feasibility and safety of multicomponent apheresis donation

Moog

2011

ISBT Science Series

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Background and Objectives Modern apheresis devices offer the possibility to collect blood components that are well standardized, as compared with those available with manual whole blood donations. Recent technologic advances in multicomponent donation have made possible the development of systems that can collect different blood components from the same donor during one apheresis session. Red blood cells (RBCs) can be concurrently collected with plasma or platelets (PLTs).Materials and Methods A PLT yield of ‡2 · 10 11 per unit according to European guidelines can be targeted by the algorithm of the blood cell separators after entering donor specific parameters such as body weight, height and blood counts. Furthermore, two units of RBCs can also be collected during one apheresis session provided that the donor fulfils the eligibility criteria for that procedure.Results The haemoglobin content of apheresed RBCs after addition of additive solution is higher than the minimal European requirement of whole blood derived RBCs of 40 g per unit due to standardization. Automated blood cell separators permit predictable collection of blood components with consistent yields and volumes. Repeat apheresis donors accept multicomponent donation and consent to concurrent component collection in >90% of the procedures. The results of a national survey showed that approximately 75% were willing to give an additional RBC unit four times per year. This allows blood centres to increase the number of units colleted at low extra costs. Collecting an additional RBC unit in plateletpheresis causes extra costs of approximately 20€ for disposables and work load compensating the production costs with respect to the selling price. The incidence of acute adverse events in multicomponent apheresis was reported with less than 1%. Small, female donors with lower pre-donation haematocrit were at higher risk for adverse events, especially when RBCs were collected. Double unit RBC collection showed to be safe if special eligibility criteria were respected.Conclusion Previous definitions of blood component yield and volume as well as the flexibility to collect those multicomponents allow the blood centre to collect those components that maximize donors' contribution and to meet the demands of its area hospitals for blood components. Blood transfusion services are progressively increasing their reliance on apheresis technology to optimize the number of blood components collected per donor visit and to reduce the number of donors a patient is exposed to. The use of these systems has shown at the same time that multicomponent donations have been well tolerated by the donors and are cost-effective.

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Donor safety issues in high‐dose platelet collection using the latest apheresis systems

Cited by 11 publications

References 21 publications

Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management

Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management

Changes in pre- and post-donation haematological parameters in plateletpheresis donors

Feasibility and safety of multicomponent apheresis donation

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